Results 271 to 280 of about 362,273 (289)

Linkage of reduction in 1-phosphatidylinositol 4-kinase activity and inositol 1,4,5-trisphosphate concentration in human ovarian carcinoma cells treated with quercetin

Life Sciences, 1995
Quercetin inhibited 1-phosphatidylinositol (Pl) 4-kinase, EC 2.7.1.67 (Pl kinase) activity in a concentration-dependent manner (IC50 = 4 microM) in particulate extracts from human ovarian carcinoma. In OVCAR-5 cells quercetin produced growth inhibition (IC50 = 63 microM) and cytotoxicity (LC50 = 17 microM).
N, Prajda, R L, Singhal, Y A, Yeh, E, Olah, K Y, Look, G, Weber   +5 more
openaire   +3 more sources

1-Phosphatidylinositol 4-kinase

1997
Dietmar Schomburg, Dörte Stephan
openaire   +2 more sources

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria.

Journal of Medicinal Chemistry, 2018
A novel 2,8-disubstituted-1,5-naphthyridine hit compound stemming from the open access Medicines for Malaria Venture Pathogen Box formed a basis for a hit-to-lead medicinal chemistry program.
Nishanth Kandepedu, Diego González Cabrera, Srinivas Eedubilli, Dale Taylor, Christel Brunschwig, Liezl Gibhard, Mathew Njoroge, N. Lawrence, Tanya Paquet, C. Eyermann, T. Spangenberg, G. Basarab, L. Street, K. Chibale   +13 more
semanticscholar   +1 more source

1-Phosphatidylinositol 4-kinase: an enzyme linked with proliferation and malignancy.

Cancer research, 1994
The activity of 1-phosphatidylinositol 4-kinase (EC 2.7.1.67), the first committed ATP-utilizing enzyme of inositol 1,4,5-trisphosphate and diacylglycerol biosynthesis, was determined in a spectrum of rat hepatomas of different growth rates, in sarcoma, and in normal tissues of high cell renewal rates which include differentiating and regenerating ...
M T, Rizzo, G, Weber
openaire   +1 more source

Annexin 2 is a phosphatidylinositol (4,5)-bisphosphate binding protein recruited to actin assembly sites at cellular membranes

Journal of Cell Science, 2004
U. Rescher, D. Ruhe, Carsten Ludwig, N. Zobiack, V. Gerke   +4 more
semanticscholar   +1 more source

Quercetin down-regulates signal transduction in human breast carcinoma cells.

Biochemical and Biophysical Research Communications - BBRC, 1995
R. L. Singhal, Y. Yeh, N. Prajda, Edith Olah, G. Sledge, George Weber   +5 more
semanticscholar   +1 more source