Results 271 to 280 of about 317,690 (321)

Evans Blue Acts as a Selective Inhibitor of CaMKII‐α to Impede the Progression of TCL Identified by HTS

Cancer Science, EarlyView.
ABSTRACT T‐cell lymphoma (TCL) poses a significant challenge in clinical oncology, characterized by its aggressive behavior and resistance to conventional therapies. Despite considerable research efforts, the prognosis for TCL patients remains poor, primarily due to the lack of effective therapeutic strategies that can inhibit tumor progression and ...
Jianru Tian, Aiqin Zhang, Lansong Li, Hong Liu, Hui Jiang, Ruqi Liang   +5 more
wiley   +1 more source

Inhibition of Rho-kinase by fasudil contributes to the modulation of the synaptic plasticity response in the rat hippocampus. [PDF]

Pflugers Arch
Babur E, Saray H, Süer C, Dursun N.
europepmc   +1 more source

Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules

Cell Proliferation, EarlyView.
A potent combination of small molecules YFSS (Y27632, Forskolin, SB431542, SP600125) that were screened through a neuronal‐specific promoter–reporter system TUBB3::mCherry effectively induces neuronal‐GBM conversion in vitro and in vivo, unveiling molecular mechanisms that offer a theoretical basis and a potential therapeutic strategy for treating GBM.
Ya'nan Hu, Jinming Liu, Jian Tu, Min Yang, Qisheng He, Fei Li, Xiaojing Xu, Zhongqing Ji, Jianwei Xu, Wentao Zhong, Mengwen Yan, Ying Yang, Huanxiang Zhang   +12 more
wiley   +1 more source

Nobiletin alleviates brain injury in uremic mice and inhibits indoxyl sulfate-induced neurotoxicity in HT22 cells through the phosphatidylinositol 3-kinase/protein kinase B signaling pathway.

Cytojournal
Xu L, Zhang R.
europepmc   +1 more source

EFR3A, an Intriguing Gene, and Protein with a Scaffolding Function. [PDF]

Cells
Trybus M, Hryniewicz-Jankowska A, Czogalla A, Sikorski AF.   +3 more
europepmc   +1 more source

Scalable Matrigel‐Free Suspension Culture for Generating High‐Quality Human Liver Ductal Organoids

Cell Proliferation, EarlyView.
A novel matrigel‐free suspension culture enhances the generation of high‐quality human liver ductal organoids, which shows remarkable efficacy in mice transplantation. ABSTRACT Liver transplantation is currently the sole definitive treatment option for end‐stage liver failure.
Senyi Gong, Kangxin He, Yu Liu, Xingyu Luo, Kamran Ashraf, Jinzhao He, Weifeng Li, Lihua Yang, Touseef Ur Rehman, Mingwei Shen, Qinbiao Yan, Ali Mohsin, Shusen Zheng, Zhe Yang, Meijin Guo   +14 more
wiley   +1 more source

Prominin 2 knockdown inhibits the growth, migration, and invasion of non-small cell lung cancer cells by repressing phosphatidylinositol 3 kinase/protein kinase B pathway.

Cytojournal
He B, Chen Z, Zhong L, Pang X.
europepmc   +1 more source

Capivasertib plus fulvestrant in patients with HR-positive/HER2-negative advanced breast cancer: phase 3 CAPItello-291 study extended Chinese cohort. [PDF]

Nat Commun
Hu X, Zhang Q, Sun T, Xiong H, Li W, Teng Y, Lu YS, Tseng LM, Yan M, Li H, Pang D, -Chen SC, Chen W, Jiang O, Wang J, Wu X, Wang X, Zang A, Wang X, Collins JM, Fan E, Jiang L, Zeng X, Turner NC.   +23 more
europepmc   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

<i>AKT1</i> and <i>CTNNB1</i> mutations as drivers of paclitaxel resistance in breast cancer cells. [PDF]

Oncol Lett
Altiparmak-Ulbegi G, Hasbal-Celikok G, Aksoy-Sagirli P.   +2 more
europepmc   +1 more source