10-hydroxy-2-decenoic acid - Open Access .click

Metabolic Engineering
10-hydroxy-2-decenoic acid (10-HDA), a unique unsaturated fatty acid present in royal jelly, has attracted considerable interest due to its potential medical applications. However, its low concentration in royal jelly and complex conformational structure present challenges for large-scale production. In this study, we designed and constructed a de novo
Jesus F Barajas, Junfeng Shen
exaly +3 more sources

Biosynthesis of 10-Hydroxy-2-decenoic Acid through a One-Step Whole-Cell Catalysis

Journal of Agricultural and Food Chemistry
10-Hydroxy-2-decenoic acid (10-HDA) is an important component of royal jelly, known for its antimicrobial, anti-inflammatory, blood pressure-lowering, and antiradiation effects. Currently, 10-HDA biosynthesis is limited by the substrate selectivity of acyl-coenzyme A dehydrogenase, which restricts the technique to a two-step process.
Junqing Wang
exaly +3 more sources

10-Hydroxy-2-decenoic acid from Royal jelly: A potential medicine for RA

Journal of Ethnopharmacology, 2010
Rheumatoid arthritis synovial fibroblasts (RASFs) are known to produce matrix metalloproteinases (MMPs) and cause joint destruction. The purpose of this study is to develop a potential medicine for rheumatoid arthritis (RA).To this end, first, the MMPs inhibition factor was purified from an alkali-solubilized fraction of RJ (Apis mellifera) by C18 ...
Xin-Yu, Yang +10 more
exaly +3 more sources

royal jelly
bee pollen
molecular docking

10-hda
autophagy
apoptosis

propolis
honey
fatty acids