Results 81 to 90 of about 26,640,125 (414)

Small molecule splicing modifiers with systemic HTT-lowering activity

Nature Communications, 2021
Here the authors describe the discovery of a class of small molecule splicing modifiers which are orally bioavailable, cross the blood-brain barrier, and lower levels of huntingtin in a mouse model of Huntington’s disease (HD).
Anuradha Bhattacharyya, Christopher R. Trotta, Jana Narasimhan, Kari J. Wiedinger, Wencheng Li, Kerstin A. Effenberger, Matthew G. Woll, Minakshi B. Jani, Nicole Risher, Shirley Yeh, Yaofeng Cheng, Nadiya Sydorenko, Young-Choon Moon, Gary M. Karp, Marla Weetall, Amal Dakka, Vijayalakshmi Gabbeta, Nikolai A. Naryshkin, Jason D. Graci, Thomas Tripodi, Amber Southwell, Michael Hayden, Joseph M. Colacino, Stuart W. Peltz   +23 more
doaj   +1 more source

A 100-Year Review: Mastitis detection, management, and prevention.

Journal of Dairy Science, 2017
Mastitis is the most frequent disease of dairy cows and has well-recognized detrimental effects on animal wellbeing and dairy farm profitability. Since the beginning of modern dairy farming, producers have sought effective methods to minimize the ...
P. Ruegg
semanticscholar   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Chemosensing in microorganisms to practical biosensors

, 2012
Microorganisms like bacteria can sense concentration of chemo-attractants in its medium very accurately. They achieve this through interaction between the receptors on their cell surface and the chemo-attractant molecules (like sugar).
Ghosh, Surya K., Kundu, Tapanendu, Sain, Anirban   +2 more
core   +2 more sources

An overview of ordered adlayer structures for CO and NO on the (100) surface of Pt, Rh, Ni, Cu and Pd [PDF]

arXiv, 2009
Many ordered adlayer structures have been reported for CO on the (100) surfaces of Pt, Rh, Pd, Ni and Cu. Also, some ordered structures are known for NO on the same surfaces. The current review includes all those articles that give a graphical representation of the position of the adsorbates inside the unit cell. The emphasis is on the case of CO on Pt(
arxiv  

Highly Luminescent Phase-Stable CsPbI3 Perovskite Quantum Dots Achieving Near 100% Absolute Photoluminescence Quantum Yield.

ACS Nano, 2017
Perovskite quantum dots (QDs) as a new type of colloidal nanocrystals have gained significant attention for both fundamental research and commercial applications owing to their appealing optoelectronic properties and excellent chemical processability ...
Feng Liu, Yaohong Zhang, Chao Ding, Syuusuke Kobayashi, Takuya Izuishi, Naoki Nakazawa, T. Toyoda, T. Ohta, S. Hayase, T. Minemoto, K. Yoshino, Songyuan Dai, Q. Shen   +12 more
semanticscholar   +1 more source

Engineering cryogenic setups for 100-qubit scale superconducting circuit systems [PDF]

EPJ Quantum Technology, 2018
A robust cryogenic infrastructure in form of a wired, thermally optimized dilution refrigerator is essential for solid-state based quantum processors. Here, we engineer a cryogenic setup, which minimizes passive and active heat loads, while guaranteeing ...
S. Krinner, S. Storz, P. Kurpiers, P. Magnard, J. Heinsoo, R. Keller, Janis Luetolf, C. Eichler, A. Wallraff   +8 more
semanticscholar   +1 more source

Residues R177 and S178 of the human Na+/H+ antiporter NHA2 are involved in its inhibition by the flavonoid phloretin

FEBS Letters, Volume 599, Issue 6, Page 901-911, March 2025.
The human Na+/H+ antiporter NHA2 transports Na+ or Li+ in exchange for protons across cell membranes, and its dysfunction results in various pathologies, e.g., fertility disorders, hypertension, or diabetes. This work provides the molecular characterization of interactions of NHA2 with its specific inhibitor phloretin, which can be helpful for the ...
Olga Zimmermannova, Martin Kubeš, Tereza Przeczková, Gal Masrati   +3 more
wiley   +1 more source

Synthesis of Self-assembled Iron Silicon Oxide Nanowires onto Single-crystalline Si(100) [PDF]

arXiv, 2013
Iron silicon oxide nanowire has been synthesized by putting single crystalline Si(100) wafer into ammonium iron sulfate, hydrogen peroxide, and triethylamine solution heated to from 70 to 100 degree in the air. The prepared iron silicon oxide nanowires with diameters of about 10nm (onto non etched Si(100) wafer) and about 75nm(onto etched Si(100) wafer)
arxiv  

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source