Results 111 to 120 of about 618 (145)

Isomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid reduce renin activity and increase water and electrolyte excretion.

The Journal of Pharmacology and Experimental Therapeutics, 1990
A metabolite of arachidonic acid, 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE), which can be formed either in the 12-S or 12-R configuration, has a diversity of biological actions and is generated by a number of tissues including the renal glomerulus and the vasculature.
C P, Quilley, J C, McGiff
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Cutaneous responses to 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) and 5,12-dihydroxyeicosatetraenoic acid (leukotriene B4) in psoriasis and normal human skin

Archives of Dermatological Research, 1987
The arachidonate lipoxygenase products 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) and 5(S),12(R)-dihydroxy-6,8,10,14-eicosatetraenoic acid (leukotriene B4, LTB4) are potent leucocyte chemoattractants in vitro and in vivo. Both 12-HETE and LTB4-like material are found in increased amounts in lesional skin in psoriasis.
P M, Dowd, A K, Black, P W, Woollard, M W, Greaves   +3 more
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Effects of oxo and dihydro metabolites of 12-hydroxy-5,8,10,14-eicosatetraenoic acid on chemotaxis and cytosolic calcium levels in human neutrophils

Journal of Leukocyte Biology, 1995
Abstract One of the pathways of metabolism of leukotriene B4 (LTB4) and 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) in leukocytes is oxidation of the 12-hydroxyl group, followed by reduction of the 10,11-double bond. In the case of 12R-HETE and 12S-HETE, this results in the formation of 12-oxo-ETE, 10,11-dihydro-12-oxo-ETE, and ...
W S, Powell, M, Hashefi, J R, Falck, K, Chauhan, J, Rokach, S S, Wang, E, Mills, R J, MacLeod   +7 more
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Selective stimulation of human platelet lipoxygenase product 12-hydroxy-5,8,10,14-eicosatetraenoic acid by chlorpromazine and 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982
Stimulation of human platelets by thrombin and by the Ca2+ ionophore A23187 leads to a rapid Ca2+-dependent activation of phospholipases that release membrane-bound arachidonic acid for oxidation by a cyclooxygenase and lipoxygenase enzymes into so-called eicosanoids.
J, Maclouf, H, De la Baume, S, Levy-Toledano, J P, Caen   +3 more
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Stereochemical difference between 12-hydroxy-5,8,10,14-eicosatetraenoic acid in platelets and psoriatic lesions

Biochemical and Biophysical Research Communications, 1986
Stereochemical analysis of 12-hydroxy-5,8,10,14-eicosatetraenoic acid derived from the lesional scale of patients with psoriasis is reported. Resolution of the C-12 hydroxyl enantiomers was carried out by high pressure liquid chromatography of their diastereomeric methyl ester dehydroabietyl urethane derivatives.
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The effect of adrenalectomy on the aggregation of rat blood platelets and the endogenous formation of thromboxane B2 and 12-hydroxy-5,8,10,14-eicosatetraenoic acid

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1988
Rat platelets were isolated and labelled with [1-14C] arachidonic acid. After aggregation thromboxane B2, 12-hydroxy 5,8,10-heptadecatrienoic acid (HHT) and 12-hydroxy-eicosatetraenoic acid (12-HETE) were the main metabolites formed. A comparison was made between several properties of the platelets of adrenalectomized and sham operated rats.
J E, Vincent, F J, Zijlstra
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Quantitative stereochemical analysis of subnanogram amounts of 12-hydroxy-(5,8,10,14)-eicosatetraenoic acid by sequential chiral phase liquid chromatography and stable isotope dilution mass spectrometry

Analytical Biochemistry, 1988
The two enantiomers of 12-hydroxy-(5,8,10,14)-eicosatetraenoic acid (12-HETE) are products of different biosynthetic pathways and have distinct biologic actions. Conventional methods of stereochemical analysis of 12-HETE require multimicrogram amounts of material and cannot be applied to systems where the availability of tissue is limited and only ...
J, Turk, W T, Stump, B A, Wolf, R A, Easom, M L, McDaniel   +4 more
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Rapid method for automated on-line extraction and fractionation of plasma leukotrienes and 12-hydroxy-5,8,10,14-eicosatetraenoic acids by reversed-phase high-performance liquid chromatography

Journal of Chromatography B: Biomedical Sciences and Applications, 1992
A method is described for automated on-line extraction and fractionation of plasma leukotrienes (LTs) and (5Z,8Z,10E,14Z)-(12S)-hydroxy-5,8,10,14-eicosate traenoic acid [12(S)-HETE] by reversed-phase high-performance liquid chromatography (RP-HPLC).
E L, VanAlstyne, S M, Spaethe
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Arachidonic acid metabolism in isolated pancreatic islets. V. The enantiomeric composition of 12-hydroxy-5,8,10,14-eicosatetraenoic acid indicates synthesis by a 12-lipoxygenase rather than a monooxygenase

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1989
Recent evidence indicates that the arachidonate metabolite 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) or its precursor may act as a second messenger in stimulus-response coupling in a variety of cells including Aplysia neurons, adrenal glomerulosa cells, and pancreatic islets.
J, Turk, B A, Wolf, R A, Easom, J H, Hughes, M L, McDaniel   +4 more
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Age-related increase in the migration of aortic smooth muscle cells induced by 12--hydroxy-5,8,10,14-eicosatetraenoic acid

Atherosclerosis, 1984
Studies were made on how age influenced the migration of aortic smooth muscle cells. For this, aortic cells from rats of various ages were established in culture in vitro and migration of the cells was measured by the filter membrane technique in modified Boyden chambers.
J, Nakao, H, Ito, Y, Koshihara, S, Murota   +3 more
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