Results 121 to 130 of about 618 (145)

The Stereochemical Analysis of Monohydroxyfatty Acids, Particularly 12-Hydroxy-5,8,10,14-Eicosatetraenoic Acid

1988
Monohydroxy acids are major lipoxygenase-like metabolites in extracts from the skin of psoriatic patients. An interest in the origin and therefore mechanism of formation of these compounds stimulated investigation of their stereochemistry. Chiral methods using HPLC have been developed for separation and quantification of the hydroxyl enantiomers as ...
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Increased activity and stimulability of psoriatic epidermal soluble guanylate cyclase by arachidonic acid and 12-hydroxy-5,8,10,14-eicosatetraenoic acid.

Advances in cyclic nucleotide research, 1980
Soluble guanylate cyclase activity was measured in normal and psoriatic human epidermis. The specific activity of guanylate cyclase was determined to be increased 10-fold and 3-fold in involved and uninvolved epidermis of psoriatics, respectively, compared with normal epidermis.
J S, Cantieri, G, Graff, N D, Goldberg
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Metabolism of Leukotriene B₄ (LTB₄) and 12‐Hydroxy‐5,8,10,14‐Eicosatetraenoic Acid (12‐HETE) in Human Keratinocytes^a

Annals of the New York Academy of Sciences, 1994
P, Wheelan, J B, Travers, J G, Morelli, R C, Murphy   +3 more
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Identification and measurement of 12-hydroxy-5,8,10,14-eicosatetraenoic acid in whole blood: implications for the radioimmunoassay of leukotriene B4

Biochemical Society Transactions, 1987
F. CAREY, R. A. FORDER, D. HAWORTH, P. M. WOOLLARD   +3 more
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Tumour fatty acid metabolism in the context of therapy resistance and obesity

Nature Reviews Cancer, 2021
Andrew J Hoy, Shilpa R Nagarajan, Lisa M Butler   +2 more
exaly  

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

Cancer Cell, 2022
Kota Itahashi, Yosuke Togashi, Takahiro Kamada   +2 more
exaly  

Mechanisms of retinoic acid signalling and its roles in organ and limb development

Nature Reviews Molecular Cell Biology, 2015
Thomas J Cunningham, Gregg Duester
exaly  

Pharmacological modulation of nucleic acid sensors — therapeutic potential and persisting obstacles

Nature Reviews Drug Discovery, 2019
Claire Vanpouille-Box, Lorenzo Galluzzi
exaly  

Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria

Nature Reviews Microbiology, 2008
Jerry M Wells, Annick Mercenier
exaly  

Targeting bile-acid signalling for metabolic diseases

Nature Reviews Drug Discovery, 2008
Charles Thomas, Johan Auwerx, Kristina Schoonjans   +2 more
exaly