Results 71 to 80 of about 402 (97)

Isomers of 12-hydroxy-5,8,10,14-eicosatetraenoic acid reduce renin activity and increase water and electrolyte excretion.

The Journal of Pharmacology and Experimental Therapeutics, 1990
A metabolite of arachidonic acid, 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE), which can be formed either in the 12-S or 12-R configuration, has a diversity of biological actions and is generated by a number of tissues including the renal glomerulus and the vasculature.
C P, Quilley, J C, McGiff
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The effect of adrenalectomy on the aggregation of rat blood platelets and the endogenous formation of thromboxane B2 and 12-hydroxy-5,8,10,14-eicosatetraenoic acid

Prostaglandins, Leukotrienes and Essential Fatty Acids, 1988
Rat platelets were isolated and labelled with [1-14C] arachidonic acid. After aggregation thromboxane B2, 12-hydroxy 5,8,10-heptadecatrienoic acid (HHT) and 12-hydroxy-eicosatetraenoic acid (12-HETE) were the main metabolites formed. A comparison was made between several properties of the platelets of adrenalectomized and sham operated rats.
J E, Vincent, F J, Zijlstra
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Cutaneous responses to 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) and 5,12-dihydroxyeicosatetraenoic acid (leukotriene B4) in psoriasis and normal human skin

Archives of Dermatological Research, 1987
The arachidonate lipoxygenase products 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) and 5(S),12(R)-dihydroxy-6,8,10,14-eicosatetraenoic acid (leukotriene B4, LTB4) are potent leucocyte chemoattractants in vitro and in vivo. Both 12-HETE and LTB4-like material are found in increased amounts in lesional skin in psoriasis.
P M, Dowd, A K, Black, P W, Woollard, M W, Greaves   +3 more
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Selective stimulation of human platelet lipoxygenase product 12-hydroxy-5,8,10,14-eicosatetraenoic acid by chlorpromazine and 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982
Stimulation of human platelets by thrombin and by the Ca2+ ionophore A23187 leads to a rapid Ca2+-dependent activation of phospholipases that release membrane-bound arachidonic acid for oxidation by a cyclooxygenase and lipoxygenase enzymes into so-called eicosanoids.
J, Maclouf, H, De la Baume, S, Levy-Toledano, J P, Caen   +3 more
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Rapid method for automated on-line extraction and fractionation of plasma leukotrienes and 12-hydroxy-5,8,10,14-eicosatetraenoic acids by reversed-phase high-performance liquid chromatography

Journal of Chromatography B: Biomedical Sciences and Applications, 1992
A method is described for automated on-line extraction and fractionation of plasma leukotrienes (LTs) and (5Z,8Z,10E,14Z)-(12S)-hydroxy-5,8,10,14-eicosate traenoic acid [12(S)-HETE] by reversed-phase high-performance liquid chromatography (RP-HPLC).
E L, VanAlstyne, S M, Spaethe
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Arachidonic acid metabolism in isolated pancreatic islets. V. The enantiomeric composition of 12-hydroxy-5,8,10,14-eicosatetraenoic acid indicates synthesis by a 12-lipoxygenase rather than a monooxygenase

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1989
Recent evidence indicates that the arachidonate metabolite 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) or its precursor may act as a second messenger in stimulus-response coupling in a variety of cells including Aplysia neurons, adrenal glomerulosa cells, and pancreatic islets.
J, Turk, B A, Wolf, R A, Easom, J H, Hughes, M L, McDaniel   +4 more
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Quantitative stereochemical analysis of subnanogram amounts of 12-hydroxy-(5,8,10,14)-eicosatetraenoic acid by sequential chiral phase liquid chromatography and stable isotope dilution mass spectrometry

Analytical Biochemistry, 1988
The two enantiomers of 12-hydroxy-(5,8,10,14)-eicosatetraenoic acid (12-HETE) are products of different biosynthetic pathways and have distinct biologic actions. Conventional methods of stereochemical analysis of 12-HETE require multimicrogram amounts of material and cannot be applied to systems where the availability of tissue is limited and only ...
J, Turk, W T, Stump, B A, Wolf, R A, Easom, M L, McDaniel   +4 more
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The Stereochemical Analysis of Monohydroxyfatty Acids, Particularly 12-Hydroxy-5,8,10,14-Eicosatetraenoic Acid

1988
Monohydroxy acids are major lipoxygenase-like metabolites in extracts from the skin of psoriatic patients. An interest in the origin and therefore mechanism of formation of these compounds stimulated investigation of their stereochemistry. Chiral methods using HPLC have been developed for separation and quantification of the hydroxyl enantiomers as ...
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Increased activity and stimulability of psoriatic epidermal soluble guanylate cyclase by arachidonic acid and 12-hydroxy-5,8,10,14-eicosatetraenoic acid.

Advances in cyclic nucleotide research, 1980
Soluble guanylate cyclase activity was measured in normal and psoriatic human epidermis. The specific activity of guanylate cyclase was determined to be increased 10-fold and 3-fold in involved and uninvolved epidermis of psoriatics, respectively, compared with normal epidermis.
J S, Cantieri, G, Graff, N D, Goldberg
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Identification and measurement of 12-hydroxy-5,8,10,14-eicosatetraenoic acid in whole blood: implications for the radioimmunoassay of leukotriene B4

Biochemical Society Transactions, 1987
F. CAREY, R. A. FORDER, D. HAWORTH, P. M. WOOLLARD   +3 more
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