Results 81 to 90 of about 10,508,137 (290)

Association between the incidence of hypertension and alcohol consumption pattern and the alcohol flushing response: A 12-year follow-up study

Alcohol, 2020
Alcohol consumption is associated with hypertension, and this association depends on the alcohol consumption pattern and alcohol flushing response. In this 12-year follow-up study, we investigated the relationship between the alcohol consumption pattern and incidence of hypertension in the Korean population.We analyzed 1,366 Korean participants in the ...
Min-Gyu Yoo, Yoo Jeong Lee, Han Byul Jang, Hyo-Jin Kim, Hye-Ja Lee, Sang Ick Park   +5 more
openaire   +2 more sources

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Modeling the Factors That Determine Sustainable Development Goal 12 in University Students

Education Sciences
SDG12 is one of the top three Sustainable Development Goals that require more urgent action. Hence, this work aims to develop and validate a conceptual model that measures the main factors which may influence university students’ sustainable consumption ...
Monica Martinez Gomez, Ma Angeles Alcaide Gonzalez, Elena de la Poza Plaza   +2 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

The impact of voluntary sustainability adjustments on greenhouse gas emissions from food consumption – The case of Denmark

In this study we ask how a range of environmental sustainability adjustments that consumers find it easy to adoptaffect the carbon footprint of their food consumption.
Nordström, Jonas, Denver, Sigrid
core   +2 more sources

Sustainable urban waste collection using a hybrid heuristic–genetic approach: a Bangkok case study

Frontiers in Sustainability
Urban waste collection is a critical component of sustainable city development, directly influencing emissions reduction, resource efficiency, and public health.
Chaowalit Hamontree, Jarotwan Koiwanit, Ananta Sinchai   +2 more
doaj   +1 more source

CONSUMER PSYCHOLOGY IN GREEN ADVERTISING (SDG 12 RESPONSIBLE CONSUMPTION & PRODUCTION)

Lex localis - Journal of Local Self-Government
This study explores the role of consumer psychology in shaping responses to green advertising within the framework of Sustainable Development Goal 12: Responsible Consumption and Production. Green advertising, encompassing eco-labels, environmental claims, and sustainability-driven campaigns, seeks to influence consumer awareness, attitudes, and ...
Dr.Nidhi Chaturvedi, Dr. Irbha Magotra, Huang Xibin   +2 more
openaire   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source