Results 271 to 280 of about 134,692 (313)

Identification of Methylglyoxal Reactive Proteins with Photocaged Glycating Agents

ChemBioChem, EarlyView.
Photocaged methylglyoxal (PC‐MGO) derivatives enable studying protein glycation under mild conditions. The active glycating agents can be released in the protein solution by irradiating the sample with UV light. Compared to the earlier reported chemically activated MGO probes, the photocaged probes are more potent.
Saskia Sokoliova, I. Raluca Sardaru, Franciszek P. Warguła, Jos H. Hermans, Hjalmar P. Permentier, Peter L. Horvatovich, Martin D. Witte   +6 more
wiley   +1 more source

ThiF‐Like Enzyme Chemistry in Primary and Secondary Metabolism

ChemBioChem, EarlyView.
ThiF‐like enzymes are a widespread protein family found in disparate biosynthetic pathways. They are unified by their use of an NTP to modify a carboxylate, generating an activated species prone to nucleophilic addition. This common intermediate is then targeted by diverse nucleophiles, including persulfide or amino acid side chains, to yield a variety
Keelie S. Butler, Anshul Rajput, Jonathan R. Chekan   +2 more
wiley   +1 more source

Amidine Syntheses from Classic to Contemporary for Medicinal Lead Compounds and Natural Products

European Journal of Organic Chemistry, EarlyView.
A revolution is underway in the synthesis of amidines with new methods unlocking complex, highly substituted amidines or closely related derivatives such as N‐sulfonyl amidines. This review surveys recent advances in amidines and related compounds, including methods to install them and bioactive molecules prominently featuring the amidine functionality.
Wyatt R. Swift‐Ramirez, Gregory A. Weiss   +1 more
wiley   +1 more source

Biochemical characteristics and applications of microalga Chlorella sorokiniana KNUA228 isolated from Ulleungdo

Environmental Progress &Sustainable Energy, EarlyView.
Abstract The increasing environmental and health challenges posed by fossil fuel dependency necessitate the exploration of renewable bioresources. Chlorella sorokiniana KNUA228, a microalga isolated from Ulleungdo, Republic of Korea, was investigated to evaluate its biotechnological potential. Molecular analyses confirmed its identity as C. sorokiniana,
Jin‐Won Lee, Jeong‐Mi Do, Ho‐Seong Suh, Yu‐Hee Seo, Su‐Bin Park, Ho‐Sung Yoon   +5 more
wiley   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis

Exploration, EarlyView.
NaCr promotes KCr to impede the inflammatory progression of ulcerative colitis. KCr induces mitophagy by activating the PINK1/PARKIN pathway to restrict NLRP3 inflammasome activation, thereby decreasing the production and release of various inflammatory cytokines, such as IL‐1β and TNF‐α. KCr induces mitophagy and inhibits NLRP3 inflammasome activation
Tongtong Liu, Binyan Lin, Ying Zhang, Jiayu Su, Xiaochao Hu, Xuan Wang, E‐Hu Liu, Shijia Liu   +7 more
wiley   +1 more source

Modulation of Gut Microbiota by Protein‐Oligosaccharide Maillard‐Reaction‐Derived Probiotic Microcapsules

Food Bioengineering, EarlyView.
Development of a novel synbiotic microcapsule and its impact on gut microbiota. ABSTRACT As a new type of prebiotic, the Maillard reaction products of protein ‐ oligosaccharide conjugates have emerged as a promising material for probiotic encapsulation and improve host health.
Hongxing Zhang, Yue Shen, Wanting Huang, Xinyi Fang, Yanlin Wang, Xingyuan Ma, Wenyun Zheng   +6 more
wiley   +1 more source

Postbiotic from Lactobacillus acidophilus Inhibits Ferroptosis in Intestinal Stem Cells via Microbiota–AhR Axis to Mitigate Colitis

Food Frontiers, EarlyView.
Lacidophilin tablets alleviate colitis by regulating gut microbiota balance and maintaining intestinal barrier integrity. ABSTRACT Inflammatory bowel disease (IBD) is a chronic, progressive intestinal disorder. Dysbiosis of the gut microbiota is strongly implicated in the onset and progression of IBD.
Denglong Sun, Chenxuan Wang, Qigui Fan, Yang Zhan, Xiaoying Cheng, Jingwen Zhang, Qinxin Wang, Yingmeng Li, Qiong Li, Yanxia Xiong, Wenjun Liu   +10 more
wiley   +1 more source

Sojae Semen Praeparatum Fermented by Rhizopus chinensis and Bacillus sp. DU‐106 Alleviates Loperamide‐Induced Constipation in Rats via Regulating Calcium Signaling Pathways and the Gut Microbiota

Food Frontiers, EarlyView.
To investigate the effects of different processing methods of Sojae Semen Praeparartum (SSP) on constipation, we prepared SSP through fermentation using Rhizopus chinensis and Bacillus sp. DU‐106 as starter cultures, and examined its laxative effects and mechanisms in loperamide‐induced constipated Sprague‐Dawley (SD) rats.
Rong xiang Guo, Chao fan Zhao, Yan li Li, Yun xi Zhang, Fu Yao Luo, Yi hang Sun, Ya fei Wang, Jun Yuan Huang, Bing Du, Pan Li   +9 more
wiley   +1 more source

Fermentation of Soy Juice by Lactiplantibacillus plantarum CIRM‐BIA777 Produces Flavor‐Related and Health‐Promoting Metabolites

Food Frontiers, EarlyView.
Transcriptomics revealed the metabolism of Lactiplantibacillus plantarum during soy milk fermentation. The fermentation of soy milk released aroma compounds and health‐beneficial metabolites. ABSTRACT The fermentation of plant‐based beverages, such as organic and locally produced soy juice (SJ), offers a sustainable way to develop dairy alternatives ...
Olivier Harlé, Sandrine Parayre, Marie‐Bernadette Maillard, Gwenaële Henry, Éric Guédon, Anne Thierry, Jérôme Niay, Stéphanie‐Marie Deutsch, Hélène Falentin   +8 more
wiley   +1 more source