Results 211 to 220 of about 1,076,866 (305)

Combinatorial Tuning of Multigene Biosynthetic Pathways based on RNA Interference

open access: yesAdvanced Science, EarlyView.
Small RNA sequencing identifies candidate endogenous Pol III promoters, and subsequent fluorescence screening measures knockdown efficiency to assess promoter strength. Combining promoter strength and shRNA target position enables fine‐grained RNAi regulation of multigene pathways. This strategy enhances β‐carotene production in Schizochytrium sp.
Zixu Zhang   +6 more
wiley   +1 more source

CKMT1 Counteracts VDAC1 Oligomerization‐Induced Neuronal Pyroptosis Through Steric Hindrance in Ischemic Stroke

open access: yesAdvanced Science, EarlyView.
CKMT1 inhibits VDAC1 oligomerization via a dual‐region mechanism: its NTD interacts with the VDAC1 C‐terminal domain, while residues 1–39 sterically hinder dimerization, thereby reducing mtDNA leakage and AIM2 inflammasome activation, suppressing neuronal pyroptosis and protecting against cerebral ischemic injury. ABSTRACT Ischemic stroke is one of the
Xiaoyu Wang   +17 more
wiley   +1 more source

Beyond Blood Cultures: The Promise of 16S rRNA Sequencing. [PDF]

open access: yesJACC Case Rep
Hamana T   +3 more
europepmc   +1 more source

Mechanistic Insights Into the Regulation of Tyramine Production by NaCl in Enterococcus From Sufu: Growth, Gene Expression, and Enzymatic Activity

open access: yesAgriFood: Journal of Agricultural Products for Food, EarlyView.
Although 6%–8% NaCl concentration suppressed Enterococcus growth, the content of tyramine production was higher than that under 0% NaCl, with the maximum production observed at 8% NaCl. This result was driven by the upregulation of tyrDC, tyrP, and nhaC genes and the stabilization of TDC enzymatic activity. ABSTRACT High salt content in sufu suppresses
Mingxi Liu   +6 more
wiley   +1 more source

Small Intestinal Bacterial Overgrowth Following Gastrointestinal Cancer Surgery: Current Evidence and Future Perspectives

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Small intestinal bacterial overgrowth (SIBO) has recently gained increasing attention as a potential cause of postoperative gastrointestinal symptoms following gastrointestinal cancer surgery. Surgical procedures can disrupt normal gastrointestinal physiology through anatomical reconstruction, impaired motility, reduced gastric acid secretion,
Toru Aoyama   +2 more
wiley   +1 more source

A well‐resolved phylogeny of Cuscuta subgenus Monogynella based on data drawn from all three plant genomes

open access: yesAmerican Journal of Botany, EarlyView.
Abstract Premise Cuscuta (dodders) consists of ~200 species circumscribed into four subgenera (Monogynella, Cuscuta, Pachystigma, and Grammica) and is the only parasitic genus in Convolvulaceae (the morning‐glory family). This group shows a significant diversity in plastid functionality and represents a rare mixotrophic system among parasitic plants ...
Asawari Albal, Saša Stefanović
wiley   +1 more source

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