Results 51 to 60 of about 4,422 (206)

Progesterone and Preterm Birth Prevention: Translating Clinical Trials Data into Clinical Practice [PDF]

, 2012
OBJECTIVE: We sought to provide evidence-based guidelines for using progestogens for the prevention of preterm birth (PTB). METHODS: Relevant documents, in particular randomized trials, were identified using PubMed (US National Library of Medicine, 1983
Berghella, Vincenzo
core   +1 more source

Evaluation of a non‐radioactive rapid test for determination of serum progesterone in South American camelids

Veterinary Record, EarlyView.
Abstract Background Determination of the serum progesterone (P4) concentration is of high importance in reproductive medicine and may be applied for diagnosing pregnancy in South American camelids. P4 measurements in alpacas and llamas are usually performed using immunoassays, which are time consuming and require appropriate expertise of laboratory ...
Lina Längerer, Gerhard Schuler, Philipp Pohlscheid, Henrik Wagner, Kathrin Büttner, Axel Wehrend   +5 more
wiley   +1 more source

Prenatal 17‐Alpha‐Hydroxyprogesterone Caproate Exposure in Twins and Childhood Outcomes: 14‐Year Follow‐Up of a Randomised Trial

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Long‐term child outcomes after intra‐uterine exposure to 17‐alpha‐hydroxyprogesterone caproate (17‐OHPC) versus placebo. Design Follow‐up of the AMPHIA randomised controlled trial assessing neonatal outcomes after weekly 17‐OHPC injections compared to placebo in multiple pregnancies. Setting Multicentre. Population or Sample Children
Emilie V. J. van Limburg Stirum, Marjon A. de Boer, A. C. J. Ravelli, Rik van Eekelen, Aleid G. Leemhuis, Martijn J. J. Finken, Cornelieke S. H. Aarnoudse‐Moens, Anneloes L. van Baar, Noor E. Simons, Rebecca C. Painter, Arianne C. Lim, Ben W. Mol, Eva Pajkrt, Martijn A. Oudijk, Janneke van 't Hooft   +14 more
wiley   +1 more source

Progesterone effects on vaginal cytokines in women with a history of preterm birth.

PLoS ONE, 2018
ObjectiveTo determine the effect of intramuscular progesterone on the vaginal immune response of pregnant women with a history of prior preterm birth.MethodsA prospective, cohort study of women at 11-16 weeks gestation, ≥18 years of age, and carrying a ...
David J Garry, David A Baker, Malini D Persad, Tatyana Peresleni, Christina Kocis, Michael Demishev   +5 more
doaj   +1 more source

Revisiting the placental clock: Early corticotrophin-releasing hormone rise in recurrent preterm birth.

PLoS ONE, 2021
ObjectiveTo determine if maternal plasma CRH and preterm birth history were associated with recurrent preterm birth risk in a high-risk cohort.Study designSecondary analysis of pregnant women with a prior preterm birth ≤35 weeks receiving 17-alpha ...
Christina L Herrera, Maria E Bowman, Donald D McIntire, David B Nelson, Roger Smith   +4 more
doaj   +1 more source

Steroid Recognition in Adhesion GPCRs: A Structural and Pharmacological Perspective

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT Emerging evidence suggests steroids may act as generalizable ligands for adhesion GPCRs, a receptor class with considerable pharmacological potential. While most studies have focused on the ADGR‘G' subfamily, recent cryo‐EM structures of the androgens 5α‐dihydrotestosterone (5α‐DHT) and methenolone bound to ADGRD1 revealed a putative steroid ...
Bethany Fleming, Abdul‐Akim Guseinov, Irina G. Tikhonova, Graeme Milligan, Nicole A. Perry‐Hauser   +4 more
wiley   +1 more source

Optimization of Monoclonal Antibodies Purification Expressed in H-192 cells using Preparative Native-Polyacrylamide Gel Electrophoresis [PDF]

, 2015
Monoclonal antibodies (mAbs) are unique and specific drug molecules targeting the treatment of various diseases such as arthritis, immune disorders, infectious diseases, and cancer etc.
Chew, Few Ne, Chua, Gek Kee, Mimi Sakinah, A. M., Santhana, Krishnan, Zularisam, A. W.   +4 more
core  

Vaginal progesterone pessaries for pregnant women with a previous preterm birth to prevent neonatal respiratory distress syndrome (the PROGRESS Study): A multicentre, randomised, placebo-controlled trial [PDF]

, 2017
Published: September 26, 2017Background: Neonatal respiratory distress syndrome, as a consequence of preterm birth, is a major cause of early mortality and morbidity.
Ashwood, P., Crowther, C., Dodd, J., Flenady, V., McPhee, A., Robinson, J., Tran, T.   +6 more
core   +1 more source

Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone–Binding Globulin Expression

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Sex hormone–binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61) and expression in in vitro experiments in human 3D hepatocyte spheroids and HepG2 cells.
Maria H. Ahonen, Anja Konzack, Tomas Smutny, Petr Pavek, Jukka Hakkola, Janne Hukkanen   +5 more
wiley   +1 more source

Effects of exercise during pregnancy in women with short cervix: Secondary analysis from the Italian Pessary Trial in singletons [PDF]

, 2018
OBJECTIVE: To evaluate effects of exercise during pregnancy in asymptomatic singleton pregnancies without prior spontaneous preterm birth (SPTB) but with short transvaginal ultrasound cervical length (TVU CL).
Arduino, Bruno, Berghella, Vincenzo, D'Alessandro, Pietro, Giudicepietro, Antonia, Martinelli, Pasquale, Raffone, Antonio, Saccone, Gabriele, Venturella, Roberta, Visentin, Silvia, Vitagliano, Amerigo, Zullo, Fulvio   +10 more
core   +1 more source