Results 51 to 60 of about 3,749 (163)

¿La progesterona natural micronizada previene el trabajo de parto pretérmino?: Revisión sistemática de literatura

MedUNAB, 2022
Introducción. La progesterona es una hormona que favorece el mantenimiento del embarazo, es la protagonista de la fisiopatología del trabajo de parto pretérmino.
Villamizar-Jiménez, María Alejandra, Wandurraga-Vargas, Valentina, Vargas-Rey, Javier Enrique, Guarín-Serrano, Rocío   +3 more
doaj   +1 more source

Liver cirrhosis is associated with altered glucocorticoid metabolism related to disease severity

Journal of Internal Medicine, Volume 300, Issue 4, Page 513-527, October 2026.
Abstract Background Liver cirrhosis (LC) is frequently complicated by adrenal dysfunction; however, whether cirrhosis drives the coordinated, pathway‐specific reprogramming of cortisol metabolism remains unclear. Objectives We aimed to characterize axis‐specific alterations in cortisol metabolism in patients with LC, those with adrenal insufficiency ...
Soyeon Park, Min Jeong Park, Hye Won Yang, Jeayeon Park, Su Jong Yu, Seung Shin Park, Man‐Ho Choi, Eun Ju Cho, Jung Hee Kim   +8 more
wiley   +1 more source

An Efficient Detection Platform Based on Mesoporous Au@Cr2O3 Particles with Schwarz P Surface for Precise Periodontitis Metabolite Profiling

Advanced Science, Volume 13, Issue 54, 28 September 2026.
A non‐invasive periodontitis diagnosis platform was developed using Au nanoparticles‐decorated mesoporous Cr2O3 (Au@mCr2O3) particles with Schwarz P surface as matrix for saliva metabolic fingerprinting (SMFs) analysis via MALDI‐MS. With the assistance of machine learning of SMFs, this platform enables efficient diagnosis and the screening of potential
Yue Sun, Yan Wang, Fangying Shi, Wenhe Xie, Yiding Zhang, Heyuhan Zhang, Chunhui Deng, Limin Wu, Meihua Chen, Yonghui Deng   +9 more
wiley   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Mono-(2-ethylhexyl) phthalate directly alters the expression of Leydig cell genes and CYP17 lyase activity in cultured rat fetal testis.

PLoS ONE, 2011
Exposure to phthalates in utero alters fetal rat testis gene expression and testosterone production, but much remains to be done to understand the mechanisms underlying the direct action of phthalate within the fetal testis.
François Chauvigné, Simon Plummer, Laurianne Lesné, Jean-Pierre Cravedi, Nathalie Dejucq-Rainsford, Alexis Fostier, Bernard Jégou   +6 more
doaj   +1 more source

Revisiting the placental clock: Early corticotrophin-releasing hormone rise in recurrent preterm birth.

PLoS ONE, 2021
ObjectiveTo determine if maternal plasma CRH and preterm birth history were associated with recurrent preterm birth risk in a high-risk cohort.Study designSecondary analysis of pregnant women with a prior preterm birth ≤35 weeks receiving 17-alpha ...
Christina L Herrera, Maria E Bowman, Donald D McIntire, David B Nelson, Roger Smith   +4 more
doaj   +1 more source

The Clinical Phenotype and Genetic Analysis of Monogenic Non Syndromic Obesity Caused by MC4R Gene Variation

Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.
A novel MC4R mutation (c.185A > G) was identified in a 10‐year‐old girl with severe obesity and hyperinsulinemia. Retrospective analysis of 64 pediatric cases revealed that mutation location influences BMI, modulated by underlying disease status, demonstrating that the genotype–phenotype relationship in MC4R‐associated obesity is clinically context ...
Xin Li, Xiaotian Wang, Xin Liu, Shuping Wang, Wentao Yang   +4 more
wiley   +1 more source

Sexual Dimorphisms of Adrenal Steroids, Sex Hormones, and Immunological Biomarkers and Possible Risk Factors for Developing Rheumatoid Arthritis

International Journal of Endocrinology, 2015
Innate immunity and immunological biomarkers are believed to be interrelated with sex hormones and other neuroendocrine factors. Sexual dimorphism mechanisms may be operating in certain rheumatic and inflammatory diseases which occur more frequently in ...
Alfonse T. Masi, Azeem A. Rehman, Laura C. Jorgenson, Jennifer M. Smith, Jean C. Aldag   +4 more
doaj   +1 more source

A radio-immunoassay of 17-alpha-hydroxyprogesterone.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1980
A method is described for the determination of 17 alpha-hydroxyprogesterone (17-OHP) in plasma. Antisera were raised in rabbits against 11-deoxycortisol-21-hemisuccinate-bovine serum albumin (11-DOC-21-HS-BSA) and 17 alpha-hydroxyprogesterone-3-carboxymethyloxime-bovine serum albumin (17-OHP-3-CMO-BSA).
J L, Barron, C, Kewley, R P, Millar, P, Gray   +3 more
openaire   +1 more source

Determination of serum 17 alpha-hydroxyprogesterone by liquid chromatography.

Clinical Chemistry, 1981
Abstract 17 alpha-Hydroxyprogesterone, cortisol, and 11-deoxycortisol were extracted with methylene chloride, separated by liquid chromatography, identified by their retention times, and quantitated by monitoring the absorbance at 254 nm. The method is specific and sensitive to as little as 2.5 ng of 17 alpha-hydroxyprogesterone.
E, Canalis, A M, Caldarella, G E, Reardon   +2 more
openaire   +2 more sources