Results 81 to 90 of about 122,279 (340)

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Synergistic interaction network between the snR30 RNP, Utp23, and ribosomal RNA during ribosome synthesis

RNA Biology, 2022
snR30/U17 is a highly conserved H/ACA RNA that is required for maturation of the small ribosomal subunit in eukaryotes. By base-pairing to the expansion segment 6 (ES6) of 18S ribosomal RNA (rRNA), the snR30 H/ACA Ribonucleoprotein (RNP) indirectly ...
Timothy J. Vos, Ute Kothe
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Amplifikasi Fragmen Gen 18s Rrna Pada Dna Metagenomik Madu Dengan Teknik Pcr (Polymerase Chain Reaction) [PDF]

, 2017
The aim of this research was to amplificate 18S rRNA gene fragment from honey's metagenomic DNA using Polymerase Chain Reaction (PCR). The honey sample was collected from Seraya Tengah village, Karangasem regency. The best result of primer design from in
Prakoso, S. P. (Satriya), Suarsa, I. W. (I), Wirajana, I. N. (I)   +2 more
core  

5′‐Cleavage site of D. melanogaster 18 S rRNA

FEBS Letters, 1984
We determined the nucleotide sequence of the DNA region around the 5′‐terminus of 18 S rRNA in two cloned rDNA gene units of Drosophila melanogaster. The 5′‐base is within a sequence CATTATT which is present also at the 3′‐terminus of the 18 S rRNA coding region. In this case it is known that the situation is CATTA3′ · TT.
Simeone, A., Boncinelli, E.
openaire   +2 more sources

Origin of the Mesozoa inferred from 18S rRNA gene sequences [PDF]

Molecular Biology and Evolution, 1996
The phylum Mesozoa comprises small, simply organized wormlike parasites of marine invertebrates and is composed of two classes, the Rhombozoa and the Orthonectida. The origin of Mesozoa is uncertain; they are classically considered either as degenerate turbellarians or as primitive multicellular animals related to ciliated protists.
Pawlowski, Jan Wojciech, Montoya Burgos, Juan Ignacio, Fahrni, José, Wuest, Jean, Zaninetti, Louisette   +4 more
openaire   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Arabidopsis RIBOSOMAL RNA PROCESSING7 Is Required for 18S rRNA Maturation [PDF]

The Plant Cell, 2018
Ribosome biogenesis is fundamental to growth and development in eukaryotes and is linked to human diseases and cancer. Arabidopsis thaliana MORPHOLOGY OF ARGONAUTE1-52 SUPPRESSED 2 (MAS2) participates in splicing and 45S ribosomal DNA (rDNA) expression.
Rosa Micol-Ponce, Raquel Sarmiento-Mañús, Alejandro Ruiz-Bayón, Charlotte Montacié, Julio Sáez-Vasquez, María Rosa Ponce   +5 more
openaire   +3 more sources

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Maturation of the 90S pre-ribosome requires Mrd1 dependent U3 snoRNA and 35S pre-rRNA structural rearrangements [PDF]

, 2018
In eukaryotes, ribosome biogenesis requires folding and assembly of the precursor rRNA (pre-rRNA) with a large number of proteins and snoRNPs into huge RNA-protein complexes. In spite of intense genetic, biochemical and high-resolution cryo-EM studies in
Barandun, Beltrame, Beltrame, Ben-shem, Borovjagin, Borovjagin, Borovjagin, Burlacu, Chaker-Margot, Cheng, Coleman, Dragon, Dutca, Elena Burlacu, Fredrik Lackmann, Gavin, Grandi, Granneman, Granneman, Gulen, Hartshorne, Hartshorne, Hector, Henras, Hoang, Hughes, Hughes, Intine, Jin, Kornprobst, Koš, Krogan, Kudla, Lars Wieslander, Longtine, Low, Lundkvist, Lusvarghi, Létoquart, Marmier-Gourrier, Mortimer, Méreau, Osheim, Pestov, Pérez-Fernández, Sahasranaman, Sander Granneman, Sardana, Sardana, Sardana, Segerstolpe, Segerstolpe, Selega, Sergey Belikov, Shah, Sharma, Sharma, Smola, Sun, Tang, Tschochner, Velichutina, Wang, Wieslander, Woolford, Yeh   +65 more
core   +1 more source