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19-Norandrosterone (19-NA) is the major metabolite of the steroid nandrolone, one of the most commonly abused anabolic androgenic agents. 19-NA exists mainly as the glucuronide form in human urine. A candidate reference measurement procedure for 19-NA in urine involving isotope dilution coupled with liquid chromatography/tandem mass spectrometry (LC/MS/
Susan S.-C. Tai +3 more
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AbstractTandem mass spectrometric methods for the identification of 19‐nortestosterone (estr‐4‐en‐17β‐3‐one) are described and evaluated. The fragmentation reactions of the heptafluorobutyryl (HFB) and pentafluorobenzyloxime heptafluorobutyryl (PFBOHFB) ester derivatives of 19‐nortestosterone in particular were studied for the purpose to select ...
Douwe de Boer +4 more
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Identification of endogenous 19-norandrosterone in human urine
Bruno Le Bizec +4 more
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Modulation of phase II metabolism: A case study on 19-norandrosterone
201419-norandrosterone is the main phase I metabolite of the synthetic androgenic anabolic steroid (AAS) 19-nortestosterone (or nandrolone). Once formed 19-norandrosterone undergoes conjugation reaction catalyzed mainly by the uridine diphospho glucuronosyltransferases (UDPGTs) to form the corresponding glucuro-conjugated. Due to the fact that the presence
Mazzarino, M +5 more
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Nandrolone criteria for 19-norandrosterone Isotope Ratio Mass Spectrometric confirmation
2014The detection of the use of nandrolone and other 19-norsteroids is based primarily upon the identification of the main urinary metabolite, 19-norandrosterone (19-NA) in a concentration (derived from hydrolysis with β-glucuronidase) greater than the Decision Limit (DL), as established in the DL Technical Document.
X. de la Torre +7 more
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2002
A specific and sensitive method was developed for the quali-quantitative determination in urine of 19- norandrosterone (19-NA) and 19-noretiocholanolone (19-NE), main metabolites of the anabolic androgenic steroid nandrolone as well as of other 19-norsteroids. The total steroid fraction, extracted from urine, after addition of Ds-noretiocholanolone, by
Tedeschi L +5 more
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A specific and sensitive method was developed for the quali-quantitative determination in urine of 19- norandrosterone (19-NA) and 19-noretiocholanolone (19-NE), main metabolites of the anabolic androgenic steroid nandrolone as well as of other 19-norsteroids. The total steroid fraction, extracted from urine, after addition of Ds-noretiocholanolone, by
Tedeschi L +5 more
openaire +1 more source
19-Norandrosterone origin: a simple procedure for GC/C/IRMS sample preparation by HPLC
2011de la Torre X +6 more
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