Results 231 to 240 of about 77,981 (327)

Venetoclax combined with cladribine, idarubicin, cytarabine (CLIA‐VEN) results in higher remission rates over conventional 7 + 3 chemotherapy without increased toxicity in newly diagnosed acute myeloid leukaemia

British Journal of Haematology, EarlyView.
Summary Induction chemotherapy in fit de novo acute myeloid leukaemia (AML) patients has historically combined an anthracycline with standard‐dose cytarabine (‘7 + 3’) despite complete response (CR) rates of 50%–70%. In May 2023, our institution adopted the utilization of cladribine, cytarabine, idarubicin and venetoclax (CLIA‐VEN) for intensive ...
Benjamin J. Lee, Shawn P. Griffin, Jean Doh, Anthony Quach, Yujiao Sun, Piyatida Chumnumsiriwath, Stefan O. Ciurea, Jorge Ramos‐Perez, Polina Bellman, Deepa Jeyakumar, Piyanuch Kongtim, Kiran Naqvi   +11 more
wiley   +1 more source

Ph-triazole as a therapeutic agent for pancreatic cancer: Synthesis, in silico, and in vitro evaluation. [PDF]

PLoS One
Zhang N, Li X, Li F, Jin J, Zheng T, Zhou L.   +5 more
europepmc   +1 more source

Crystal structure of diaqua-bis(5′-(pyridin-1-ium-4-yl)-1H-[3,3′-bi(1,2,4-triazol)]-2′-ide-κ² N,N′)cobalt(II) — bis(5-(pyridin-4-yl-κN)-1H,1′H-3,3′-bi(1,2,4-triazole))octamolybdate – water (2/1/8), C₂₇H₃₃CoMo₄N₂₁O₁₉

, 2017
Shan-Xiu Huang, Lanhe Zhang, Mingjie Ma, Dan Zhao   +3 more
openalex   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source

Study of Structural, Vibrational, and Molecular Docking Properties of (1<i>S</i>,9a<i>R</i>)-1-({4-[4-(Benzyloxy)-3-methoxyphenyl]-1<i>H</i>-1,2,3-triazol-1-yl}methyl)octahydro-2<i>H</i>-quinolizine. [PDF]

Molecules
Turdybekov D, Nurmaganbetov Z, Makhmutova A, Baev D, Gatilov Y, Pankin D, Smirnov M, Bekisheva P, Kopbalina K.   +8 more
europepmc   +1 more source

A novel one-pot three-components reaction: synthesis of indeno[2',1':5,6]pyrido[2,3:4'',5'']pyrimido[2'',1''-c]triazole-5,7-dione. A new ring system

, 2007
Huwaida M. E. Hassaneen
openalex   +2 more sources

A practical guide to molecular docking and homology modelling for medicinal chemists [PDF]

, 2017
Levonis, Stephan M, Lohning, Anna E, Schweiker, Stephanie S, Williams-Noonan, Billy   +3 more
core   +1 more source

Synthesis and Herbicidal Activity of New 2-(1-Carbamoyl-1, 2, 4-triazol-3-ylsulfonyl) alkanoates

Journal of Pesticide Science, 2002
Tomoyuki YANO, Tomoko YOSHII, Takuya UEDA, Masahiro HORI, Kenji HIRAI   +4 more
openaire   +2 more sources

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Design, synthesis, <i>in silico</i> studies, and antiproliferative activity of a novel series of thiazole/1,2,3-triazole hybrids as apoptosis inducers and multi-kinase inhibitors endowed with anti-breast cancer activity. [PDF]

RSC Adv
Mohamed FAM, Alakilli SYM, Alhassan HH, Yousif SO, Alatwi E, Gomaa HAM, Alrub HA, Alyami BA, Abdelhafez AH, Bräse S, Youssif BGM.   +10 more
europepmc   +1 more source