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Reaction of 3-amino-1:2:4-triazole with lactoperoxidase

Archives of Biochemistry and Biophysics, 1973
Bovine lactoperoxidase (LPO) gradually lost its enzymatic activity when dialyzed against a solution of 3-amino-1:2:4-triazole (AT) and hydrogen peroxide at pH 7.0. Amino acid analysis of the completely inactive enzyme revealed the formation of a new ninhydrin-positive chromatographic peak.
J Y, Chang, W A, Schroeder
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Synthesis of some nitro and amino derivatives of 1, 2, 4-triazole-5-thiones and 1, 2, 4-triazoles

Chemistry of Heterocyclic Compounds, 1967
Isomeric 3-(nitrophenyl)-1, 2, 4-triazole-5-thiones are synthesized by cyclizing 1-nitrobenzoylthiosemicarbazides. 1-(4-Nitrophenyl)-1, 2, 4-triazole-3-thione is prepared by condensing 4-(4-nitrophenyl) thiosemicarbazide with formic acid. Oxidation converts the triazolethiones to nitrophenyltriazoles, and the latter are reduced to aminophenyltriazoles.
G. I. Chipen   +2 more
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Synthesis of 5-amino-1-(aminothioformyl)-1, 2, 4-triazoles

Chemistry of Heterocyclic Compounds, 1971
By the reaction of 5-amino-1, 2, 4-triazoles with benzoyl isothiocyanate we have synthesized 5-amino-1-(benzoylaminothioformyl)-1, 2, 4-triazoles, which form 5-amino-1-(aminothioformyl)-1, 2, 4-triazoles on alkaline hydrolysis.
G. I. Chipen   +2 more
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1 : 2 : 4-triazole as a corrosion inhibitor for copper

Corrosion Science, 1980
Abstract The solution chemistry of 1 : 2 : 4-triazole (TRZ) is investigated in the range of solution concentrations in which the compound acts as a corrosion inhibitor for copper. Parallel photo-electron spectroscopic studies show that although a surface layer of Cu(I) complex is formed at low TRZ concentrations, this is ineffective as an inhibitor ...
P.G. Fox, P.A. Bradley
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Basicity and structure of 1, 2, 4-triazole derivatives

Chemistry of Heterocyclic Compounds, 1967
Basicity constants for a number of 1, 2, 4-triazole derivatives are determined. An assumed amine structure for 3-amino-1, 2, 4-triazoles in aqueous solution is demonstrated. It is assumed that protonization of 3- and 4-amino-1, 2, 4-triazoles occurs at the nitrogen in the heterocyclic ring, and not at the amino group.
L. I. Bagal   +2 more
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The preparation of 3:5‐dimethyl‐1‐phenyl‐1:2:4‐triazole

Journal of Applied Chemistry, 1952
AbstractOptimum conditions for the laboratory‐scale preparation of 3 : 5‐dimethyl‐1‐phenyl‐1 : 2 : 4‐triazole by the Einhorn‐Brunner method have been studied. The mechanism of the reaction is different from those involved in the triazole syntheses of Pellizzari and Kaiser.
A. A. Komzak, J. B. Polya
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A Review on Synthetic Approaches and Activities of 1, 2, 4-Triazoles

Research Journal of Pharmacy and Technology, 2022
1, 2, 4-Triazoles and their derivatives have a distinct place in the field of medicinal and pharmaceutical chemistry. These are used as lead compounds for the synthesis of numerous heterocyclic compounds which possess diverse biological activities and play pivotal roles. This review covers the latest literature and knowledge on the synthetic procedures
Mahavir Singh   +3 more
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Die Röntgenstrukturanalyse von 1, 2, 4‐Triazol

Berichte der Bunsengesellschaft für physikalische Chemie, 1965
AbstractDie Kristallstruktur von 1, 2, 4‐Triazol, C2N3H3, wurde durch dreidimensionale Analyse der Röntgenbeugungsdaten ermittelt. Die Kristalle sind rhombisch (Raumgruppe Pbca‐D152h) mit 8 Molekülen in der Elementarzelle. Die Gitterkonstanten haben die Werte: a = 9,69 ± 0,04 Å, b = 9,38 ± 0,04 Å, c = 7,14 ± 0,03 Å.
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Inhibition of Cholinesterases by 1 : 2 : 4-Triazoles

Nature, 1955
IT has been repeatedly observed in my laboratory that workers, including non-smokers, manipulating 1 : 2 : 4-triazoles develop symptoms of light nicotine or physostigmine poisoning from time to time. Subsequent experiments have shown that some simple water-soluble 1 : 2 : 4-triazoles may act as inhibitors of cholinesterase activity.
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