Results 21 to 30 of about 25,343 (252)

Synthesis and physicochemical properties 4-((R))amino)-5-methyl-4H-1,2,4-triazole-3-thiols

Фармацевтичний журнал, 2018
Purposeful synthesis of derivatives of 1,2,4-triazole is one of the most important branches of modern pharmaceutical science Modern pharmaceutical market of domestic medicines requires constant updates of existing range.
T. V. Kravchenko, O. I. Panasenko, Ye. G. Knysh   +2 more
doaj   +1 more source

Some transformations and physicochemical properties of new S-substituted 5-thiophene-(3-ylmethyl)-4R-1,2,4-triazole-3-thiols

Фармацевтичний журнал, 2021
Nitrogen-containing heterocyclic compounds are widely represented in modern organic chemistry. A special place among the huge number of substances presented is occupied by derivatives of 1,2,4-triazole due to their uniqueness and prospects.
A. V. Khilkovets
doaj   +1 more source

Synthesis, physical-chemical properties of 2-((4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-yl)thio)acetohydrazides

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2017
Aim. Analysis of the scientific literature over the past decade has shown that large synthetic possibilities towards creating new and effective drug substances have heterocyclic compounds, in particular the derivatives of 1,2,4-triazole.
O. A. Suhak, O. I. Panasenko, Ye. G. Knysh   +2 more
doaj   +1 more source

Heterocyclizations based on N-(R-hydrazine-1-carbonothioyl)cycloalkancarboxamides: functionalized azoles and their antimicrobial activity

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2022
Synthesis and structural modification of azoles remains an important area of medical chemistry and allows to obtain new compounds with a wide range of biological activity.
О. V. Kholodniak, Yu. V. Shubina, S. I. Kovalenko   +2 more
doaj   +1 more source

Selected 5-amino-1-aryl-1H-1,2,3-triazole scaffolds as promising antiproliferative agents [PDF]

The Ukrainian Biochemical Journal, 2020
Development of a new effective drugs with low side effects and definite chemical characteristics needs indentification of bioactive scaffolds for further structural optimization.
N. Pokhodylo, O. Shyyka, N. Finiuk, R. Stoika   +3 more
doaj   +1 more source

Synthesis and antitumoral activity of novel biaryl hydroxy-triazole and fluorene-triazole hybrids [PDF]

Exploration of Drug Science
Aim: The development of selective and potent antitumor agents remains a significant challenge. This study aimed to synthesize and evaluate biaryl hydroxy-1,2,3-triazoles and 9H-fluorene-1,2,3-triazole hybrids, inspired by previously identified bioactive ...
David Chafi Zeitune, Marcelo Folhadella Martins Faria Azevedo, Mariane Senna Rangel, Robert de Sousa Bastos, José de Brito Vieira Neto, Claudia do Ó Pessoa, Camilla Djenne Buarque   +6 more
doaj   +1 more source

Synthesis of Bis (1,4-Disubstituted-1,2,3-triazoles) Starting from Diethyl Galactarate

Chemistry Proceedings, 2022
This communication reports the synthesis of a series of bis (1,4-disubstituted-1,2,3-triazoles) starting from the known (2,3,4,5) bis acetonide-protected diethyl galactarate (1).
Víctor Terraza, Darío Gerbino, Julio Podestá   +2 more
doaj   +1 more source

Evaluation Of Antioxidant Activity Of 1, 2, 4-Triazole Derivatives With Morpholine Moiety

Hacettepe University Journal of the Faculty of Pharmacy, 2022
The aim of the work was to study the antioxidant activity of 4-R-3- (morpholinomethyl)-4H-1,2,4-triazole-5-thioles and their alkyl derivatives in vitro using the method of non-enzymatic initiation of lipid peroxidation. Among the 45 compounds studied, 8 showed varying degrees of AOA.
SHCHERBYNA, Roman, PRUHLO, Yevhen, DUCHENKO, Maryna, KULAGİNA, Mariia, KUDRİA, Victoriia, VALENTYNA, Vashchuk   +5 more
openaire   +2 more sources

Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity [PDF]

Journal of Chemistry, 2007
Cyclisation of [4‐(4‐oxo‐2‐phenyl‐4H‐quinazolin‐3‐yl)‐phenoxy]‐acetic acid‐N′‐(substituted phenyl)‐thiosemicarbazides with sodium metal in 99.0 % ethanol gave 3‐[4‐(4‐substituted phenyl‐5‐thioxo‐4,5‐dihydro‐1H‐1,2,4 triazol‐3‐ylmethoxy)‐ phenyl]‐2‐phenyl‐3H‐quinazolin‐4‐one .
Freddy H. Havaldar, Abhay R. Patil
openaire   +2 more sources

Synthesis of new 1,4-disubstituted 1,2,3-triazoles using the CuAAC reaction and determination of their antioxidant activities

Anais da Academia Brasileira de Ciências, 2021
This study describes the synthesis and antioxidant activity of new 1,4-disubstituted 1,2,3-triazoles. These compounds were generated semi-synthetically using the Cu(I)-catalysed azide-alkyne cycloaddition (CuAAC) reaction between ethyl 2-azidoacetate and
JOSEFA A. DA CUNHA LIMA, JADSON DE FARIAS SILVA, COSME S. SANTOS, RODRIGO R.A. CAIANA, MARCÍLIO M. DE MORAES, CLAUDIO A.G. DA CÂMARA, JULIANO C.R. FREITAS   +6 more
doaj   +1 more source