Results 91 to 100 of about 190 (131)

Searching for innovative quinolone-like scaffolds: synthesis and biological evaluation of 2,1-benzothiazine 2,2-dioxide derivatives

MedChemComm, 2012
Quinolones are a widely used class of antibacterial agents characterized by overall favourable pharmacokinetic and pharmacodynamic characteristics. Unfortunately, both nosocomial and community acquired resistances to these agents are increasing. Thorough structure–activity relationship (SAR) studies have demonstrated that even drastic manipulation of ...
PIERONI, MARCO, SABATINI, STEFANO, MASSARI, SERENA, Glenn, W. Kaatz, CECCHETTI, Violetta, TABARRINI, Oriana   +5 more
openaire   +4 more sources

ChemInform Abstract: A Convenient Synthesis of 3,4‐Dihydro‐2,2‐dioxide‐5‐hydroxy‐2,1‐ benzothiazine.

ChemInform, 1994
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
D. BLONDET, J.‐C. PASCAL
openaire   +1 more source

Regioselective synthesis of pyrimido[5,4‐c][2,1]benzothiazines by reactions of β‐chloroaldehydes with n‐c‐n binucleophiles

Journal of Heterocyclic Chemistry, 2009
Abstract magnified imageThe method of pyrimidine ring fusion at the [c] side of benzothiazines based on the reaction of their chloroaldehyde derivatives with amidines is described. Formation of the structural isomers of reaction products was investigated, and regioselectivity of heterocyclization reactions was shown.
Kirill Popov, Tatyana Volovnenko, Alexander Turov, Yulian Volovenko   +3 more
openaire   +2 more sources

2,1-Benzothiazine 2,2-Dioxides. 8*. Synthesis and Structure of 2'-Amino-2-Oxo-1,2-Dihydro-6'H-Spiro-[Indole-3,4'-Pyrano[3,2-c][2,1]Benzothiazine]-3'-Carbonitrile 5',5'-Dioxides

Chemistry of Heterocyclic Compounds, 2014
2,2-Dioxides of 1-R-1H-2,1-benzothiazin-4(3H)-ones easily undergo a three-component condensation with N-substituted isatins and malononitrile in the presence of triethylamine giving 6'-R-1-R1-2'-amino-2-oxo-1,2-dihydro-6'H-spiro[indole-3,4'-pyrano[3,2-c][2,1]benzothiazine]-3'-carbonitrile 5',5'-dioxides in good yields. The reaction with 1-unsubstituted
I. V. Ukrainets, L. A. Petrushova, N. L. Bereznyakova, Liu Yangyang   +3 more
openaire   +1 more source

Synthesis, characterization, monoamine oxidase inhibition, molecular docking and dynamic simulations of novel 2,1-benzothiazine-2,2-dioxide derivatives

Bioorganic Chemistry, 2018
In this research work, we report the synthesis and biological evaluation of two new series of 1-benzyl-4-(benzylidenehydrazono)-3,4-dihydro-1H-benzo[c] [1,2]thiazine 2,2-dioxides and 1-benzyl-4-((1-phenylethylidene)hydrazono)-3,4-dihydro-1H-benzo[c][1,2]thiazine 2,2-dioxides.
Shakeel, Ahmad, Sumera, Zaib, Saquib, Jalil, Muhammad, Shafiq, Matloob, Ahmad, Sadia, Sultan, Mazhar, Iqbal, Sana, Aslam, Jamshed, Iqbal   +8 more
openaire   +2 more sources

Enantioselective synthesis of C3-functionalized 2,1-benzothiazine 2,2-dioxides by N-heterocyclic carbene catalysis

Chemical Communications
The direct and highly enantioselective C3-functionalization of the 2,1-benzothiazine 2,2-dioxide skeleton using NHC-catalyzed generation of chiral α,β-unsaturated acylazoliums, showcasing a synthesis pathway with enhanced pharmacological potential.
Karina Mroczyńska, Liliana Dobrzańska, Zbigniew Rafiński   +2 more
openaire   +2 more sources

Studies of 2,1-benzothiazine, silver-catalyzed rearrangement and 1,5-hydride shift

2018
Title from PDF of title page (University of Missouri--Columbia, viewed on Feb 26, 2010). ; The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. ; Thesis advisor: Dr. Michael Harmata. ; Vita. ; Ph.D.
openaire   +2 more sources

Study of the chemistry of 2,1-benzothiazines and toward the total synthesis of elisapterosin B

2018
Vita. ; Title from PDF of title page (University of Missouri--Columbia, viewed on March 1, 2010). ; The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. ; Dissertation advisor: Dr. Michael Harmata. ; Ph.D. University of Missouri--
openaire   +2 more sources

In-silico modeling and in-vitro studies of 2,1-benzothiazine-2,2-dioxide based hydrazone derivatives as α-glucosidase inhibitors.

Pakistan journal of pharmaceutical sciences, 2022
Diabetes mellitus (DM) is a metabolic disorder characterized by frequent urination, hunger and high blood sugar level. α-glucosidase inhibitors are considered as a frontline treatment for the DM. This research article deals with the identification of benzothiazine derivatives as α-glucosidase inhibitors through in-silico techniques and then the ...
Shakeel, Ahmad, Saman, Taj, Sana, Aslam, Samreen, Gul Khan, Tahir, Farooq, Usman Ali, Ashfaq, Matloob, Ahmad   +6 more
openaire   +1 more source

Facile Preparation of 3,4-Dihydro-2,1-benzothiazine 2,2-Dioxides and Related Reaction with 1,3-Diiodo-5,5-dimethylhydantoin under Photochemical Conditions

Synlett, 2009
3,4-Dihydro-2,1-benzothiazine 2,2-dioxides were easily obtained in good yields by the reaction of N-methyl 2-arylethane-sulfonamides with 1,3-diiodo-5,5-dimethylhydantoin (D1H) under irradiation with a tungsten lamp. When N-benzyl 2-phenylethane-sulfonamide was treated with DIH under the same conditions, the corresponding N-benzyl 3,4-dihydro-2,1 ...
Hideo Togo, Atsushi Moroda, Shusuke Furuyama   +2 more
openaire   +1 more source