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2-Aminopyridine – an unsung hero in drug discovery

Chemical Communications, 2022
2-Aminopyridine is a simple, low molecular weight and perfectly functionalised moiety known for the synthesis of diverse biological molecules.
Ramdas Nishanth Rao, Kaushik Chanda
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Solvent-free synthesis of novel steroidal 2-aminopyridines

Steroids, 2016
The synthesis of novel steroidal 3-cyano-2-aminopyridines using enaminonitrile and various primary amines was established under solvent-free condition. Structures of the new compounds were characterized by MS, 1H and 13C NMR data and the structure of 2-aminopyridine of the product 5b was further confirmed by X-ray analysis.
Yan-Ling, Zhang   +5 more
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Thermochemistry of 2-Aminopyridine (C5H6N2)(s)

Journal of Solution Chemistry, 2011
The molar enthalpies of solution of 2-aminopyridine at various molalities were measured at T = 298.15 K in double-distilled water by means of an isoperibol solution- reaction calorimeter. According to Pitzer's theory, the molar enthalpy of solution of the title compound at infinite dilution was calculated to besolH ∞ m = 14.34 kJ · mol −1 , and Pitzer ...
Dong-Hua He   +3 more
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Phosphorus-Nitrogen Compounds IV. Some 2-Aminopyridine Derivatives

Journal of Pharmaceutical Sciences, 1965
Seventeen phosphoramidates and phosphoramidothionates containing 2-aminopyridine moieties were synthesized as potential antineoplastic agents.
L A, CATES, N M, FERGUSON
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Bis(μ-2-aminopyridine)bis[(trifluoroacetato)silver(I)]

Acta Crystallographica Section C Crystal Structure Communications, 2004
The title compound, [Ag2(C2F3O2)2(C5H6N2)2], is a dinuclear AgI complex with inversion symmetry. Each Ag atom is three-coordinated by two N atoms from two different 2-aminopyridine ligands and by one O atom from a trifluoroacetate anion, giving an approximately trigonal coordination environment.
Zhong Lu, You, Hai Liang, Zhu
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Remote protection prevents unwanted cyclizations with 2-aminopyridines

Tetrahedron Letters, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Graham R. Lawton   +2 more
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Electrophilic benzylation of 2‐aminopyridine ring

Journal of Heterocyclic Chemistry, 1991
AbstractIn the reaction of 2‐aminopyridine and its 3‐ or 5‐methyl derivatives with benzyl chloride used in a molar ratio of 1:2, benzylation of 2‐aminopyridine ring has been stated that 2‐amino‐3‐ or 5‐benzylpyridines c as the major products were obtained.
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2‐Aminopyridine derivatives as potential chiral auxiliaries

Journal of Heterocyclic Chemistry, 1995
Abstract2‐Bromopyridine and 2‐bromo‐6‐methoxymethylpyridine reacted with an excess of 1‐phenylethylamine at reflux giving the aminopyridine derivatives 3a and 3b respectively.
Julie A. Parker, S. P. Stanforth
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Reactions of 2‐aminopyridine with picryl halides

Journal of Heterocyclic Chemistry, 1976
Abstract2‐Aminopyridine reacts with picryl halides to give mixtures of 1‐picryl‐2‐(N‐picrylimino)‐1,2‐dihydropyridine and 2‐(N‐picrylamino)pyridine. When picryl fluoride is treated with an excess of 2‐aminopyridine, the 1‐picryl‐2‐(N‐picrylimino)‐1,2‐dihydropyridine reacts further with 2‐aminopyridine to yield two molecules of 2‐(N‐picrylamino)pyridine
Betty W. Harris   +2 more
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ChemInform Abstract: SELECTIVE FORMYLATION OF 2‐AMINOPYRIDINES

Chemischer Informationsdienst, 1974
AbstractEntsprechend dem Formelschema werden die Aminopyridine (I) in die Formylderivate (IV) übergeführt, die auch über die Thiomethyläther (V) zugänglich sind.
P. G. GASSMAN, C. T. HUANG
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