6-Benzyl-3,4-dimethoxy-10-methylpyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-one
Acta Crystallographica Section E, 2009 Pyrido[2′,1′:2,3]imidazo[4,5-c]isoquinolin-5(6H)-ones such as the title compound, C24H21N3O3, can be obtained in a few minutes in a microwave-assisted three-component reaction from 2-aminopyridines, isocyanides and 2 ...
Kathrin Meindl +3 more
doaj +1 more source
Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions [PDF]
, 2016 A novel, rapid and efficient route to imidazo[1,2-a]pyridines under ambient, aqueous and metal-free conditions is reported. The NaOH-promoted cycloisomerisations of N-propargylpyridiniums give quantitative yield in a few minutes (10 g scale).
A. John Blacker +54 more
core +1 more source
Pyridinium N-heteroarylaminides: synthesis of N-heteroaryltetramines based on 1,6-bis(phenoxy)hexane and 1,3-bis(phenoxymethyl)benzene [PDF]
, 2007 The synthesis of a set of new N-heteroaryltetramines is reported. A regioselective alkylation on the N-exo nitrogen of pyridinium N-(heteroaryl)aminide with the corresponding tetrabromo compounds, followed by a clean N–N bond reduction of the ...
Castillo Romero, Rafael +2 more
core +2 more sources
Regiodivergent C3 and C4 Amination of Quinolines via Radical and Ionic Pathways
Angewandte Chemie, EarlyView.A regiodivergent strategy converts a single N‐aminoquinolinium precursor into either C3‐ or C4‐aminated quinolines. Nucleophile‐induced dearomatization diverges into light‐driven N‐centered radical capture (C3) or base‐promoted SNAr (C4), enabling rapid assembly of aminoquinoline libraries and late‐stage diversification.
Ye‐Eun Kim +3 more
wiley +2 more sources
Pyridinium N-2´-pyridylaminide: synthesis of 3-aryl-2-aminopyridines through an intramolecular radical process [PDF]
, 2004 Tris(trimethylsilyl)silane (TTMSS) and azobisisobutironitrile (AIBN) promote the intramolecular heteroarylation of arenesulfonamides with pyridyl radicals under thermal conditions.
Burgos García, Carolina +3 more
core +3 more sources
Study on a three-step rapid assembly of zolpidem and its fluorinated analogues employing microwave-assisted chemistry [PDF]
, 2020 We developed an efficient microwave-assisted three-step synthesis of zolpidem and its fluorinated analogues 1–3. The procedure relays on the utilization of easily accessible and inexpensive starting materials.
Fajkis, Nikola +4 more
core +1 more source
Structure property relationships in halogenated aromatic amides and imides [PDF]
, 2017 The effect of halogens (X) and pyridine N atom substitution patterns on molecular structure and conformation is analyzed and discussed herein. Several series of 3 x 3 isomer grids (Scheme 1; Figs 1-3) of halo-N-(pyridyl)benzamides (Xxx) (C12H9N2OX, x ...
Aubert, E. +5 more
core +2 more sources
Heterocycle-based bifunctional organocatalysts in asymmetric synthesis [PDF]
, 2016 Different chiral bifunctional organocatalysts derived from trans-cyclohexane-1,2-diamine bearing different types of guanidine units able to form-hydrogen bonding activation have been designed. Conformational rigid 2-aminobenzimidazoles bearing a tertiary
Gómez Bengoa, Enrique +2 more
core +2 more sources
Scientia Pharmaceutica, 2019 According to our quantum and chemical calculations 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid imidazolide is theoretically almost as reactive as its 2-carbonyl analog, and it forms the corresponding N-pyridyl-4-methyl-2,2-dioxo-1H-2&
Igor V. Ukrainets +8 more
doaj +1 more source
Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei [PDF]
, 2013 African trypanosomes are sustained in the bloodstream of their mammalian hosts by their extreme capacity for antigenic variation. However, for life cycle progression, trypanosomes also must generate transmission stages called stumpy forms that are pre ...
Macgregor, Paula +5 more
core +2 more sources