Results 81 to 90 of about 4,204 (201)
ChemistryOpen, EarlyView.In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye +2 more
wiley +1 more source
Review: Current treatment of vestibular, ocular motor disorders and nystagmus
Therapeutic Advances in Neurological Disorders, 2009 Vertigo and dizziness are among the most common complaints with a lifetime prevalence of about 30%. The various forms of vestibular disorders can be treated with pharmacological therapy, physical therapy, psychotherapeutic measures or, rarely, surgery ...
Michael Strupp, Thomas Brandt
doaj +1 more source
Nitric Oxide Synthase Inhibitors [PDF]
, 2017 Nitric oxide (NO) is an endogenic product from plants, bacteria, and animal cells that has many important effects in those organisms. It is produced by nitric oxide synthase (NOS), which is found in main three isoforms, namely endothelial NOS (eNOS ...
Ferreira, Elizabeth Igne +1 more
core +2 more sources
Opening closed inward rectifier potassium channel doors
British Journal of Pharmacology, EarlyView.Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger +3 more
wiley +1 more source
Spreading depolarization and its influence on epileptiform activity
Epilepsia, EarlyView.Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque +2 more
wiley +1 more source
Synthesis and antioxidant evaluation of some new pyridines [PDF]
, 2015 One-pot condensation of malononitrile (1), 4-methylpentan-2-one (2), aryl carboxaldehyde (3a-f) and ammonium acetate in ethanol afforded 2-amino-5-isopropyl-4-(4-aryl)-6-methylnicotinonitriles (4a-f).
Gouda, Moustafa Ahmed +1 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Blebbistatin reduces Ca2+ buffering in induced pluripotent stem cell‐derived atrial cardiomyocytes. Blebbistatin, a widely used excitation–contraction uncoupling agent, decreases calcium (Ca2+) buffer affinity (increased buffer dissociation constant), leading to elevated diastolic Ca2+ levels, increased sarcoplasmic reticulum Ca2+
Izzatullo Sobitov +8 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Our study demonstrates that both GABA and glycine mediate inhibitory postsynaptic currents in the ventrolateral/ventromedial medulla (VLM/VMM) and increasing the activity of inhibitory synapses facilitates glycine release. We found that presympathetic VLM/VMM neurons receive glycinergic inputs, which release both glycine and GABA,
Hong Gao +5 more
wiley +1 more source
Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes
The Journal of Physiology, EarlyView.Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve +11 more
wiley +1 more source
2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors. [PDF]
Bioorg Med Chem, 2022 Vasu D +4 more
europepmc +1 more source