Results 111 to 120 of about 96,981 (305)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Accelerated Super-Resolution Reconstruction for Structured Illumination Microscopy Integrated with Low-Light Optimization

Micromachines
Structured illumination microscopy (SIM) with π/2 phase-shift modulation traditionally relies on frequency-domain computation, which greatly limits processing efficiency. In addition, the illumination regime inherent in structured illumination techniques
Caihong Huang, Dingrong Yi, Lichun Zhou
doaj   +1 more source

Derivation cohort (ACE 2 study) flow chart.

, 2016
Derivation cohort (ACE 2 study) flow chart.
Helge Røsjø (162126), Torbjørn Omland (162193), Pål H. Brekke (2967489), Tor-Arne Hagve (2585494), Jon Brynildsen (2585503), Arne Didrik Høiseth (2585500), Jacob A. Winther (2967492), Ivar Følling (2967486), Geir Christensen (162197), Joseph G. Verbalis (499398)   +9 more
core   +1 more source

Inner Derivations and Weak-2-Local Derivations on the C*-Algebra C-0(L, A) [PDF]

, 2017
[EN] Let L be a locally compact Hausdorff space. Suppose A is a -algebra with the property that every weak-2-local derivation on A is a (linear) derivation. We prove that every weak-2-local derivation on is a (linear) derivation.
Jorda Mora, Enrique, Peralta, A.M.
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Existence of positive solutions for non local p-Laplacian thermistor problems on time scales

, 2007
We make use of the Guo-Krasnoselskii fixed point theorem on cones to prove existence of positive solutions to a non local p-Laplacian boundary value problem on time scales arising in many applications. © 2007 Victoria University.
Ammi, M.R.S., Torres, D.F.M.
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The MEST score provides earlier risk prediction in IgA nephropathy

, 2015
The Oxford Classification of IgA nephropathy (IgAN) includes the following four histologic components: mesangial (M) and endocapillary (E) hypercellularity, segmental sclerosis (S) and interstitial fibrosis/tubular atrophy (T).
Feehally, J, Barbour, Sj, Coppo, R, Espino-Hernandez, G, Roberts, Isd, Reich, Hn, Herzenberg, Am, Oxford Derivation North American Validation and VALIGA Consortia, Morosetti, M, Cattran, Dc   +9 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source