Results 131 to 140 of about 96,981 (305)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Derivations with conditions on polynomials
, 2008 出版單位:真理大學[[abstract]]Let R be a prime ring with extended centroid C and f(X1; : : : ;Xt) a nonzero polynomial over C. Suppose that d is a nonzero derivation of R such that h d(f(x1; : : : ; xt)); f(x1; : : : ; xt) i k = 0 (d(f(x1; : : : ; xt)) 2 C) for ...
張志銘, Chang,Chi-ming
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A stronger Bell argument for quantum non-locality [PDF]
, 2012 It is widely accepted that the violation of Bell inequalities excludes local theories of the quantum realm. In this paper I present a stronger Bell argument which even forbids certain non-local theories.
Näger, Paul M +2 more
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
2-Local derivations on matrix algebras and algebras of measurable operators
, 2017 12 ...
Ayupov, Shavkat +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Sensitivity Analysis of CO2 Emitted in Clinker and Cement Production
ComputationThis study performs a sensitivity analysis of CO2 emissions from clinker and cement production using life cycle assessment (LCA). Both local and global sensitivity analyses (LSA and GSA) are conducted. LSA uses outputs from the GCCA EPD tool—developed by
Dimitris Tsamatsoulis
doaj +1 more source
Local and 2-local $\frac{1}{2}$-derivations on finite-dimensional Lie algebras
In this work, we introduce the notion of local and $2$-local $\delta$-derivations and describe local and $2$-local $\frac{1}{2}$-derivation of finite-dimensional solvable Lie algebras with filiform, Heisenberg, and abelian nilradicals.
Yusupov, Bakhtiyor +1 more
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