Results 11 to 20 of about 42,888,361 (250)
Recent advances in chemistry and pharmacological aspects of 2-pyridone scaffolds
Journal of Saudi Chemical Society, 2021 Background: The chemistry and applications of 2-pyridone structures have recently attracted a lot of attention due to their uses as synthetic intermediates and their biological importance.
Mostafa M.K. Amer +4 more
doaj +2 more sources
Solid-Phase Synthesis of Diverse Macrocycles by Regiospecific 2‑Pyridone Formation: Scope and Applications [PDF]
JACS AuThis study introduces a novel solid-phase macrocyclization method generating 2-pyridone rings. This method relies on the intramolecular condensation between secondary and tertiary dimethoxy-propionic amide (DMPA) units.
Skander A. Abboud, Thomas Kodadek
doaj +3 more sources
Synthesis of New Aza-Heterocyclic Based on 2-Pyridone
Chemistry ProceedingsIn this work, we present new methods of synthesis of different molecules including a 2-pyridone nucleus. First, we prepared a series of 1H-free 2-pyridones and N-alkyl 2-pyridones from ethyl cyanoacetate, aromatic aldehydes, various acetophenone ...
Ikram Baba-Ahmed +4 more
doaj +2 more sources
catena-Poly[[[(2-pyridone-κO)silver(I)]-μ-2-pyridone-κ2O:O] hexafluoridophosphate]
Acta Crystallographica Section E, 2010 The asymmetric unit of the polymeric title salt, {[Ag(C5H5NO)2]PF6}n, comprises an AgI cation (located on a twofold axis), two 2-pyridone ligands (with distinct coordination modes), and half a PF6− anion (situated on a centre of inversion). The
Edward R. T. Tiekink +2 more
doaj +2 more sources
Bioactive 2-pyridone-containing heterocycle syntheses using multicomponent reactions. [PDF]
RSC Adv, 2022 2-Pyridone-containing heterocycles are considered privileged scaffolds in drug discovery due to their behavior as hydrogen bond donors and/or acceptors and nonpeptidic mimics, and remarkable physicochemical properties such as metabolic stability ...
Hurtado-Rodríguez D +4 more
europepmc +2 more sources
, 2016 Novel highly emissive 2-pyridone-based compounds 3a,b and 4a–d were synthesized by a convenient one-pot method from 4-(dialkylamino)acetophenones (1a,b) and cyanoketene dithioacetal (2a) or sulfonyl ketene dithioacetals (2b,c), and their fluorescence ...
Wang, Bo-cheng; Tai, Chen-kuen; Wang, San-lang; Shih, Tzenge-lien; Wu, Kuen-da; Huang, Zhi-shuan; Tseng, Shih-chuw; Lu, Jian-wei; Wei, Ho-hsiang
core +2 more sources
Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β Fibrils. [PDF]
J Org Chem, 2020 A BF3·OEt2 catalyzed intramolecular Povarov reaction was used to synthesize 15 chromenopyridine fused thiazolino-2-pyridone peptidomimetics. The reaction works with several O-alkylated salicylaldehydes and amino functionalized thiazolino-2-pyridones, to ...
Adolfsson DE +10 more
europepmc +2 more sources
Iron-Catalyzed Regioselective Direct Arylation at the C-3 Position of N-Alky1-2-pyridone
Journal of Organic Chemistry, 2015 A number of pharmaceutical compounds possess an arylated 2-pyridone moiety. The existing reports using expensive starting materials and/or superstoichiometric metal salts have prompted us to explore a possible user-friendly method for their synthesis. In
MAITI, D, MODAK, A, RANA, S
core +2 more sources
Six Years (2012-2018) of Researches on Catalytic EZH2 Inhibitors: The Boom of the 2-Pyridone Compounds. [PDF]
Chem Rec, 2018 Enhancer of zeste homolog 2 (EZH2), the catalytic subunit of the Polycomb repressive complex 2 (PRC2), catalyzes the methylation of lysine 27 of histone H3 (H3K27) up to its trimethylated form (H3K27me), inducing by this way block of transcription and ...
Fioravanti R +4 more
europepmc +2 more sources
Organic Letters, 2022 A chemical investigation of the filamentous fungus Aspergillus californicus led to the isolation of a polyketide-nonribosomal peptide hybrid, calipyridone A (1).
Yaojie Guo +7 more
semanticscholar +1 more source