Solid-Phase Synthesis of Diverse Macrocycles by Regiospecific 2‑Pyridone Formation: Scope and Applications [PDF]
JACS AuThis study introduces a novel solid-phase macrocyclization method generating 2-pyridone rings. This method relies on the intramolecular condensation between secondary and tertiary dimethoxy-propionic amide (DMPA) units.
Skander A. Abboud, Thomas Kodadek
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Microwave assisted synthesis of 2-pyridone and 2-pyridone based compounds [PDF]
Hemijska Industrija, 2014 2-Pyridones are important heterocyclic compounds that are widely used in medical chemistry, and their various derivatives have significant biological and medical applications.
Mijin Dušan Ž. +3 more
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catena-Poly[[[(2-pyridone-κO)silver(I)]-μ-2-pyridone-κ2O:O] hexafluoridophosphate]
Acta Crystallographica Section E, 2010 The asymmetric unit of the polymeric title salt, {[Ag(C5H5NO)2]PF6}n, comprises an AgI cation (located on a twofold axis), two 2-pyridone ligands (with distinct coordination modes), and half a PF6− anion (situated on a centre of inversion). The
Edward R. T. Tiekink +2 more
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Synthesis of New Aza-Heterocyclic Based on 2-Pyridone
Chemistry ProceedingsIn this work, we present new methods of synthesis of different molecules including a 2-pyridone nucleus. First, we prepared a series of 1H-free 2-pyridones and N-alkyl 2-pyridones from ethyl cyanoacetate, aromatic aldehydes, various acetophenone ...
Ikram Baba-Ahmed +4 more
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Palladium-Catalyzed β-C(sp3)–H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands [PDF]
Molecules2-Pyridone ligand-facilitated palladium-catalyzed direct C–H bond functionalization via the transient directing group strategy has become an attractive topic.
Ziting Xu +4 more
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2-Pyridone: monoclinic polymorph
Acta Crystallographica Section E, 2009 The asymmetric unit in the title compound, C5H5NO, comprises two independent but virtually identical molecules of 2-pyridone, and represents a monoclinic polymorph of the previously reported orthorhombic (P212121) form [Penfold (1953). Acta Cryst. 6, 591&
Edward R. T. Tiekink +2 more
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Bis(μ-1,4-dihydropyridin-4-one-κ2O:O)di-μ-perchlorato-κ4O:O′-bis[aqua(1,4-dihydropyridin-4-one-κO)copper(II)] tetraaquabis(1,4-dihydropyridin-4-one-κO)copper(II) tetrakis(perchlorate) 1,4-dihydropyridin-4-one disolvate [PDF]
IUCrDataThe reaction of copper(II) perchlorate hexahydrate with 4-pyridone and pyrazine in 1-propanol serendipitously yielded crystals of the solvated title double salt, [Cu(C5H5NO)2(H2O)4][Cu2(ClO4)2(C5H5NO)4(H2O)2](ClO4)4·2C5H5NO, as a biproduct.
Mark M. Turnbull +2 more
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New thiazole, thiophene and 2-pyridone compounds incorporating dimethylaniline moiety: synthesis, cytotoxicity, ADME and molecular docking studies [PDF]
BMC ChemistryVarious sets of thiazole, thiophene, and 2-pyridone ring structures containing a dimethylaniline component were synthesized. Substituted thiazoles 2–3 and thiophenes 5–7 were produced by reacting thiocarbamoyl compound 4 with α-halogenated reagents in ...
Heba M. Metwally +3 more
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Pyridone alkaloids from an Antarctic endolichenic Tolypocladium sp. [PDF]
Natural Products and BioprospectingThree new pyridone alkaloids, tolypyrone A (1), tolypyrosides A (2) and B (3), and a new tetramic acid 2′-epitolypoalbin (4), along with ten known compounds, were obtained from Tolypocladium sp.
Shasha Li +7 more
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2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease [PDF]
Chemico-Biological Interactions, 2021 Ian Pottie, Meghan K Cash
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