Results 31 to 40 of about 42,888,361 (250)
Rhodium(I)-Complexes Catalyzed 1,4-Conjugate Addition of Arylzinc Chlorides to N-Boc-4-pyridone
Molecules, 2017 Rhodium(I)-complexes catalyzed the 1,4-conjugate addition of arylzinc chlorides to N-Boc-4-pyridone in the presence of chlorotrimethylsilane (TMSCl). A combination of [RhCl(C2H4)2]2 and BINAP was determined to be the most effective catalyst to promote ...
Fenghai Guo +5 more
doaj +1 more source
New Pyridone-Based Derivatives as Cannabinoid Receptor Type 2 Agonists [PDF]
, 2021 The activation of the human cannabinoid receptor type II (CB2R) is known to mediate analgesic and anti-inflammatory processes without the central adverse effects related to cannabinoid receptor type I (CB1R).
Faundez Parraguez, Manuel +16 more
core +1 more source
Angewandte Chemie, EarlyView.Leigh's metal‐free active template‐based SNAr of an amine on halogenopyridiniums, in the presence of a crown ether, successfully afforded 4‐aminopyridinium‐containing rotaxanes. Further molecular machinery was carried out by deprotonation‐then‐carbamoylation of the conjugated amino moiety.
Ivaylo Stoyanov +2 more
wiley +2 more sources
SYNTHESIS AND ANTIHYPERLIPIDEMIC ACTIVITY OF CERTAIN NICOTINIC ACID DERIVATIVES [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2005 3-Ethoxycarbonyl-4,6-dimethyl-2(1H)-pyridone I was prepared and converted to the corresponding sodium salt II. The latter reacted with certain chloroacetanilides to afford the corresponding ethers III.
Mohamed Abdel-Wahab +1 more
doaj +1 more source
Ribonucleotide reductase, a novel drug target for gonorrhea
eLife, 2022 Antibiotic-resistant Neisseria gonorrhoeae (Ng) are an emerging public health threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two novel orally active inhibitors, PTC-847 and PTC-672, that exhibit a narrow spectrum ...
Jana Narasimhan +15 more
doaj +1 more source
Dyes and pigments, 2020 A series of nine 5-(4-substituted phenylazo)-3-amido-6-hydroxy-4-methyl-2-pyridones were synthesized and characterized by FT–IR, 1H and 13C NMR, UV–Vis, and PL spectroscopy.
Slavica Porobic +6 more
semanticscholar +1 more source
Biosynthesis of (–)-Sambutoxin, a Fusarium 2-Pyridone Alkaloid Mycotoxin [PDF]
, 2021 This dissertation describes the discovery by genome mining and the characterization of thebiosynthetic pathway for sambutoxin, a 4-hydroxy-2-pyridone alkaloid Fusarium mycotoxin.
Go, Louise
core
, 2022 A family of anionic, formally nickel(0) complexes supported by bidentate NHC–pyridone ligands is described. The unsymmetric chelating environment and capping [K(18-crown-6)]+ countercation allow isolation of single-component, monometallic complexes in ...
C. Rose, Kennedy +4 more
core +1 more source
Molecular Pharmaceutics, 2018 Sambutoxin, a representative derivative of 4-hydroxy-2-pyridone, was isolated from Hericium alpestre for the first time in this study. The possible correlation between the sambutoxin-induced suppression of tumor growth and its influence on cell-cycle ...
Lu Li +5 more
semanticscholar +1 more source
mBio, 2021 Diverse 2-pyridone alkaloids have been identified with an array of biological and pharmaceutical activities, including the development of drugs. However, the biosynthetic regulation and chemical ecology of 2-pyridones remain largely elusive.
Bo Chen +4 more
doaj +1 more source