Results 31 to 40 of about 6,535 (185)

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

Two Pyrones with Antibacterial Activities from

Natural Product Communications, 2016
A new pyrone derivative, malakavalactone ( 2 ), was isolated from the acetone extract of Alpinia malaccensis fruits, along with a known compound kavalactone ( 1 ).
Tita Juwitaningsih, Lia D Juliawaty, Yana M. Syah   +2 more
doaj   +1 more source

Free Phenolic Hydroxyl Groups Govern the Anticancer Activity of α‐Mangostin: A Structure–Activity Relationship Insight

ChemFoodChem, EarlyView.
Free phenolic hydroxyl groups in the chemical structure of the natural xanthone α‐mangostin (MGT) contribute positively to achieving the anticancer profile against murine colon cancer, murine triple negative breast cancer, and human osteosarcoma cancer. ABSTRACT The α‐mangostin (MGT) is a natural xanthone obtained from the pericarp of mangosteen fruit (
Otávio Augusto Chaves, Afonso Santine M. M. Velez, Lívia Stenico, Douglas Chaves de Alcântara Pinto, Debora Decote‐Ricardo, Eliezer Avila Gandra, Marco Edilson Freire de Lima, Carlos Serpa   +7 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Caffeylpyruvate hydrolase from the bioluminescent fungus Neonothopanus gardneri is the key recycling enzyme in the fungal bioluminescence pathway

The FEBS Journal, EarlyView.
Caffeic acid is a central metabolite in the fungal bioluminescence pathway. We identified and characterized caffeylpyruvate hydrolase from Neonothopanus gardneri (ngarCPH) and demonstrate its ability to hydrolyze fungal oxyluciferin into caffeic and pyruvic acids, confirming a complete and self‐sustained fungal bioluminescence cycle.
Caio K. Zamuner, Douglas M. M. Soares, Bianca B. Nóbrega, Etelvino J. H. Bechara, Zinaida M. Kaskova, Alexander S. Mishin, Karen S. Sarkisyan, Ilia V. Yampolsky, Cassius V. Stevani   +8 more
wiley   +1 more source

Isotelluroureas for Asymmetric C1 Ammonium Enolate Reactions

European Journal of Organic Chemistry, Volume 29, Issue 31, 19 August 2026.
Chiral isotelluroureas are powerful catalysts for a variety of C─C bond forming C1 ammonium enolate transformations. Isotelluroureas (ITeUs) have recently been introduced as a novel class of highly nucleophilic Lewis base catalysts. Herein, we systematically screened them for their potential to facilitate C1 ammonium enolate transformations and ...
Fereshteh Khorasani, Lotte Stockhammer, Magdalena Piringer, Mario Waser   +3 more
wiley   +1 more source

Preparation and assessment cytotoxic and hemolytic activities of Complexes from “Chelating Kojic–Lipid Conjugate”

Orbital: The Electronic Journal of Chemistry, 2012
Complex bis (2-Oleicoyloxymethyl-5-hydroxy-gamma-pyrone) copper (II) and tris (2-Oleicoyloxymethyl-5-hydroxy-gamma-pyrone) iron (III) were prepared in ethanol using the structure "chelator conjugate kojic -lipid".
Antônio S. C. Carvalho, Raquel C. Montenegro, Alberdan S. Santos   +2 more
doaj   +1 more source

Reimagining Lignin Valorization: Synthetic Biology–Enabled Sustainable Aromatic Carbon Biomanufacturing

Advanced Science, Volume 13, Issue 47, 24 August 2026.
The diagram illustrates a sustainable model of lignin valorization and carbon cycling based on microbial cell factories. Using lignin as the feedstock, synthetic biology technologies, including depolymerization, cell factory construction, pathway gene module integration, and metabolic network regulation, are applied to convert lignin into bulk ...
Na Li, Jun‐Jie Zhangyang, Bing‐Zhi Li, Zhi‐Hua Liu, Ying‐Jin Yuan   +4 more
wiley   +1 more source

Ethnopharmacological Evaluation of a Wild Ecotype of Syzygium cumini (L.) Skeels (Jamoya) Fruit

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
The phytochemical and biological activity of Syzygium cumini (ecotype) fruit pulp and seed extracts using GC‐MS, UHPLC‐QTOF‐MS, and antidiabetic potential. ABSTRACT The wild ecotype of Jamun (Syzygium cumini) is known for its inedible fruits that are not yet explored for their bioactive potential. The present study assesses the ethnopharmacological and
Ritu Sharma, Umesh Pal, Jay Krishna Singh, Meenakshi Tanwar, Rajinder K. Gupta   +4 more
wiley   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source