Results 41 to 50 of about 2,659 (180)

Bioactive α-Pyrone Derivatives from the Endophytic Fungus Diaporthe sp. CB10100 as Inducible Nitric Oxide Synthase Inhibitors

Frontiers in Chemistry, 2021
Inducible nitric oxide synthase (iNOS) produces NO from l-arginine and plays critical roles in inflammation and immune activation. Selective and potent iNOS inhibitors may be potentially used in many indications, such as rheumatoid arthritis, pain, and ...
Hong Pu, Hong Pu, Hong Pu, Jianxin Liu, Yeji Wang, Yuhui Peng, Wanying Zheng, Yang Tang, Boping Hui, Chunmei Nie, Xueshuang Huang, Yanwen Duan, Yanwen Duan, Yanwen Duan, Yong Huang, Yong Huang   +15 more
doaj   +1 more source

Ethnopharmacological Evaluation of a Wild Ecotype of Syzygium cumini (L.) Skeels (Jamoya) Fruit

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
The phytochemical and biological activity of Syzygium cumini (ecotype) fruit pulp and seed extracts using GC‐MS, UHPLC‐QTOF‐MS, and antidiabetic potential. ABSTRACT The wild ecotype of Jamun (Syzygium cumini) is known for its inedible fruits that are not yet explored for their bioactive potential. The present study assesses the ethnopharmacological and
Ritu Sharma, Umesh Pal, Jay Krishna Singh, Meenakshi Tanwar, Rajinder K. Gupta   +4 more
wiley   +1 more source

Benzyl Furanones and Pyrones from the Marine-Derived Fungus Aspergillus terreus Induced by Chemical Epigenetic Modification

Molecules, 2020
Chemical epigenetic modification on a marine-derived fungus Aspergillus terreus RA2905 using a histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), resulted in a significantly changed metabolic profile.
Jing-Shuai Wu, Xiao-Hui Shi, Ya-Hui Zhang, Chang-Lun Shao, Xiu-Mei Fu, Xin Li, Guang-Shan Yao, Chang-Yun Wang   +7 more
doaj   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored

Biomolecules, 2022
Aspergillus unguis belongs to the Aspergillus section Nidulantes. This species is found in soils and organisms from marine environments, such as jellyfishes and sponges. The first chemical study reported in the literature dates from 1970, with depsidones
Levy Tenório Sousa Domingos, Raquel dos Santos Martins, Leonardo Melo de Lima, Angela Michelato Ghizelini, Antonio Ferreira-Pereira, Fernando Cotinguiba   +5 more
doaj   +1 more source

Experimental, Genomic, and Structural Evidence Supporting Putative PET‐Hydrolases in Thermophilic Bacteria Isolated From Hot Springs in Cajamarca, Peru

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Integrated microbiological, genomic, and structural analyses of bacteria isolated from a Peruvian geothermal system reveal enzymatic potential for the transformation of polyesters such as PET. This study links experimental evidence with genomic determinants and in silico analyses that support the thermophilic bacteria biodegradation capacity.
Marco A. Rivera‐Jacinto, Claudia Rodríguez‐Ulloa, Sara R. Briones‐Ramírez, Betsy Quispe‐Cruz, Sandra Carrasco‐Tarrillo, Diego A. Leonardo, Juan P. Cardenas   +6 more
wiley   +1 more source

(2‐Phosphinophenyl)aluminum Dichloride Complexes as Intramolecular Al/P Frustrated Lewis Pairs for Ketone, Ester, and Imine Activation

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
Three 2‐phosphinophenylaluminum dichloride complexes were synthesized and characterized as novel intramolecular FLPs. These FLP systems exhibit high Lewis acidity and effectively activate challenging substrates including aliphatic ketones, imines, and esters. DFT analysis revealed that strain release and Al–P dynamics govern their reactivity. Abstract (
Yoshihiro Nishimoto, Hirotaka Okamoto, Makoto Yasuda   +2 more
wiley   +1 more source

Dissection and Engineering of Modular Polyketide Synthase Extender Unit Specificity Motifs

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Motif‐level engineering of acyltransferase domains in polyketide synthases enables programable extender unit selectivity. Cooperative mutations and motif exchanges reprogram substrate preference, enabling the incorporation of non‐native extender units and expanding polyketide structural diversity, with gains in activity and product yield.
Sydney Welch, Gavin J. Williams
wiley   +1 more source

Mesityl‐Substituted Azuleno[1′,2′:4,5]pyrrolo[2,3‐b]quinoxalines: Synthesis, Functionalization, Photophysical, and Electrochemical Properties

European Journal of Organic Chemistry, Volume 29, Issue 26, 13 July 2026.
Azuleno[1′,2′:4,5]pyrrolo[2,3‐b]quinoxaline with a mesityl group as a solubilizing group was synthesized. By synthesizing derivatives in which various functional groups were introduced into two electronically distinct sites, the pyrrole nitrogen atom and the azulene five‐membered ring, we were able to reveal that the photophysical and electrochemical ...
Ryuta Sekiguchi, Hiroki Mizuno, Ikumi Uchiyama, Souta Yuruka, Atsuya Shimizu, Taku Shoji, Shunji Ito   +6 more
wiley   +1 more source

A 3-Vinyl Cephem Derivative, a Useful Intermediate in the Synthesis of Cepham Antibiotics, from Associated with Banana Fruit

Natural Product Communications, 2015
Aspergillus awamori was isolated from a diseased banana fruit, Musa acuminata cv. Ambul. The fungus was fermented in potato dextrose broth and on potato dextrose agar media and the fungal media were extracted with EtOAc. Chromatographic separation of the
H.M.S.K.H Bandara, N. Savitri Kumar, Lalith Jayasinghe, Hironori Masubuti, Yoshinori Fujimoto   +4 more
doaj   +1 more source