Synergistic Antibacterial Potential of 6-Pentyl-α-pyrone Lactone and Zinc Oxide Nanoparticles against Multidrug-Resistant Enterobacterales Isolated from Urinary Tract Infections in Humans [PDF]
Antibiotics, 2022 Urinary tract infection (UTI) is one of the most common bacterial infections in the world, which is associated with high morbidity and mortality rates.
Ahmed M. E. Kotb +5 more
doaj +2 more sources
Assessment on facile Diels–Alder approach of α-pyrone and terpenoquinone for the expedient synthesis of various natural scaffolds [PDF]
Natural Products and Bioprospecting, 2022 The development of highly facile synthetic procedures for the expedient synthesis of complex natural molecules is always in demand. As this aspect, the Diels–Alder reaction (DAR) has a versatile approach to the synthesis of complex natural compounds and ...
Aluru Rammohan +5 more
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Nocapyrones: α- and γ-Pyrones from a Marine-Derived Nocardiopsis sp. [PDF]
Marine Drugs, 2014 One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2–4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment.
Youngju Kim +7 more
doaj +3 more sources
Bioactive α-Pyrone Derivatives from the Endophytic Fungus Diaporthe sp. CB10100 as Inducible Nitric Oxide Synthase Inhibitors [PDF]
Frontiers in Chemistry, 2021 Inducible nitric oxide synthase (iNOS) produces NO from l-arginine and plays critical roles in inflammation and immune activation. Selective and potent iNOS inhibitors may be potentially used in many indications, such as rheumatoid arthritis, pain, and ...
Hong Pu +15 more
doaj +2 more sources
Bioactive α-Pyrone Analogs from the Endophytic Fungus Diaporthe sp. CB10100: α-Glucosidase Inhibitory Activity, Molecular Docking, and Molecular Dynamics Studies [PDF]
MoleculesTwo α-pyrone analogs were isolated from the endophytic fungus Diaporthe sp. CB10100, which is derived from the medicinal plant Sinomenium acutum. These analogs included a new compound, diaporpyrone F (3), and a known compound, diaporpyrone D (4).
Zhong Wang +9 more
doaj +2 more sources
Fungal metabolite 6-pentyl-α-pyrone reduces canine coronavirus infection [PDF]
HeliyonCanine coronavirus (CCoV) can produce a self-limited enteric disease in dogs but, because of notable biological plasticity of coronaviruses (CoVs), numerous mutations as well as recombination events happen leading to the emergence of variants often more ...
Claudia Cerracchio +6 more
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Rapid Discovery of Antifungal α-Pyrone Analogs from Diaporthe kyushuensis ZMU-48-1 via an HSQC-Based DeepSAT Strategy [PDF]
Journal of FungiEndophytic fungi represent an extensive source of chemically diverse and bioactive polyketides. Herein, an HSQC-based DeepSAT-guided strategy was employed for the scaffold-prioritized isolation of metabolites from Diaporthe kyushuensis ZMU-48-1, an ...
Siwen Yuan +6 more
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Electrochemical Corey–Winter reaction. Reduction of thiocarbonates in aqueous methanol media and application to the synthesis of a naturally occurring α-pyrone [PDF]
Beilstein Journal of Organic Chemistry, 2018 An electrochemical version of the Corey–Winter reaction was developed giving excellent results in aqueous methanol media (MeOH/H2O (80:20) with AcOH/AcONa buffer 0.5 M as supporting electrolyte), using a reticulated vitreous carbon as cathode in a ...
Ernesto Emmanuel López-López +3 more
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Eight new α-pyrone and γ-butenolide derivatives from the plant endophytic fungus Diaporthe sp. CCY4 [PDF]
Natural Products and BioprospectingFive new α-pyrones, diaporpyrones G-K (1–5) and three new γ-butenolide derivatives, porbutenolides A-C (6–8), along with seven known compounds (9–15), were isolated from the culture extract of the endophytic fungus Diaporthe sp. CCY4.
Jie-Chun Zeng +4 more
doaj +2 more sources
Chevalones H–M: Six New α-Pyrone Meroterpenoids from the Gorgonian Coral-Derived Fungus Aspergillus hiratsukae SCSIO 7S2001 [PDF]
Marine Drugs, 2022 Six new α-pyrone meroterpenoid chevalones H–M (1–6), together with six known compounds (7–12), were isolated from the gorgonian coral-derived fungus Aspergillus hiratsukae SCSIO 7S2001 collected from Mischief Reef in the South China Sea. Their structures,
Xia-Yu Chen +9 more
doaj +2 more sources