Results 31 to 40 of about 169 (88)

Emission solvatochromic, solid-state and aggregation-induced emissive α-pyrones and emission-tuneable 1H-pyridines by Michael addition–cyclocondensation sequences

Beilstein Journal of Organic Chemistry, 2019
Starting from substituted alkynones, α-pyrones and/or 1H-pyridines were generated in a Michael addition–cyclocondensation with ethyl cyanoacetate. The peculiar product formation depends on the reaction conditions as well as on the electronic substitution
Natascha Breuer, Irina Gruber, Christoph Janiak, Thomas J. J. Müller   +3 more
doaj   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Synthetic and Structure-Activity Relationship of Insecticidal Bufadienolides

Natural Product Communications, 2014
A new synthetic analog of bufadienolide, methyl isobryophyllinate A ( 1 ), and a known synthetic analog, methyl isobersaldegenate-1,3,5-orthoacetate ( 2 ), were obtained by methanolysis of bryophyllin A ( 3 ) and bersaldegenin-1,3,5-orthoacetate ( 5 ) in
Ace Tatang Hidayat, Achmad Zainuddin, Danar Dono, Wawan Hermawan, Hideo Hayashi, Unang Supratman   +5 more
doaj   +1 more source

Experimental, Genomic, and Structural Evidence Supporting Putative PET‐Hydrolases in Thermophilic Bacteria Isolated From Hot Springs in Cajamarca, Peru

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Integrated microbiological, genomic, and structural analyses of bacteria isolated from a Peruvian geothermal system reveal enzymatic potential for the transformation of polyesters such as PET. This study links experimental evidence with genomic determinants and in silico analyses that support the thermophilic bacteria biodegradation capacity.
Marco A. Rivera‐Jacinto, Claudia Rodríguez‐Ulloa, Sara R. Briones‐Ramírez, Betsy Quispe‐Cruz, Sandra Carrasco‐Tarrillo, Diego A. Leonardo, Juan P. Cardenas   +6 more
wiley   +1 more source

New Dibenzo-α-pyrone Derivatives with α-Glucosidase Inhibitory Activities from the Marine-Derived Fungus Alternaria alternata

Marine Drugs, 2022
Three new dibenzo-α-pyrone derivatives, alternolides A–C (1–3), and seven known congeners (4–10) were isolated from the marine-derived fungus of Alternaria alternata LW37 assisted by the one strain-many compounds (OSMAC) strategy.
Jinxin Zhang, Baodan Zhang, Lei Cai, Ling Liu   +3 more
doaj   +1 more source

(2‐Phosphinophenyl)aluminum Dichloride Complexes as Intramolecular Al/P Frustrated Lewis Pairs for Ketone, Ester, and Imine Activation

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
Three 2‐phosphinophenylaluminum dichloride complexes were synthesized and characterized as novel intramolecular FLPs. These FLP systems exhibit high Lewis acidity and effectively activate challenging substrates including aliphatic ketones, imines, and esters. DFT analysis revealed that strain release and Al–P dynamics govern their reactivity. Abstract (
Yoshihiro Nishimoto, Hirotaka Okamoto, Makoto Yasuda   +2 more
wiley   +1 more source

Effect of Culture Conditions on Metabolite Production of Xylaria sp.

Molecules, 2015
Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in the plant-associated fungus Xylaria sp., the effect of culture conditions on metabolite production was investigated.
Hongqi Zhang, Zhangshuang Deng, Zhiyong Guo, Yan Peng, Nianyu Huang, Haibo He, Xuan Tu, Kun Zou   +7 more
doaj   +1 more source

Chevalones H–M: Six New α-Pyrone Meroterpenoids from the Gorgonian Coral-Derived Fungus Aspergillus hiratsukae SCSIO 7S2001

Marine Drugs, 2022
Six new α-pyrone meroterpenoid chevalones H–M (1–6), together with six known compounds (7–12), were isolated from the gorgonian coral-derived fungus Aspergillus hiratsukae SCSIO 7S2001 collected from Mischief Reef in the South China Sea. Their structures,
Xia-Yu Chen, Qi Zeng, Yu-Chan Chen, Wei-Mao Zhong, Yao Xiang, Jun-Feng Wang, Xue-Feng Shi, Wei-Min Zhang, Si Zhang, Fa-Zuo Wang   +9 more
doaj   +1 more source

Mesityl‐Substituted Azuleno[1′,2′:4,5]pyrrolo[2,3‐b]quinoxalines: Synthesis, Functionalization, Photophysical, and Electrochemical Properties

European Journal of Organic Chemistry, Volume 29, Issue 26, 13 July 2026.
Azuleno[1′,2′:4,5]pyrrolo[2,3‐b]quinoxaline with a mesityl group as a solubilizing group was synthesized. By synthesizing derivatives in which various functional groups were introduced into two electronically distinct sites, the pyrrole nitrogen atom and the azulene five‐membered ring, we were able to reveal that the photophysical and electrochemical ...
Ryuta Sekiguchi, Hiroki Mizuno, Ikumi Uchiyama, Souta Yuruka, Atsuya Shimizu, Taku Shoji, Shunji Ito   +6 more
wiley   +1 more source

Fungal metabolite 6-pentyl-α-pyrone reduces canine coronavirus infection

Heliyon
Canine coronavirus (CCoV) can produce a self-limited enteric disease in dogs but, because of notable biological plasticity of coronaviruses (CoVs), numerous mutations as well as recombination events happen leading to the emergence of variants often more ...
Claudia Cerracchio, Luca Del Sorbo, Francesco Serra, Alessia Staropoli, Maria Grazia Amoroso, Francesco Vinale, Filomena Fiorito   +6 more
doaj   +1 more source