Results 1 to 10 of about 852 (122)
CRISPR-Cas9-Based Discovery of the Verrucosidin Biosynthesis Gene Cluster in Penicillium polonicum [PDF]
Frontiers in Microbiology, 2021 Penicillium polonicum, commonly found on food matrices, is a mycotoxigenic species able to produce a neurotoxin called verrucosidin. This methylated α-pyrone polyketide inhibits oxidative phosphorylation in mitochondria and thereby causes neurological ...
Silvia Valente +11 more
doaj +3 more sources
Natural Dibenzo-α-Pyrones and Their Bioactivities
Molecules, 2014 Natural dibenzo-α-pyrones are an important group of metabolites derived from fungi, mycobionts, plants and animal feces. They exhibit a variety of biological activities such as toxicity on human and animals, phytotoxicity as well as cytotoxic ...
Daowan Lai, Ligang Zhou
exaly +3 more sources
Beilstein Journal of Organic Chemistry, 2016 The α-pyrone moiety is a structural feature found in a huge variety of biologically active metabolites. In recent times new insights into additional biosynthetic mechanisms, yielding in such six-membered unsaturated ester ring residues have been obtained.
Till F Schäberle
exaly +2 more sources
Plants, 2023 This study aimed at the evaluation of the antioxidant and cognitive-enhancing effect of methanol–aqueous extract from Helichrysum italicum ssp. italicum aerial parts.
Reneta Gevrenova +6 more
doaj +1 more source
Divergent rhodium-catalyzed electrochemical vinylic C–H annulation of acrylamides with alkynes
Nature Communications, 2021 α-Pyridones and α-pyrones are ubiquitous structural motifs found in natural products and components of biologically active small molecules. Here, the authors report an oxidant-free Rh-catalyzed electrochemical divergent vinylic C–H annulation of ...
Yi-Kang Xing +6 more
doaj +1 more source
Bioactive Monoterpenes and Polyketides from the Ascidian-Derived Fungus Diaporthe sp. SYSU-MS4722
Marine Drugs, 2022 There has been a tremendous increase in the rate of new terpenoids from marine-derived fungi being discovered, while new monoterpenes were rarely isolated from marine-derived fungi in the past two decades. Three new monoterpenes, diaporterpenes A–C (1–3),
Guifa Zhai +5 more
doaj +1 more source
Marine Drugs, 2022 With the increasingly serious antimicrobial resistance, discovering novel antibiotics has grown impendency. The Antarctic abundant microbial resources, especially fungi, can produce unique bioactive compounds for adapting to the hostile environment.
Ting Shi +6 more
doaj +1 more source
Molecules, 2021 The fungal strain was isolated from a soil sample collected in Giza province, Egypt, and was identified as Aspergillus ochraceopetaliformis based on phenotypic and genotypic data.
Mostafa A. Asmaey +8 more
doaj +1 more source
ANALGESIC ACTIVITY OF SOME NEW SYNTHETIC DIBENZO-α-PYRONES DERIVATIVES
INTERNATIONAL JOURNAL OF RESEARCH IN AYURVEDA & PHARMACY, 2014 Following standard Hurtley reaction, by using 2 - Bromobenzoic acid, resorcinol and NaOH in the presence of CuSO 4 solution as a catalyst, a clay coloured solid of dibenzo - α - pyrone was prepared. This resulting solid of DBαP was then reacted with various amines respectively, formaldehyde and ethanol and refluxed for 1.5 h as per Mannich reaction ...
Shalini Sawhney +3 more
openaire +1 more source
Two new -Methoxy--Pyrones From the Mangrove Sediment-Derived SCSIO NS126
Natural Product Communications, 2021 Two new α -methoxy- γ -pyrone analogs, 2-methoxy-3-methyl-5,6-diethyl- γ -pyrone ( 2 ) and 2-methoxy-3,5-dimethyl-6-propyl- γ -pyrone ( 3 ), together with 2-methoxy-3,5-dimethyl-6-ethyl- γ -pyrone ( 1 ), firstly isolated from natural sources, were ...
Kunlong Li +6 more
doaj +1 more source