New Dibenzo-α-pyrone Derivatives with α-Glucosidase Inhibitory Activities from the Marine-Derived Fungus Alternaria alternata [PDF]
Marine Drugs, 2022 Three new dibenzo-α-pyrone derivatives, alternolides A–C (1–3), and seven known congeners (4–10) were isolated from the marine-derived fungus of Alternaria alternata LW37 assisted by the one strain-many compounds (OSMAC) strategy.
Jinxin Zhang +3 more
doaj +2 more sources
Potential Activity of 6-Pentyl-α-pyrone as an Antiviral for Bovine Coronavirus [PDF]
PathogensDuring infection in vitro with the strain 438/06 of bovine coronavirus (BCoV), a β-coronavirus similar to severe acute respiratory syndrome (SARS) CoV-2, treatment with 6-pentyl-α-pyrone (6PP), a fungal metabolite obtained from Trichoderma atroviride ...
Luca Del Sorbo +12 more
doaj +2 more sources
In Vitro Antiviral Activity of the Fungal Metabolite 6-Pentyl-α-Pyrone Against Bovine Coronavirus: A Translational Study to SARS-CoV-2 [PDF]
Veterinary SciencesThe recent COVID-19 pandemic has prompted the scientific community to prioritize the discovery of preventive methods and new therapeutics, including the investigation of natural compounds with antiviral potential.
Violetta Iris Vasinioti +14 more
doaj +2 more sources
Phloroglucinol α-Pyrones from Helichrysum: A Review on Structural Diversity, Plant Distribution and Isolation [PDF]
PlantsHelichrysum species (Asteraceae) are renowned for their diverse phytochemical profiles and traditional medicinal applications. Among their specialized metabolites, phloroglucinol-α-pyrone derivatives represent a structurally unique and pharmacologically ...
Yulian Voynikov
doaj +2 more sources
α-Pyrone Polyketides from Streptomyces ambofaciens BI0048, an Endophytic Actinobacterial Strain Isolated from the Red Alga Laurencia glandulifera [PDF]
Marine Drugs, 2017 Four new (1–4) and six previously reported (5–10) α-pyrone polyketides, along with benzoic acid, hydrocinnamic acid, and (E)-cinnamic acid, were isolated from the organic extract resulting from the cultivation of the algicolous strain Streptomyces ...
Enikő Rab +3 more
doaj +2 more sources
α-Pyrone Derivatives from a Streptomyces Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells [PDF]
Natural Products and Bioprospecting, 2017 Tamoxifen resistance (TamR) is the underlying cause of treatment failure in many breast cancer patients receiving tamoxifen. In order to look for noncytotoxic natural products with the ability to reverse TamR, an extract from strain Streptomyces sp.
Rui-Min Yang +8 more
doaj +2 more sources
Arzanol: A Review of Chemical Properties and Biological Activities [PDF]
PlantsArzanol, a prenylated phloroglucinol–α-pyrone heterodimer, displays a broad range of pharmacological properties. This review compiles findings from 2007 to 2025 on its chemistry, conformational behavior, bioactivities, molecular targets, and ...
Yulian Voynikov
doaj +2 more sources
Parafenestella varangrensis sp. nov., a phomenin producing fungus from the Arctic [PDF]
Scientific ReportsDriftwood-associated fungi are a less recognized source of secondary metabolites with diverse biological activities. The main aim of this study was to characterize a driftwood-associated Parafenestella (Pleosporales, Ascomycota) species and evaluate the ...
Sailesh Maharjan +6 more
doaj +2 more sources
Two new -Methoxy--Pyrones From the Mangrove Sediment-Derived SCSIO NS126
Natural Product Communications, 2021 Two new α -methoxy- γ -pyrone analogs, 2-methoxy-3-methyl-5,6-diethyl- γ -pyrone ( 2 ) and 2-methoxy-3,5-dimethyl-6-propyl- γ -pyrone ( 3 ), together with 2-methoxy-3,5-dimethyl-6-ethyl- γ -pyrone ( 1 ), firstly isolated from natural sources, were ...
Kunlong Li +6 more
doaj +1 more source
Bioinspired Synthesis of Twin abeo-Steroids Bufogargarizins A and B via a Divergent Intramolecular Aldol Addition Reaction. [PDF]
Angew Chem Int Ed EnglTwin natural products. This manuscript describes a concise biomimetic synthesis of twin abeo‐steroids bufogargarizins A and B with an unusual [7.5.6.5] and [5.7.6.5] skeletons in 19 steps (LLS). The described synthetic approach features the application of a bioinspired regiodivergent intramolecular aldol addition reaction and a selective singlet oxygen‐
Surma ZJ +7 more
europepmc +3 more sources