Potential Activity of 6-Pentyl-α-pyrone as an Antiviral for Bovine Coronavirus [PDF]
PathogensDuring infection in vitro with the strain 438/06 of bovine coronavirus (BCoV), a β-coronavirus similar to severe acute respiratory syndrome (SARS) CoV-2, treatment with 6-pentyl-α-pyrone (6PP), a fungal metabolite obtained from Trichoderma atroviride ...
Luca Del Sorbo +12 more
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In Vitro Antiviral Activity of the Fungal Metabolite 6-Pentyl-α-Pyrone Against Bovine Coronavirus: A Translational Study to SARS-CoV-2 [PDF]
Veterinary SciencesThe recent COVID-19 pandemic has prompted the scientific community to prioritize the discovery of preventive methods and new therapeutics, including the investigation of natural compounds with antiviral potential.
Violetta Iris Vasinioti +14 more
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Phloroglucinol α-Pyrones from Helichrysum: A Review on Structural Diversity, Plant Distribution and Isolation [PDF]
PlantsHelichrysum species (Asteraceae) are renowned for their diverse phytochemical profiles and traditional medicinal applications. Among their specialized metabolites, phloroglucinol-α-pyrone derivatives represent a structurally unique and pharmacologically ...
Yulian Voynikov
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α-Pyrone Polyketides from Streptomyces ambofaciens BI0048, an Endophytic Actinobacterial Strain Isolated from the Red Alga Laurencia glandulifera [PDF]
Marine Drugs, 2017 Four new (1–4) and six previously reported (5–10) α-pyrone polyketides, along with benzoic acid, hydrocinnamic acid, and (E)-cinnamic acid, were isolated from the organic extract resulting from the cultivation of the algicolous strain Streptomyces ...
Enikő Rab +3 more
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α-Pyrone Derivatives from a Streptomyces Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells [PDF]
Natural Products and Bioprospecting, 2017 Tamoxifen resistance (TamR) is the underlying cause of treatment failure in many breast cancer patients receiving tamoxifen. In order to look for noncytotoxic natural products with the ability to reverse TamR, an extract from strain Streptomyces sp.
Rui-Min Yang +8 more
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Biosynthesis-Guided Discovery and Engineering of α-Pyrone Natural Products from Type I Polyketide Synthases. [PDF]
ACS Chem Biol, 2023 Natural products containing the α-pyrone moiety are produced by polyketide synthases (PKSs) in bacteria, fungi, and plants. The conserved biosynthetic logic for the production of the α-pyrone moiety involves the cyclization of a triketide intermediate ...
Yi D, Agarwal V.
europepmc +2 more sources
Gombapyrones E and F, New α-Pyrone Polyenes Produced by Streptomyces sp. KMC-002
Molecules, 2011 Microorganism-derived polyene polyketides have been shown to display a variety of biological activities and have attracted great interest due to their structurally intriguing chemical diversity.
Kang Ro Lee +3 more
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Parafenestella varangrensis sp. nov., a phomenin producing fungus from the Arctic [PDF]
Scientific ReportsDriftwood-associated fungi are a less recognized source of secondary metabolites with diverse biological activities. The main aim of this study was to characterize a driftwood-associated Parafenestella (Pleosporales, Ascomycota) species and evaluate the ...
Sailesh Maharjan +6 more
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Two new -Methoxy--Pyrones From the Mangrove Sediment-Derived SCSIO NS126
Natural Product Communications, 2021 Two new α -methoxy- γ -pyrone analogs, 2-methoxy-3-methyl-5,6-diethyl- γ -pyrone ( 2 ) and 2-methoxy-3,5-dimethyl-6-propyl- γ -pyrone ( 3 ), together with 2-methoxy-3,5-dimethyl-6-ethyl- γ -pyrone ( 1 ), firstly isolated from natural sources, were ...
Kunlong Li +6 more
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New Antiproliferative Dibenzo-α-Pyrone From Whole Plants of
Natural Product Communications, 2021 A new compound, 1,3,7,9-tetrahydroxy-6 H -dibenzo[ b , d ]pyran-6-one ( 1 ), together with 6 known compounds ( 2 - 7 ), was isolated from the extract of whole plants of Centella asiatica .
Yi Liu, Wei Wang, Jian Miao
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