Results 51 to 60 of about 838,732 (296)

Prevalence of Charcot-Marie-Tooth disease across the lifespan: a population-based epidemiological study

BMJ Open, 2019
ObjectivesThis population-based study aimed to determine age-standardised prevalence of Charcot-Marie-Tooth disease (CMT) across the lifespan using multiple case ascertainment sources.DesignPoint-prevalence epidemiological study in the Auckland Region of
Kelly Jones, Joshua Burns, Alice Theadom, Richard Roxburgh, Erin MacAulay, Gina O’Grady, Miriam Rodrigues, Moneeta Pal, Scott Denton, Ronelle Baker, Braden TE Ao   +10 more
doaj   +1 more source

Acute ischaemic stroke associated with SARS-CoV-2 infection in North America [PDF]

, 2022
Adam A. Dmytriw, Mahmoud Dibas, Kevin Phan, Aslan Efendizade, Johanna Ospel, Clemens M. Schirmer, Fabio Settecase, Manraj K.S. Heran, Anna Luisa Kühn, Ajit S Puri, Bijoy K. Menon, Sanjeev Sivakumar, Ashkan Mowla, Daniel Vela‐Duarte, Italo Linfante, Guilherme Dabus, Robert W. Regenhardt, Salvatore D’Amato, Joseph Rosenthal, Alicia Zha, Nafee T. Talukder, Sunil A. Sheth, Ameer E Hassan, Daniel L. Cooke, Lester Y. Leung, Adel M. Malek, Barbara Voetsch, Siddharth Sehgal, Ajay K. Wakhloo, Mayank Goyal, Hannah Wu, Jake Cohen, Sherief Ghozy, David Turkel‐Parella, Zerwa Farooq, Justin E. Vranic, James D. Rabinov, Christopher J. Stapleton, Ramandeep Minhas, Vinodkumar Velayudhan, Zeshan A. Chaudhry, Andrew Xavier, María Bres Bullrich, Sachin Pandey, Luciano A. Sposato, Stephen A. Johnson, Gaurav Gupta, Priyank Khandelwal, Latisha K. Ali, David S. Liebeskind, Mudassir Farooqui, Santiago Ortega‐Gutiérrez, Fadi Nahab, Dinesh Jillella, Karen Chen, Mohammad Ali Aziz‐Sultan, Mohamad Abdalkader, Artem Kaliaev, Thanh N. Nguyen, Diogo C Haussen, Raul G. Nogueira, Israr Ul Haq, Osama O. Zaidat, Emma Sanborn, Thabele M Leslie‐Mazwi, Aman B. Patel, James E. Siegler, Ambooj Tiwari   +67 more
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Efficacy of SGLT2 Inhibitors, GLP-1 Receptor Agonists, DPP-4 Inhibitors, and Sulfonylureas on Moderate-to-Severe COPD Exacerbations Among Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis

Pharmaceuticals
Background/Objectives: Chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) frequently coexist, contributing to worse clinical outcomes and increased risk of exacerbations. While newer glucose-lowering agents have demonstrated
Edoardo Pirera, Domenico Di Raimondo, Lucio D’Anna, Antonino Tuttolomondo   +3 more
doaj   +1 more source

Baseline Cardiovascular Risk Factor Control in Patients With Type 2 Diabetes and Coronary Disease Versus Stroke: Secondary Analysis of Cardiovascular Outcome Trials [PDF]

, 2023
Priyadarshini Balasubramanian, Walter N. Kernan, Kevin N. Sheth, Anne Pernille Ofstad, Julio Rosenstock, Christoph Wanner, Bernard Zinman, Michaela Mattheus, Nikolaus Marx, Silvio E. Inzucchi   +9 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive impairment, fatigue, and depression are common in multiple sclerosis (MS), potentially due to disruption of regional functional connectivity caused by white matter (WM) lesions. We explored whether WM lesions functionally connected to specific brain regions contribute to these MS‐related manifestations.
Alessandro Franceschini, Paolo Preziosa, Paola Valsasina, Damiano Mistri, Monica Margoni, Federica Esposito, Massimo Filippi, Maria A. Rocca   +7 more
wiley   +1 more source

Learning together for better health using an evidence-based Learning Health System framework: a case study in stroke

BMC Medicine
Background In the context of expanding digital health tools, the health system is ready for Learning Health System (LHS) models. These models, with proper governance and stakeholder engagement, enable the integration of digital infrastructure to provide ...
Helena Teede, Dominique A. Cadilhac, Tara Purvis, Monique F. Kilkenny, Bruce C.V. Campbell, Coralie English, Alison Johnson, Emily Callander, Rohan S. Grimley, Christopher Levi, Sandy Middleton, Kelvin Hill, Joanne Enticott   +12 more
doaj   +1 more source