Results 51 to 60 of about 4,020 (154)

Quinoa Ameliorates High‐Fat Diet‐Induced Obesity in Female Mice by Regulating Gut Microbiota and Adipogenesis

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
Quinoa intervention counteracts high‐fat diet (HFD)‐induced obesity in C57BL/6 female mice and elicits a concomitant increase in the relative abundance of Bacteroidota, Bacteroidia, Bacteroidales, and Muribaculaceae. Treatment with quinoa in HFD‐fed female mice results in reduced expression of genes involved in “ion channel” in gonadal white adipose ...
Yingqi Liu, Qiwen Pan, Xiaohua Bao, Yingxin Zhang, Xianjun Liu, Yue Liu, Yujie Liu, Yingxin Zhang, Qirui Xie, Zhiyong Liang, Fengjie Sun, Jing Li, Hao Li, Zhandong Li   +13 more
wiley   +1 more source

Muscle Loss in Obesity Therapy as a Therapeutic Target: Trial Design and Endpoints for Regulatory Discussions

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT The Society on Cachexia and Wasting Disorders (SCWD) convened a Regulatory and Trial Update Workshop in Washington, D.C., in December 2024, assembling experts from academic institutions, the pharmaceutical industry and the US Food and Drug Administration (FDA) for focused discussions.
Stephan von Haehling, Ryosuke Sato, Henning Langer, Muhammad Shahzeb Khan, Andrew J. S. Coats, William Evans, Steven Heymsfield, Stefan D. Anker   +7 more
wiley   +1 more source

Dynamic eIF3‐S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts

Advanced Science, Volume 12, Issue 39, October 20, 2025.
This research reveals that reduced m6A modifications during insect molting trigger liquid–liquid phase separation (LLPS) of the m6A reader eIF3‐S6, which binds and stabilizes key molting mRNAs, including EcR and Cht10. Disrupting m6A or LLPS causes cuticle remodeling defects and molting failure, highlighting the synergistic control of gene expression ...
Zhihao Hu, Yu Zhou, Huimin Wang, Yaxi Wu, Rui Han, Shili Liu, Feng Jiang, Xiaojiao Guo, Meiling Yang   +8 more
wiley   +1 more source

Drug Candidate BIO101 for Spinal Muscular Atrophy as Monotherapy or Combined With the Antisense Oligonucleotide ASO‐10‐27

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Spinal muscular atrophy (SMA) is a neuromuscular disease caused by loss of survival of motor neuron (SMN) protein inducing progressive muscle weakness and atrophy due to motor neurons degeneration. Despite benefits of SMN restoration therapies in patients, motor defects are still persistent.
Cynthia Bézier, Steve Cottin, Parvin Nazari Hashemi, Mirella El Khoury, Zoé Clerc, Christine Balducci, Delphine Sapaly, Laure Weill, René Lafont, Stanislas Veillet, Pierre J. Dilda, Frédéric Charbonnier, Mathilde Latil, Olivier Biondi   +13 more
wiley   +1 more source

Stress in dipteran insects mass‐reared for sterile insect technique applications

Insect Science, Volume 32, Issue 5, Page 1495-1523, October 2025.
The connections between biotic and abiotic stress affecting mass‐reared dipteran insects and the associated stress and immunological responses. Numbers indicate the order in which the topics are discussed in this review. Abstract Stress may be viewed as the disturbance of homeostasis of an organism.
Caroline K. Mirieri, Vera I.D. Ros, Adly M.M. Abd‐Alla, Monique M. van Oers   +3 more
wiley   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Molecular mechanism of ATP‐binding cassette transporter‐mediated insecticide resistance

New Plant Protection, Volume 2, Issue 3, September 2025.
Advances in functional genomics (RNAi and CRISPR/Cas9) and artificial intelligence‐driven structure prediction (e.g., AlphaFold) are elucidating how ATP‐binding cassette transporters mediate insecticide resistance to both synthetic chemicals and Bacillus thuringiensis toxins.
Yuntong Lv, Pengcheng Wang, Zihan Wei, Xueqing Yang   +3 more
wiley   +1 more source

Neuroprotective Effect of Mas Activation by BIO101 in Vincristine‐Induced Small Fiber Neuropathy

Journal of the Peripheral Nervous System, Volume 30, Issue 3, September 2025.
ABSTRACT Background and Aims Chemotherapy‐induced peripheral neuropathy (CIPN) is a significant side effect that limits the dosage of many anticancer therapies, such as vincristine. At present, there are no effective pharmacological treatments to prevent CIPN.
Simon Frachet, Aurore Danigo, Mathilde Latil, Pierre J. Dilda, Flavien Bessaguet, Laurence Richard, Franck Sturtz, Laurent Magy, Claire Demiot   +8 more
wiley   +1 more source

miR-34-5p mediates 20E-induced autophagy in the fat body of Bombyx mori by targeting Atg1

BMC Genomics
Background 20-Hydroxyecdysone (20E) is an important hormone that regulates insect development and metamorphosis. The fat body of insects plays a crucial role in nutrient storage and energy metabolism and is considered the exchange center for regulating ...
Huili Qiao, Ziqian Tong, Yuanzhuo Wang, Juanjuan Yang, Yanyan Sun, Huixuan Shi, Zhuo Liu, Jianping Duan, Dandan Li, Yunchao Kan   +9 more
doaj   +1 more source

Disrupting shadow in the prothoracic gland induced larval development arrest in the fall armyworm Spodoptera frugiperda

Frontiers in Physiology
IntroductionThe juvenile hormone (JH) and 20-hydroxyecdysone (20E) are the central regulating hormones of insect development. The timing of their secretion usually leads to developmental transitions.MethodsThe developmental transitions were evaluated via
Mian-Zhi Wu, Mian-Zhi Wu, Shu-Ting Fan, Shu-Ting Fan, Yuan-Chen Zhang, Jin-Fang Tan, Jin-Fang Tan, Guan-Heng Zhu, Guan-Heng Zhu   +8 more
doaj   +1 more source