Results 71 to 80 of about 8,241 (215)

Pharmacological intervention: Challenges and promising outcomes for fat loss and preservation of lean body mass in the treatment of overweight and type 2 diabetes

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 803-816, February 2026.
Abstract Treatment with GLP‐1 receptor agonists (GLP‐1 RAs) is effective in reducing body weight in individuals with overweight and type 2 diabetes (T2D). However, measurements indicate that a considerable portion of the weight loss derives from fat‐free mass (FFM), including skeletal muscle, which may compromise metabolic health and physical function.
Viktor Aimelet, Jens Juul Holst
wiley   +1 more source

Timing is everything: PTTH mediated DHR4 nucleocytoplasmic trafficking sets the tempo of Drosophila steroid production

open access: yesFrontiers in Endocrinology, 2011
During development multicellular organisms must become sexually mature to reproduce. But what underlying developmental clock times this transition? Recent data shows that in fly larvae, nuclear-cytoplasmic trafficking of DHR4, a nuclear receptor, in ...
Kim F Rewitz, Michael B. O'Connor
doaj   +1 more source

20-Hydroxyecdysone Primes Innate Immune Responses That Limit Bacterial and Malarial Parasite Survival in Anopheles gambiae

open access: yesmSphere, 2020
Blood feeding is an integral behavior of mosquitoes to acquire nutritional resources needed for reproduction. This requirement also enables mosquitoes to serve as efficient vectors to acquire and potentially transmit a multitude of mosquito-borne ...
Rebekah A. Reynolds   +2 more
doaj   +1 more source

A Systems Biology Approach Reveals a Calcium-Dependent Mechanism for Basal Toxicity in Daphnia magna. [PDF]

open access: yes, 2015
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Environmental Science & Technology, copyright © American Chemical Society after peer review and technical editing by the publisher.The expanding ...
Antczak, Philip   +7 more
core   +1 more source

Quinoa Ameliorates High‐Fat Diet‐Induced Obesity in Female Mice by Regulating Gut Microbiota and Adipogenesis

open access: yesFood Science &Nutrition, Volume 13, Issue 12, December 2025.
Quinoa intervention counteracts high‐fat diet (HFD)‐induced obesity in C57BL/6 female mice and elicits a concomitant increase in the relative abundance of Bacteroidota, Bacteroidia, Bacteroidales, and Muribaculaceae. Treatment with quinoa in HFD‐fed female mice results in reduced expression of genes involved in “ion channel” in gonadal white adipose ...
Yingqi Liu   +13 more
wiley   +1 more source

Trade-offs between personal immunity and reproduction in the burying beetle, N. vespilloides [PDF]

open access: yes, 2014
We know that parental investment and immune investment are costly processes, but it is unclear which trait will be prioritised when both may be required.
Cotter, Sheena C.   +3 more
core   +2 more sources

Muscle Loss in Obesity Therapy as a Therapeutic Target: Trial Design and Endpoints for Regulatory Discussions

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT The Society on Cachexia and Wasting Disorders (SCWD) convened a Regulatory and Trial Update Workshop in Washington, D.C., in December 2024, assembling experts from academic institutions, the pharmaceutical industry and the US Food and Drug Administration (FDA) for focused discussions.
Stephan von Haehling   +7 more
wiley   +1 more source

交尾依存的な生殖幹細胞増殖を制御する神経内分泌機構の追究 [PDF]

open access: yes, 2018
この博士論文は内容の要約のみの公開(または一部非公開)になっています筑波大学 (University of Tsukuba ...
AMEKU Tomotsune, 天久 朝恒
core   +1 more source

Mechanisms regulating nutrition-dependent developmental plasticity through organ-specific effects in insects [PDF]

open access: yes, 2013
Nutrition, via the insulin/insulin-like growth factor (IIS)/Target of Rapamycin (TOR) signaling pathway, can provide a strong molding force for determining animal size and shape.
Koyama, Takashi   +2 more
core   +2 more sources

Dynamic eIF3‐S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts

open access: yesAdvanced Science, Volume 12, Issue 39, October 20, 2025.
This research reveals that reduced m6A modifications during insect molting trigger liquid–liquid phase separation (LLPS) of the m6A reader eIF3‐S6, which binds and stabilizes key molting mRNAs, including EcR and Cht10. Disrupting m6A or LLPS causes cuticle remodeling defects and molting failure, highlighting the synergistic control of gene expression ...
Zhihao Hu   +8 more
wiley   +1 more source

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