Results 161 to 170 of about 80,587 (292)

Chemical Induction of MYC Protein Degradation via MYC-MAX Disruption and 20S Proteasome Activation. [PDF]

ACS Chem Biol
Olatunde MO, Tepe JJ.
europepmc   +1 more source

Structure, Function, and Allosteric Regulation of the 20S Proteasome by the 11S/PA28 Family of Proteasome Activators. [PDF]

Biomolecules, 2023
Thomas T, Salcedo-Tacuma D, Smith DM.
europepmc   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

20S proteasome-regulated proteostasis in ELVAs is critical for oocyte-to-embryo transition and female fertility. [PDF]

EMBO J
Rong Y, Chen Y, Cao H, Liu C, Xu H, Tong X, Fang A, Ai L, Zhu Y, Zhang Y, Ren P, Li X, Gao Y, Tian X, He L, Zhang S, Yu C.   +16 more
europepmc   +1 more source

Structural and functional characteristics and expression profile of the 20S proteasome gene family in Sorghum under abiotic stress. [PDF]

Front Plant Sci, 2023
Malik V, Ikram FM, Singh Y, Kumar V, Malik P, Balyan P, Singh KP, Mir RR, Hashem A, Avila-Quezada GD, Abd Allah EF, Kumar U.   +11 more
europepmc   +1 more source

Novel beta-lactam derivatives: potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome.

, 2007
A series of beta-lactam derivatives has been designed and synthesized to inhibit the chymotrypsin-like activity of the human 20S proteasome. The most potent compounds of this new structural class of beta-subunit selective 20S proteasome inhibitors ...
Guagnano, Vito, Furet, Pascal, Imbach, Patricia, Roesel, Johannes, Garcia-Echeverria, Carlos, Bitsch, Francis, Rihs, Grety, Noorani, Maria, Lang, Marc   +8 more
core  

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

Oleanolic Acid Amide Derivatives as 20s Proteasome Stimulators. [PDF]

Chembiochem
Osman JM, Dantis DS, King H, Trader DJ.
europepmc   +1 more source

Dual Repression by IPA1 Fine‐Tunes OsbZIP79‐Mediated Salt Tolerance in Rice

Advanced Science, EarlyView.
Dual repression by IPA1 fine‐tunes OsbZIP79‐mediated salt tolerance in rice: direct transcriptional inhibition under normal conditions and salt‐induced degradation under stress. This dual mechanism activates OsbZIP79 to regulate Na+/K+ homeostasis and redox balance via downstream genes, enabling optimal salt stress response.
Hui Wang, Bo Liu, Can Hu, Chenfan Zheng, Yuting Wei, Xier Xu, Wei Yang, Yu Fang, Guangle Shen, Pedro García‐Caparros, Conghe Zhang, Qingyao Shu, Meng Jiang   +12 more
wiley   +1 more source

The constitutive 20S proteasome is required for the maintenance and differentiation of spermatogonia in mice. [PDF]

J Adv Res
Fang A, Cao H, Zhang Y, Wu J, Zhang Q, Xu L, Yu C.   +6 more
europepmc   +1 more source