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Structure and structure formation of the 20S proteasome
Molecular Biology Reports, 1997Eukaryotic 20S proteasomes are complex oligomeric proteins. The maturation process of the 14 different alpha- and beta-subunits has to occur in a highly coordinate manner. In addition beta-subunits are synthesized as proproteins and correct processing has to be guaranteed during complex maturation. The structure formation can be subdivided in different
M, Schmidt, G, Schmidtke, P M, Kloetzel
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DETECTION OF ANTIBODIES TO THE 20S PROTEASOME BY ELISA
Journal of Immunoassay and Immunochemistry, 2013The presence of antibodies against the 20S proteasome has been correlated with diseases like multiple sclerosis (MS) and systemic lupus erythematosus (SLE) but no definite association has been established. In order to investigate this further, we optimized an ELISA for proteasome antibodies and applied it to test a total of 324 serum and plasma samples
Karin Meinike, Jørgensen +3 more
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20S proteasomes and protein degradation “by default”
BioEssays, 2006AbstractThe degradation of the majority of cellular proteins is mediated by the proteasomes. Ubiquitin‐dependent proteasomal protein degradation is executed by a number of enzymes that interact to modify the substrates prior to their engagement with the 26S proteasomes.
Gad, Asher, Nina, Reuven, Yosef, Shaul
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Molecular Structures of 20S and 26S Proteasomes
Enzyme and Protein, 2017Eukaryotic proteasomes are unusually large protein complexes with characteristic sets of subunits and have been classified into two isoforms with apparent sedimentation coefficients of 20S and 26S, respectively. The 20S proteasome (previously named the multicatalytic proteinase complex) is a cylindrical particle with a molecular weight (MW) of ...
N, Tanahashi +3 more
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The 11S Regulators of 20S Proteasome Activity
2002Although substantial progress has been made in understanding the biochemical properties of 11S regulators since their discovery in 1992, we still only have a rudimentary understanding of their biological role. As discussed above, we have proposed a model in which the alpha/beta complex promotes the production of antigenic peptides by opening the exit ...
C P, Hill, E I, Masters, F G, Whitby
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Degradation of oxidized proteins by the 20S proteasome
Biochimie, 2001Oxidatively modified proteins are continuously produced in cells by reactive oxygen and nitrogen species generated as a consequence of aerobic metabolism. During periods of oxidative stress, protein oxidation is significantly increased and may become a threat to cell survival.
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Structural Insights into Substrate Recognition and Processing by the 20S Proteasome
Biomolecules, 2021Michael Glickman +2 more
exaly
Characterization of Fully Recombinant Human 20S and 20S-PA200 Proteasome Complexes
Molecular Cell, 2019Paula Da Fonseca, Ana Toste Rego
exaly