Results 91 to 100 of about 240,893 (243)

Acoustic Measures Capture Speech Dysfunction in Spinocerebellar Ataxia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxias (SCA) are hereditary cerebellar degenerative disorders with a common feature of dysarthria, involving impaired phonatory and articulatory control of speech, thereby affecting social communication. In this study, we investigated whether acoustic measures could objectively measure speech dysfunction and identify
Zena Fadel, Charlotte Hennessey, Hannah Lee, Pia Parekh, Sheng‐Han Kuo, Ami Kumar   +5 more
wiley   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source

StarD5 modulates B cell cholesterol synthesis and IgG1 plasma cell differentiation

Biochemistry and Biophysics Reports
StarD5 is an ER stress protein that binds cholesterol and transfers it to the plasma membrane. It additionally binds and regulates 25-hydroxycholesterol (25-HC) levels. However the full function of the StarD5-25-HC axis is unknown.
Anuj Tharakan, Daniel Rodriguez-Agudo, Sheela Damle, Genta Kakiyama, William M. Pandak, Gregorio Gil, Rebecca K. Martin   +6 more
doaj   +1 more source

Long distance regularization in chiral perturbation theory with decuplet [PDF]

, 2002
We investigate the use of long distance regularization in SU(3) baryon chiral perturbation theory with decuplet fields. The one-loop decuplet contributions to the octet baryon masses, axial couplings, S-wave nonleptonic hyperon decays and magnetic ...
A.W. Thomas, B. Borasoy, B. Borasoy, B. Borasoy, B. Borasoy, B. Borasoy, B. Borasoy, B. Borasoy, B. R. Holstein, B.R. Holstein, B.W. Lee, D.B. Leinweber, D.B. Leinweber, D.G. Caldi, E. Jenkins, E. Jenkins, G.A. Miller, H. Sugawara, J. Bijnens, J. Gasser, J. Gasser, J.F. Donoghue, J.F. Donoghue, M. Gell-Mann, M. Roos, P.-P. A. Ouimet, P.G. Ratcliffe, P.J.A. Bicudo, R. Lewis, R. Lewis, S. Okubo, S. Zhu, S.J. Puglia, S.V. Wright, U.-G. Meissner, U.-G. Meißner, V. Bernard, V. Cirigliano   +37 more
core   +3 more sources

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

25-Hydroxyvitamin D, IL-31, and IL-33 in Children with Allergic Disease of the Airways

Mediators of Inflammation, 2014
Low vitamin D is involved in allergic asthma and rhinitis. IL-31 and IL-33 correlate with Th2-associated cytokines in allergic disease. We investigated whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of ...
Anna Bonanno, Sebastiano Gangemi, Stefania La Grutta, Velia Malizia, Loredana Riccobono, Paolo Colombo, Fabio Cibella, Mirella Profita   +7 more
doaj   +1 more source

Mining for Oxysterols in Cyp7b1^−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5

Biomolecules, 2019
Deficiency in cytochrome P450 (CYP) 7B1, also known as oxysterol 7α-hydroxylase, in humans leads to hereditary spastic paraplegia type 5 (SPG5) and in some cases in infants to liver disease.
Anna Meljon, Peter J. Crick, Eylan Yutuc, Joyce L. Yau, Jonathan R. Seckl, Spyridon Theofilopoulos, Ernest Arenas, Yuqin Wang, William J. Griffiths   +8 more
doaj   +1 more source

Brainstem and Cerebellar Volume Loss and Associated Clinical Features in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel, Timothy P. Siejka, Cassandra Marotta, Josh J. Y. Lee, Kelly Bertram, Terence J. O'Brien, Meng Law, Lucy Vivash, Ian H. Harding   +8 more
wiley   +1 more source

Toxoplasma gondii-induced host’s high secretion of 25-hydroxycholesterol for immunoprotection

Parasites & Vectors
Background Toxoplasma gondii, a parasitic protozoan affecting approximately one-third of global population, causes opportunistic toxoplasmosis. It penetrates barriers to immune-privileged sites, causing encephalitis, retinochoroiditis, and fetal damage ...
Zi-Han Yang, Wei-Ling Wu, Jia-Jia Zheng, Chi Zhang, Ying-Ying Lu, Hong-Juan Peng   +5 more
doaj   +1 more source

Aetiology of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2018
Incidence, severity, and risk factors for hemorrhagic cystitis (HC) were assessed in 267 patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). HC was diagnosed in 14.6% (39 patients) within 1-139 days after allo-HSCT (median
Vasilieva V.A., Parovichnikova E.N., Drokov M.Yu., Kuzmina L.A., Klyasova G.A., Tikhomirov D.S., Tupoleva T.A., Koroleva O.M., Dubnyak D.S., Mikhaltsova E.D., Popova N.N., Konova Z.V., Savchenko V.G.   +12 more
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