Dormant Metastases Exhibit a Unique Phenotype Primarily Promoted by the Ch25h Gene and Are Maintained in Dormancy by T Lymphocytes [PDF]
MedCommDuring the course of cancer, metastatic cells frequently enter a state of dormancy that can be controlled by the immune system. In our laboratory, we developed a preclinical mouse model of metastatic immunodormancy.
Irène Romero, Angel García-Lora
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25-Hydroxycholesterol Restricts Japanese Encephalitis Virus via Metabolic Suppression of the SREBP2-Mediated Signaling Axis [PDF]
MicroorganismsHost lipid metabolism is a critical determinant of viral pathogenesis. Although the interferon-inducible cholesterol 25-hydroxylase (CH25H) typically acts as a broad-spectrum antiviral protein, its expression and regulatory patterns during Japanese ...
Xinlei Liu +9 more
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Cholesterol Reprograms Oxysterol Metabolism via the LOX1/CH25H/CYP7B1 Signaling Axis to Drive Multidrug Resistance in Colorectal Cancer. [PDF]
Hum MutatChemotherapeutic resistance remains a major contributor to tumor recurrence and unfavorable clinical outcomes in colorectal cancer (CRC). Although cholesterol metabolic reprogramming has been implicated in tumorigenesis, metastasis, and drug resistance across multiple malignancies, its specific role in CRC chemoresistance requires systematic ...
Cheng H +6 more
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Acta Biochimica Et Biophysica Sinica, 2022 Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent metabolic disorder all over the world, and lipid metabolic disorders and inflammation are closely associated and contribute to the pathogenesis of NAFLD. Cholesterol 25-hydroxylase
Yaqiong Wang, Jin Zhang, Pei Qiu
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Interferon-induced miR-7705 modulates the anti-virus activity of cholesterol 25-hydroxylase [PDF]
Journal of VirologyCholesterol 25-hydroxylase (CH25H), an interferon-stimulated gene (ISG), has been implicated in broad-spectrum antiviral immunity. Here, we identify CH25H as a potent suppressor of hepatitis B virus (HBV) replication that significantly outperforms IFN-α ...
Le Wang +11 more
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Molecular Metabolism, 2020 Objective: Expansion of visceral adipose tissue (VAT) and metabolic inflammation are consequences of obesity and associated with type 2 diabetes (T2DM).
Lucia Russo +2 more
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Frontiers in Pharmacology, 2021 Osteoarthritis (OA) is a worldwide degenerative joint disease that seriously impaired the quality of life of patients. OA has been established as a disease with metabolic disorder.
Xiaoqing Shi +2 more
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Leukocyte CH25H is a potential diagnostic and prognostic marker for lung adenocarcinoma
Scientific Reports, 2022 Metastasis, a major challenge during the treatment of lung cancer, causes deterioration in patient health outcomes. Thus, to address this problem, this study aimed to explore the role and contribution of Cholesterol 25-Hydroxylase (CH25H) as a potential ...
Guo Dawei, Gu Wenchao, Hu Xun
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A CRISPR activation screen identifies CH25H as a restriction factor against influenza viruses by targeting accessible cholesterol [PDF]
Emerging Microbes and InfectionsInfluenza A viruses (IAVs) cause severe outbreaks with high mortality in birds and humans. A deeper understanding of cell-intrinsic defense mechanisms against influenza viruses is therefore crucial for developing novel antiviral strategies.
Jinyu Huang +15 more
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Chicken CH25H inhibits ALV-J replication by promoting cellular autophagy
Frontiers in Immunology, 2023 Autophagy plays an important role in host antiviral defense. The avian leukosis virus subgroup J (ALV-J) has been shown to inhibit autophagy while promoting viral replication. The underlying autophagic mechanisms, however, are unknown.
Tingting Xie, Min Feng, Xiquan Zhang
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