Results 31 to 40 of about 2,414 (116)

25-Hydroxycholesterol exacerbates vascular leak during acute lung injury

JCI Insight, 2023
Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung biology is poorly defined.
Jennifer H. Madenspacher, Eric D. Morrell, Jeffrey G. McDonald, Bonne M. Thompson, Yue Li, Konstantin G. Birukov, Anna A. Birukova, Renee D. Stapleton, Aidin Alejo, Peer W. Karmaus, Julie M. Meacham, Prashant Rai, Carmen Mikacenic, Mark M. Wurfel, Michael B. Fessler   +14 more
doaj   +1 more source

Research progress on the mechanism of cholesterol-25-hydroxylase in intestinal immunity

Frontiers in Immunology, 2023
Inflammatory bowel disease (IBD), a general term encompassing Crohn’s disease (CD) and ulcerative colitis (UC), and other conditions, is a chronic and relapsing autoimmune disease that can occur in any part of the digestive tract.
Guoqiang Zhong, Chengcheng He, Shanping Wang, Chuangzhen Lin, Mingsong Li   +4 more
doaj   +1 more source

Disruption of cholesterol homeostasis triggers periodontal inflammation and alveolar bone loss

Experimental and Molecular Medicine, 2023
Oral diseases exhibit a significant association with metabolic syndrome, including dyslipidemia. However, direct evidence supporting this relationship is lacking, and the involvement of cholesterol metabolism in the pathogenesis of periodontitis (PD) has
Thanh-Tam Tran, Gyuseok Lee, Yun Hyun Huh, Ki-Ho Chung, Sun Young Lee, Ka Hyon Park, Seung Hee Kwon, Min-Suk Kook, Jang-Soo Chun, Jeong-Tae Koh, Je-Hwang Ryu   +10 more
doaj   +1 more source

Involvement of CCL2 and CH25H Genes and TNF signaling pathways in mast cell activation and pathogenesis of chronic spontaneous urticaria

Frontiers in Immunology, 2023
Chronic spontaneous urticaria (CSU), a mast cell-driven disease, substantially affects the quality of life. While genetics affect CSU susceptibility and severity, the specific genetic factors associated with mast cell activation in CSU remain elusive. We
Xiaobin Fang, Yueyi Weng, Xiaochun Zheng, Xiaochun Zheng, Xiaochun Zheng   +4 more
doaj   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Rapid GPR183-mediated recruitment of eosinophils to the lung after Mycobacterium tuberculosis infection

Cell Reports, 2022
Summary: Influx of eosinophils into the lungs is typically associated with type II responses during allergy and fungal and parasitic infections. However, we previously reported that eosinophils accumulate in lung lesions during type I inflammatory ...
Andrea C. Bohrer, Ehydel Castro, Claire E. Tocheny, Maike Assmann, Benjamin Schwarz, Eric Bohrnsen, Michelle A. Makiya, Fanny Legrand, Kerry L. Hilligan, Paul J. Baker, Flor Torres-Juarez, Zhidong Hu, Hui Ma, Lin Wang, Liangfei Niu, Zilu Wen, Sang H. Lee, Olena Kamenyeva, Keith D. Kauffman, Michele Donato, Alan Sher, Daniel L. Barber, Laura E. Via, Thomas J. Scriba, Purvesh Khatri, Yanzheng Song, Ka-Wing Wong, Catharine M. Bosio, Amy D. Klion, Katrin D. Mayer-Barber   +29 more
doaj   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

Journal of Neuroinflammation, 2020
Background Genome-wide association studies of Alzheimer’s disease (AD) have implicated pathways related to lipid homeostasis and innate immunity in AD pathophysiology.
Man Ying Wong, Michael Lewis, James J. Doherty, Yang Shi, Anil G. Cashikar, Anna Amelianchik, Svitlana Tymchuk, Patrick M. Sullivan, Mingxing Qian, Douglas F. Covey, Gregory A. Petsko, David M. Holtzman, Steven M. Paul, Wenjie Luo   +13 more
doaj   +1 more source

Single‐Cell Profiling Identifies SLC2A5‐Mediated Fructose Metabolism as a Vulnerability in Primary CNS Lymphoma

Advanced Science, EarlyView.
Glucose deprivation in the primary CNS lymphoma (PCNSL) tumor microenvironment drives SLC2A5 (encoding GLUT5)‐dependent fructose metabolism in tumor cells, while hypoxia induces HIF‐mediated SLC2A5 expression in tumor‐supportive macrophages, revealing SLC2A5‐driven fructose utilization as a shared and targetable metabolic vulnerability across malignant
Qiaoli Wu, Qianru Zhang, Wenqiang Yan, Lu Sun, Yiran Cui, Bolin Liu, Guoqing Han, Feng Zhang, Ke Pu, Mingchao Zhang, Xiaobing Zhang, Qingguo Li, Gang An, Yuxuan Liu   +13 more
wiley   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source