Results 1 to 10 of about 25,663 (167)

Research progress on the mechanism of cholesterol-25-hydroxylase in intestinal immunity [PDF]

Frontiers in Immunology, 2023
Inflammatory bowel disease (IBD), a general term encompassing Crohn’s disease (CD) and ulcerative colitis (UC), and other conditions, is a chronic and relapsing autoimmune disease that can occur in any part of the digestive tract.
Guoqiang Zhong, Chengcheng He, Shanping Wang, Chuangzhen Lin, Mingsong Li   +4 more
doaj   +4 more sources

Hepatic Reduction in Cholesterol 25-Hydroxylase Aggravates Diet-induced SteatosisSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti-inflammatory and antiviral activities.
Zeyu Dong, Fangzhou He, Xiaosong Yan, Yuanming Xing, Yuyang Lei, Jie Gao, Ming He, Dongmin Li, Liang Bai, Zuyi Yuan, John Y-J. Shyy   +10 more
doaj   +5 more sources

Cholesterol 25-hydroxylase suppresses avian reovirus replication by its enzymatic product 25-hydroxycholesterol [PDF]

Frontiers in Microbiology, 2023
Avian reovirus (ARV) causing viral arthritis/tenosynovitis and viral enteritis in domestic fowl has significantly threatened on the poultry industry worldwide. ARV is a non-enveloped fusogenic virus that belongs to the Reoviridae family.
Yuyang Wang, Yuyang Wang, Wei Zuo, Yangyang Zhang, Zongyi Bo, Zongyi Bo, Chengcheng Zhang, Xiaorong Zhang, Yantao Wu, Yantao Wu   +9 more
doaj   +4 more sources

Dual-Role of Cholesterol‐25‐Hydroxylase in Regulating Hepatitis B Virus Infection and Replication [PDF]

mBio, 2022
Hepatitis B virus (HBV)‐related diseases are among the major diseases that affect millions of people worldwide. These diseases are difficult to eradicate and thus pose a serious global health challenge.
Qi Wei, Hongxiao Song, Yanli Gao, Fengchao Xu, Qingfei Xiao, Fei Wang, Bingxin Lei, Junqi Niu, Pujun Gao, Haichun Ma, Guangyun Tan   +10 more
doaj   +4 more sources

Heightened cholesterol 25-hydroxylase expression in aged lung during Streptococcus pneumoniae [PDF]

Frontiers in Aging
IntroductionAlveolar macrophages (AM) are critical effectors of the immune response and are essential for host responses to Streptococcus pneumoniae. Changes in lipid metabolism in AM can alter cellular function and biology.
David G. Thomas, David G. Thomas, Jianjun Yang, Soo Jung Cho, Soo Jung Cho, Heather Stout-Delgado   +5 more
doaj   +4 more sources

25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism[S] [PDF]

Journal of Lipid Research, 2018
Cholesterol 25-hydroxylase (CH25H) catalyzes the production of 25-hydroxycholesterol (25-HC), an oxysterol that can play an important role in different biological processes.
Ying Liu, Zhuo Wei, Xingzhe Ma, Xiaoxiao Yang, Yuanli Chen, Lei Sun, Chuanrui Ma, Qing R. Miao, David P. Hajjar, Jihong Han, Yajun Duan   +10 more
doaj   +5 more sources

Thrombin increases the expression of cholesterol 25-hydroxylase in rat astrocytes after spinal cord injury [PDF]

Neural Regeneration Research, 2023
Astrocytes are important cellular centers of cholesterol synthesis and metabolism that help maintain normal physiological function at the organism level. Spinal cord injury results in aberrant cholesterol metabolism by astrocytes and excessive production
Chen Chen, Huiyuan Ji, Nan Jiang, Yingjie Wang, Yue Zhou, Zhenjie Zhu, Yuming Hu, Yongjun Wang, Aihong Li, Aisong Guo   +9 more
doaj   +4 more sources

Pan-cancer multi-dimensional characterization and biological significance of cholesterol 25-hydroxylase (CH25H) [PDF]

Discover Oncology
Background CH25H encodes an interferon-inducible hydroxylase that converts cholesterol to 25-hydroxycholesterol (25-HC), linking lipid homeostasis to immune regulation. Its pan-cancer relevance remains incompletely defined.
Zhongqi Diao, Yi Chen, Wenjia Guo
doaj   +4 more sources

Interferon-induced miR-7705 modulates the anti-virus activity of cholesterol 25-hydroxylase [PDF]

Journal of Virology
Cholesterol 25-hydroxylase (CH25H), an interferon-stimulated gene (ISG), has been implicated in broad-spectrum antiviral immunity. Here, we identify CH25H as a potent suppressor of hepatitis B virus (HBV) replication that significantly outperforms IFN-α ...
Le Wang, Hongxiao Song, Fengchao Xu, Yujia Zhu, Mian Huang, Jing Xu, Xiaolu Li, Fei Wang, Fan Yang, Yang Lei, Pujun Gao, Guangyun Tan   +11 more
doaj   +4 more sources

Hepatic Cholesterol-25-Hydroxylase Overexpression Improves Systemic Insulin Sensitivity in Mice [PDF]

Journal of Diabetes Research, 2017
Obesity is a major risk factor for several diseases including diabetes, heart disease, and some forms of cancer and due to its rapidly increasing prevalence it has become one of the biggest problems medicine is facing today.
Britta Noebauer, Alexander Jais, Jelena Todoric, Klaus Gossens, Hedwig Sutterlüty-Fall, Elisa Einwallner   +5 more
doaj   +5 more sources