Results 11 to 20 of about 25,663 (167)

Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes [PDF]

Molecular Metabolism, 2020
Objective: Expansion of visceral adipose tissue (VAT) and metabolic inflammation are consequences of obesity and associated with type 2 diabetes (T2DM).
Lucia Russo, Lindsey Muir, Lynn Geletka, Jennifer Delproposto, Nicki Baker, Carmen Flesher, Robert O'Rourke, Carey N. Lumeng   +7 more
doaj   +4 more sources

Cholesterol-25-hydroxylase Is a Chicken ISG That Restricts ALV-J Infection by Producing 25-hydroxycholesterol [PDF]

Viruses, 2019
The avian leukosis virus subgroup J (ALV-J) belongs to the chicken retrovirus that causes enormous economic losses in the poultry industry. Interferon-stimulated genes (ISGs) are critical for controlling virus infections.
Tingting Xie, Min Feng, Manman Dai, Guodong Mo, Zhuohao Ruan, Guiyan Wang, Meiqing Shi, Xiquan Zhang   +7 more
doaj   +5 more sources

Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection [PDF]

Cells, 2023
Alveolar macrophages (AM) are long-lived tissue-resident innate immune cells of the airways. AM are key effectors of recognition, initiation, and resolution of the host defense against microbes and play an essential role in mediating host responses to ...
Soo Jung Cho, Alexander Pronko, Jianjun Yang, Kassandra Pagan, Heather Stout-Delgado   +4 more
doaj   +4 more sources

Cholesterol 25‐Hydroxylase Protects Against Diabetic Kidney Disease by Regulating ADP Ribosylation Factor 4 [PDF]

Advanced Science
Cholesterol 25‐hydroxylase (CH25H), an enzyme involved in cholesterol metabolism, regulates inflammatory responses and lipid metabolism. However, its role in kidney disease is not known.
Lu Zhang, Zhengying Fang, Qingqing Zhu, Shumin Yang, Jia Fu, Zeguo Sun, Geming Lu, Chengguo Wei, Zhi Zhang, Kyung Lee, Yifei Zhong, Ruijie Liu, John Cijiang He   +12 more
doaj   +4 more sources

Marked upregulation of cholesterol 25-hydroxylase expression by lipopolysaccharide [PDF]

Journal of Lipid Research, 2009
During screening of genes upregulated by lipopolysaccharide (LPS; endotoxin) treatment of bone marrow-derived mouse macrophages, it was unexpectedly found that cholesterol 25-hydroxylase (Ch25h) was strongly upregulated.
Ulf Diczfalusy, Katarina E. Olofsson, Ann-Margreth Carlsson, Mei Gong, Douglas T. Golenbock, Olav Rooyackers, Urban Fläring, Harry Björkbacka   +7 more
doaj   +4 more sources

Cholesterol 25-Hydroxylase Suppresses Swine Acute Diarrhea Syndrome Coronavirus Infection by Blocking Spike Protein-Mediated Membrane Fusion [PDF]

Viruses, 2023
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging porcine intestinal coronavirus that can cause acute diarrhea, vomiting, rapid weight loss, and high mortality in newborn piglets.
Dakai Liu, Da Shi, Hongyan Shi, Liaoyuan Zhang, Jiyu Zhang, Miaomiao Zeng, Tingshuai Feng, Xiaoman Yang, Xin Zhang, Jianfei Chen, Zhaoyang Jing, Zhaoyang Ji, Jialin Zhang, Li Feng   +13 more
doaj   +2 more sources

Cholesterol 25-hydroxylase promotes efferocytosis and resolution of lung inflammation. [PDF]

JCI Insight, 2020
Alveolar macrophages (AM) play a central role in initiation and resolution of lung inflammation, but the integration of these opposing core functions is poorly understood. AM expression of cholesterol 25-hydroxylase (CH25H), the primary biosynthetic enzyme for 25-hydroxycholesterol (25HC), far exceeds the expression of macrophages in other tissues, but
Madenspacher JH, Morrell ED, Gowdy KM, McDonald JG, Thompson BM, Muse G, Martinez J, Thomas S, Mikacenic C, Nick JA, Abraham E, Garantziotis S, Stapleton RD, Meacham JM, Thomassen MJ, Janssen WJ, Cook DN, Wurfel MM, Fessler MB.   +18 more
europepmc   +4 more sources

Cholesterol 25-hydroxylase suppresses porcine deltacoronavirus infection by inhibiting viral entry. [PDF]

Virus Res, 2021
Cholesterol 25-hydroxylase (CH25 H) is a key enzyme regulating cholesterol metabolism and also acts as a broad antiviral host restriction factor. Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus that can cause vomiting, diarrhea, dehydration and even death in newborn piglets.
Ke W, Wu X, Fang P, Zhou Y, Fang L, Xiao S.   +5 more
europepmc   +4 more sources

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion [PDF]

Proc Natl Acad Sci U S A, 2020
Significance The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiological agent of coronavirus disease-2019 (COVID-19), has swept the world in unprecedented speed. In a few months, SARS-CoV-2 has infected millions of people and caused tens of thousands of deaths.
Zang R, Case JB, Gomez Castro MF, Liu Z, Zeng Q, Zhao H, Son J, Rothlauf PW, Hou G, Bose S, Wang X, Vahey MD, Kirchhausen T, Fremont DH, Diamond MS, Whelan SP, Ding S.   +16 more
europepmc   +9 more sources

Cholesterol 25-Hydroxylase inhibits SARS-CoV-2 and other coronaviruses by depleting membrane cholesterol. [PDF]

EMBO J, 2020
Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2 and has spread across the globe. SARS-CoV-2 is a highly infectious virus with no vaccine or antiviral therapy available to control the pandemic; therefore, it is crucial to understand the mechanisms of viral pathogenesis and the host immune responses to SARS-CoV-2.
Wang S, Li W, Hui H, Tiwari SK, Zhang Q, Croker BA, Rawlings S, Smith D, Carlin AF, Rana TM.   +9 more
europepmc   +6 more sources