Results 21 to 30 of about 25,663 (167)

Cholesterol 25-hydroxylase inhibits Newcastle disease virus replication by enzyme activity-dependent and direct interaction with nucleocapsid protein [PDF]

Journal of Virology
Newcastle disease virus (NDV) is a significant enveloped virus within the Paramyxoviridae family, posing a major threat to the global poultry industry.
Guangmei Zhu, Xianchun Zong, Mengmeng Xiao, Dan Wang, Zhe Xu, Jingtao Hu, Guilian Yang, Yanlong Jiang, Wentao Yang, Haibin Huang, Chunwei Shi, Yan Zeng, Nan Wang, Xin Cao, Jianzhong Wang, Chunfeng Wang   +15 more
doaj   +2 more sources

Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells. [PDF]

Mol Cancer Res, 2023
Abstract Cholesterol dependence is an essential characteristic of pancreatic ductal adenocarcinoma (PDAC). Cholesterol 25-hydroxylase (CH25H) catalyzes monooxygenation of cholesterol into 25-hydroxycholesterol, which is implicated in inhibiting cholesterol biosynthesis and in cholesterol ...
McBrearty N, Cho C, Chen J, Zahedi F, Peck AR, Radaelli E, Assenmacher CA, Pavlak C, Devine A, Yu P, Lu Z, Zhang H, Li J, Pitarresi JR, Astsaturov I, Cukierman E, Rustgi AK, Stanger BZ, Rui H, Fuchs SY.   +19 more
europepmc   +3 more sources

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. [PDF]

J Exp Med
Alzheimer’s disease (AD) is characterized by amyloid plaques and neurofibrillary tangles, in addition to neuroinflammation and changes in brain lipid metabolism. 25-Hydroxycholesterol (25-HC), a known modulator of both inflammation and lipid metabolism, is produced by cholesterol 25-hydroxylase encoded by Ch25h expressed as a “disease-associated ...
Toral-Rios D, Long JM, Ulrich JD, Yu J, Strickland MR, Han X, Holtzman DM, Cashikar AG, Paul SM.   +8 more
europepmc   +4 more sources

Silencing of Cholesterol 25-Hydroxylase Attenuates Lipopolysaccharide-Induced Cardiomyocyte Damage In Vitro. [PDF]

J Cell Mol Med
ABSTRACT The underlying mechanisms of sepsis‐induced myocardial dysfunction (SIMD) remain elusive, and no targeted therapies currently exist. This study aimed to explore the expression features and functional effects of cholesterol 25‐hydroxylase (CH25H) in SIMD in vitro.
Men YJ, Cheng HB, Dong YL, Gong Y, An YQ, Jin YL, Hao SN, Ma Y, Tian YP.   +8 more
europepmc   +3 more sources

Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell-mediated inflammation in the skin. [PDF]

Sci Immunol, 2021
CD4 + T cells limit pathogenic bystander T cell expansion by suppressing cholesterol biosynthesis via secreted 25-hydroxycholesterol.
Takahashi H, Nomura H, Iriki H, Kubo A, Isami K, Mikami Y, Mukai M, Sasaki T, Yamagami J, Kudoh J, Ito H, Kamata A, Kurebayashi Y, Yoshida H, Yoshimura A, Sun HW, Suematsu M, O'Shea JJ, Kanno Y, Amagai M.   +19 more
europepmc   +3 more sources

Pathogenic mycobacterium upregulates cholesterol 25-hydroxylase to promote granuloma development via foam cell formation [PDF]

iScience
Summary: Pathogenic mycobacteria orchestrate the complex cell populations known as granuloma that is the hallmark of tuberculosis. Foam cells, a lipid-rich cell-type, are considered critical for granuloma formation; however, the causative factor in foam ...
Shuang Zhou, Ding Zhang, Dan Li, Hankun Wang, Cairong Ding, Jingrui Song, Weifeng Huang, Xuan Xia, Ziwei Zhou, Shanshan Han, Zhu Jin, Bo Yan, Jacqueline Gonzales, Laura E. Via, Lu Zhang, Decheng Wang   +15 more
doaj   +2 more sources

Cholesterol 25-hydroxylase negatively regulates porcine intestinal coronavirus replication by the production of 25-hydroxycholesterol. [PDF]

Vet Microbiol, 2019
Cholesterol 25-hydroxylase (CH25H) has been shown lately to be a host restriction factor that encodes an enzyme, which catalyzes the oxidized form of cholesterol to 25-hydroxycholesterol (25HC). A series of studies have shown that 25HC activity in hosts plays a vital role in inhibiting viral infection. In this study, we explored the antiviral effect of
Zhang Y, Song Z, Wang M, Lan M, Zhang K, Jiang P, Li Y, Bai J, Wang X.   +8 more
europepmc   +3 more sources

Fish Cholesterol 25-Hydroxylase Inhibits Virus Replication via Regulating Interferon Immune Response or Affecting Virus Entry [PDF]

Frontiers in Immunology, 2019
Cholesterol 25-hydroxylase (CH25H) is an interferon (IFN)-induced gene that catalyzes the oxidation of cholesterol to 25-hydroxycholesterol (25HC), which exerts broad-spectrum antiviral function.
Ya Zhang, Liqun Wang, Liqun Wang, Xiaohong Huang, Shaowen Wang, Youhua Huang, Qiwei Qin, Qiwei Qin   +7 more
doaj   +2 more sources

Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. [PDF]

Immunity, 2013
Interferons (IFN) are essential antiviral cytokines that establish the cellular antiviral state through upregulation of hundreds of interferon-stimulated genes (ISGs), most of which have uncharacterized functions and mechanisms. We identified Cholesterol-25-hydroxylase (Ch25h) as an antiviral ISG that can convert cholesterol to a soluble antiviral ...
Liu SY, Aliyari R, Chikere K, Li G, Marsden MD, Smith JK, Pernet O, Guo H, Nusbaum R, Zack JA, Freiberg AN, Su L, Lee B, Cheng G.   +13 more
europepmc   +4 more sources

CYP46A1-Targeted Treatment Alleviates Long-Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination. [PDF]

CNS Neurosci Ther
Our findings demonstrate that CYP46A1 plays a critical role in regulating cholesterol homeostasis in microglia and that the targeting of CYP46A1 may offer a viable therapeutic approach for traumatic brain injury (TBI). The CYP46A1 activator Efavirenz reduces white matter damage by increasing the levels of the cholesterol metabolite 24OHC, thereby ...
Li L, Shi Y, Luo Q, Guo P, Jin T, Ru X, Jiang Z, Niu Y, Li W, Chen Y, Chen Z.   +10 more
europepmc   +2 more sources