Results 31 to 40 of about 25,663 (167)

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives. [PDF]

J Neurochem
Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Ruthirakuhan M, Taha AY, Swardfager W.
europepmc   +2 more sources

Genomics and proteomics of vertebrate cholesterol ester lipase (LIPA) and cholesterol 25-hydroxylase (CH25H) [PDF]

3 Biotech, 2011
Cholesterol ester lipase (LIPA; EC 3.1.1.13) and cholesterol 25-hydroxylase (CH25H; EC 1.14.99.48) play essential role in cholesterol metabolism in the body by hydrolysing cholesteryl esters and triglycerides within lysosomes (LIPA) and catalysing the formation of 25-hydroxycholesterol from cholesterol (CH25H) which acts to repress cholesterol ...
Holmes, Roger S, VandeBerg, John L, Cox, Laura A   +2 more
openaire   +3 more sources

SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization

Journal of Advanced Research, 2023
Introduction: Sterol regulatory element binding protein (SREBP) cleavage-associating protein (SCAP) is a sterol-regulated escort protein that translocates SREBPs from the endoplasmic reticulum to the Golgi apparatus, thereby activating lipid metabolism ...
Jae-Ho Lee, Sun Hee Lee, Eun-Ho Lee, Jeong-Yong Cho, Dae-Kyu Song, Young Jae Lee, Taeg Kyu Kwon, Byung-Chul Oh, Kae Won Cho, Timothy F. Osborne, Tae-Il Jeon, Seung-Soon Im   +11 more
doaj   +1 more source

Cholesterol 25-Hydroxylase on Chromosome 10q Is a Susceptibility Gene for Sporadic Alzheimer’s Disease [PDF]

Neurodegenerative Diseases, 2005
Alzheimer’s disease (AD) is the most common cause of dementia. It is characterized by β-amyloid (Aβ) plaques, neurofibrillary tangles and the degeneration of specifically vulnerable brain neurons. We observed high expression of the cholesterol 25-hydroxylase <i>(CH25H)</i> gene in specifically vulnerable brain regions of AD patients.
Papassotiropoulos, Andreas, Lambert, Jean-Charles, Wavrant-De Vrièze, Fabienne, Wollmer, M. Axel, von der Kammer, Heinz, Streffer, Johannes R., Maddalena, Alessia, Huynh, Kim-Dung, Wolleb, Sibylle, Lutjohann, Dieter, Schneider, Brigitte, Thal, Dietmar R., Grimaldi, Luigi M. E., Tsolaki, Magdalini, Kapaki, Elisabeth, Ravid, Rivka, Konietzko, Uwe, Hegi, Thomas, Pasch, Thomas, Jung, Hans, Braak, Heiko, Amouyel, Philippe, Rogaev, Evgeny I., Hardy, John, Hock, Christoph, Nitsch, Roger M.   +25 more
openaire   +5 more sources

Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols[S]

Journal of Lipid Research, 2014
Iso-octyl chain-hydroxylated oxysterols were determined in attomoles per 10,000 cells concentrations in 10,000–80,000 cultured pancreatic adenocarcinoma cells, using a sensitive, highly automated nano-LC-ESI-MS-based method.
Hanne Roberg-Larsen, Kaja Lund, Tore Vehus, Nina Solberg, Caroline Vesterdal, Dorna Misaghian, Petter Angell Olsen, Stefan Krauss, Steven Ray Wilson, Elsa Lundanes   +9 more
doaj   +1 more source

Cholesterol 25-hydroxylase expression following immune activation in response to SARS-CoV-2 infection [PDF]

Current Opinion in Lipidology, 2021
[Abstract unavailable]
Davidson, Jillian, Rotondo, Dino
openaire   +4 more sources

Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.

Journal of Lipid Research, 1979
In vivo studies have shown abnormalities in cholesterol and bile acid metabolism in primary hyperlipoproteinemia (HLP). The aim of the present investigation was to determine if the increased production of cholesterol in HLP type IV can be attributed to a
J Ahlberg, B Angelin, I Björkhem, K Einarsson, B Leijd   +4 more
doaj   +1 more source

Repression of cholesterol 7 alpha-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes.

Journal of Lipid Research, 1995
Inhibitors of protein kinases were screened for the ability to prevent the repression of cholesterol 7 alpha-hydroxylase mRNA by taurocholate in primary cultures of adult rat hepatocytes.
R T Stravitz, Z R Vlahcevic, E C Gurley, P B Hylemon   +3 more
doaj   +1 more source

Activation of liver X receptor plays a central role in antiviral actions of 25-hydroxycholesterol

Journal of Lipid Research, 2018
Production of 25-hydroxycholesterol (25HC), a potent inhibitor of viral infection, is catalyzed by cholesterol 25-hydroxylase (CH25H). We previously reported that 25HC induced CH25H expression in a liver X receptor (LXR)-dependent manner, implying that ...
Ying Liu, Zhuo Wei, Ye Zhang, Xingzhe Ma, Yuanli Chen, Miao Yu, Chuanrui Ma, Xiaoju Li, Youjia Cao, Jian Liu, Jihong Han, Xiaoxiao Yang, Yajun Duan   +12 more
doaj   +1 more source

Regulation of cholesterol 7 alpha-hydroxylase expression by sterols in primary rat hepatocyte cultures.

Journal of Lipid Research, 1995
The importance of cholesterol and “oxysterols” in the regulation of cholesterol 7 alpha-hydroxylase is not clear. Previous in vivo studies suggest that cholesterol may up-regulate cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid ...
K.C. Doerner, E.C. Gurley, Z.R. Vlahcevic, P.B. Hylemon   +3 more
doaj   +1 more source