Results 41 to 50 of about 25,663 (167)

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source

Inhibition of Marek’s Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro

Viruses, 2023
Marek’s disease virus (MDV) causes a deadly lymphoproliferative disease in chickens, resulting in huge economic losses in the poultry industry. It has been suggested that MDV suppresses the induction of type I interferons and thus escapes immune control.
Nitin Kamble, Vishwanatha R. A. P. Reddy, Ben Jackson, Faisal R. Anjum, Chidiebere C. Ubachukwu, Ajit Patil, Shahriar Behboudi   +6 more
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Identification and characterization of the cholesterol 25‐hydroxylase gene promoter

The FASEB Journal, 2009
25‐Hydroxycholesterol (25HC) is the product of the cholesterol 25‐hydroxylase (CH25H) gene, and is one of the most potent inhibitors of cholesterol synthesis, through the suppression of SREBP activation. 25HC has also been implicated in neurodegenerative disease and shown to be toxic to primary cultured ...
Dianne Josephine Watters, Jamie Nourse
openaire   +1 more source

In nonhepatic cells, cholesterol 7α-hydroxylase induces the expression of genes regulating cholesterol biosynthesis, efflux, and homeostasis

Journal of Lipid Research, 2000
CHO cells expressing the liver-specific gene product cholesterol-7α-hydroxylase showed a 6-fold increase in the biosynthesis of [14C]cholesterol from [14C]acetate, as well as increased enzymatic activities of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA)
Gary M. Spitsen, Svein Dueland, Skaidrite K. Krisans, Casey J. Slattery, Jon H. Miyake, Roger A. Davis   +5 more
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Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways.

Journal of Lipid Research, 1990
Under most experimental conditions, the activities of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA reductase) and cholesterol 7 alpha-hydroxylase, change together in parallel directions.
WM Pandak, DM Heuman, PB Hylemon, ZR Vlahcevic   +3 more
doaj   +1 more source

Tumor factors stimulate lysosomal degradation of tumor antigens and undermine their cross-presentation in lung cancer

Nature Communications, 2022
Dendritic cells (DC) present tumour antigens to T cells but this process is defective in the tumour microenvironment. Here the authors find that downregulation of cholesterol 25-hydroxylase underlies defective cross presentation of tumour antigens.
Zhen Lu, Jinyun Chen, Pengfei Yu, Matthew J. Atherton, Jun Gui, Vivek S. Tomar, Justin D. Middleton, Neil T. Sullivan, Sunil Singhal, Subin S. George, Ashley G. Woolfork, Aalim M. Weljie, Tsonwin Hai, Evgeniy B. Eruslanov, Serge Y. Fuchs   +14 more
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Ch25h and 25-HC prevent liver steatosis through regulation of cholesterol metabolism and inflammation

Acta Biochimica et Biophysica Sinica, 2022
Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent metabolic disorder all over the world, and lipid metabolic disorders and inflammation are closely associated and contribute to the pathogenesis of NAFLD. Cholesterol 25-hydroxylase
Wang Yaqiong, Zhang Jin, Chen Jie, Wang Dan, Yu Yang, Qiu Pei, Wang Qiqi, Zhao Wenbao, Li Zhao, Lei Ting   +9 more
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Metformin Alleviates Steatohepatitis in Diet-Induced Obese Mice in a SIRT1-Dependent Way

Frontiers in Pharmacology, 2021
Metformin is the first-line anti-diabetic drug for type 2 diabetes. It has been found to significantly reduce liver aminotransferase in nonalcoholic fatty liver disease (NAFLD). However, whether metformin improves NAFLD progression remains controversial.
Wan-rong Guo, Wan-rong Guo, Juan Liu, Li-dan Cheng, Li-dan Cheng, Zi-yu Liu, Zi-yu Liu, Xiao-bin Zheng, Xiao-bin Zheng, Hua Liang, Hua Liang, Fen Xu, Fen Xu   +12 more
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Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons [PDF]

Journal of Leukocyte Biology, 2010
Abstract TLR-mediated induction of cholesterol 25-hydoxylase transcription in dendritic cells and macrophages is dependent on IFN-α/IFN-β and signaling through INF-αR and STAT1. The oxysterol-producing enzyme CH25H plays an important role in regulating lipid metabolism, gene expression, and immune activation.
Kiwon, Park, Alan L, Scott
openaire   +2 more sources

25-Hydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell Line

Molecules, 2021
25-hydroxycholesterol (25-HC) is an oxysterol synthesized from cholesterol by cholesterol-25-hydroxylase during cholesterol metabolism. The aim of this study was to verify whether 25-HC induces oxiapoptophagy in fibroblasts.
Jae-Seek You, HyangI Lim, Jeong-Yeon Seo, Kyeong-Rok Kang, Do Kyung Kim, Ji-Su Oh, Yo-Seob Seo, Gyeong-Je Lee, Jin-Soo Kim, Heung-Joong Kim, Sun-Kyoung Yu, Jae-Sung Kim   +11 more
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