Ch25h and 25-HC prevent liver steatosis through regulation of cholesterol metabolism and inflammation [PDF]
Acta Biochimica et Biophysica Sinica, 2022 Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent metabolic disorder all over the world, and lipid metabolic disorders and inflammation are closely associated and contribute to the pathogenesis of NAFLD. Cholesterol 25-hydroxylase
Wang Yaqiong +9 more
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25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway. [PDF]
Int J Oncol, 2019 Hyperlipidemia is associated with metastasis in patients with gastric cancer (GC). 25‑Hydroxycholesterol (25‑HC) is a type of oxysterol which is synthesized from cholesterol and is involved in a number of processes, including inflammation, immune responses and cancer development. However, the role of 25‑HC in gastric cancer remains unknown.
Wang S, Yao Y, Rao C, Zheng G, Chen W.
europepmc +4 more sources
The compound LY295427 antagonizes 25-hydroxycholesterol through binding to INSIG [PDF]
Journal of Lipid Research25-Hydroxycholesterol (25-HC) regulates cholesterol metabolism by inhibiting the maturation of SREBP and promoting the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR).
Xing-Yan Wen +8 more
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Peroxisomal ABCD1 deficiency in mice drives Th1 bias through 25-HC–LXR signaling in CD4+ T cells [PDF]
Frontiers in ImmunologyX-linked adrenoleukodystrophy (X-ALD) is driven by ABCD1 dysfunction, causing very-long-chain fatty acid (VLCFA) accumulation and cerebral inflammation, yet the role of T cells in X-ALD remains unclear.
Reina Maeda +7 more
doaj +2 more sources
CH25H-mediated cholesterol metabolism drives chondrogenic differentiation in adipose-derived stem cells and enhances cartilage repair [PDF]
Communications BiologyCartilage defects are difficult to heal because articular cartilage is both avascular and aneural. Directing adipose-derived mesenchymal stem cells (ADSCs) toward a chondrogenic fate in vitro is regarded as a promising therapeutic strategy.
Yang Wang +7 more
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ImmunobiologyObjective: Chronic obstructive pulmonary disease (COPD) is intricately linked to pulmonary fibrosis, yet the underlying mechanisms remain unclear. This study investigates whether CH25H/25-hydroxycholesterol (25-HC) promotes pulmonary fibrosis in COPD by ...
Ying Li +6 more
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25-Hydroxycholesterol-Induced Oxiapoptophagy in L929 Mouse Fibroblast Cell Line
Molecules, 2021 25-hydroxycholesterol (25-HC) is an oxysterol synthesized from cholesterol by cholesterol-25-hydroxylase during cholesterol metabolism. The aim of this study was to verify whether 25-HC induces oxiapoptophagy in fibroblasts.
Jae-Seek You +11 more
doaj +1 more source
The cholesterol metabolite 25-hydroxycholesterol activates estrogen receptor α-mediated signaling in cancer cells and in cardiomyocytes. [PDF]
PLoS ONE, 2011 The hydroxylated derivatives of cholesterol, such as the oxysterols, play important roles in lipid metabolism. In particular, 25-hydroxycholesterol (25 HC) has been implicated in a variety of metabolic events including cholesterol homeostasis and ...
Rosamaria Lappano +6 more
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Hepatic Reduction in Cholesterol 25-Hydroxylase Aggravates Diet-induced SteatosisSummary
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti-inflammatory and antiviral activities.
Zeyu Dong +10 more
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Biochemistry and Biophysics Reports, 2020 The oxysterol 25-hydroxycholesterol (25-HC) has diverse physiological activities, including the ability to inhibit anchorage-independent growth of colorectal cancer cells. Here, we found that a polyamine synthesis inhibitor, DFMO, prevented 25-HC-induced
Miku Kakimoto +2 more
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