Results 21 to 30 of about 246,364 (197)

25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism[S]

open access: yesJournal of Lipid Research, 2018
Cholesterol 25-hydroxylase (CH25H) catalyzes the production of 25-hydroxycholesterol (25-HC), an oxysterol that can play an important role in different biological processes.
Ying Liu   +10 more
doaj   +1 more source

Acute and long-term immune responses to SARS-CoV-2 infection in unvaccinated children and young adults with inborn errors of immunity

open access: yesFrontiers in Immunology, 2023
PurposeTo describe SARS-CoV-2 infection outcome in unvaccinated children and young adults with inborn errors of immunity (IEI) and to compare their specific acute and long-term immune responses with a sex-, age-, and severity-matched healthy population ...
Ana García-García   +51 more
doaj   +1 more source

Mass spectrometry profiling of oxysterols in human sperm identifies 25-hydroxycholesterol as a marker of sperm function

open access: yesRedox Biology, 2017
Cholesterol is a main lipid component of sperm cell that is essential for sperm membrane fluidity, capacitation, and acrosomal reaction. Recent data obtained in bovine sperm showed that sperm capacitation is associated to the formation of oxysterols ...
Chiara Zerbinati   +12 more
doaj   +1 more source

Role of cytochrome P450 for vitamin D metabolisms in patients with neurodegenerative disorders

open access: yesClinical Parkinsonism & Related Disorders, 2022
Introduction: We previously reported lower serum 25-hydroxyvitamin D concentrations in patients with Alzheimer’s disease (AD), Parkinson’s disease (PD) and Multiple system atrophy (MSA) compared to healthy controls (HC), whereas 1,25-di-hydroxyvitamin D ...
Asako Kakimoto   +7 more
doaj   +1 more source

Increased 25-hydroxycholesterol as an indicator for patients with vestibular neuritis

open access: yesFrontiers in Neurology
BackgroundVestibular neuritis (VN) is one of the most common diseases in vestibular vertigo. 25-hydroxycholesterol (25-HC) was correlated to neuroinflammation, however, whether the level of serum 25-HC could be used to diagnose the VN occurrence remains ...
Xuhua Song, Jingwei Liang, Congzhe Tian
doaj   +1 more source

Effects of dietary β-mannanase (Hemicell®) and Lavandula angustifolia on Oreochromis niloticus fed a low level of dietary protein: Growth, digestive enzymes, and hemato-biochemical indices

open access: yesAquaculture Reports, 2023
High feed prices and limited access to feed are two critical problems faced by fish producers. One approach that farmers may consider is using less expensive and locally available components.
Ashraf Y. El-Dakar   +8 more
doaj   +1 more source

Coagulation status, fibrinolysis, and platelet dynamics in dogs with chronic inflammatory enteropathy

open access: yesJournal of Veterinary Internal Medicine, 2021
Background Coagulation status is poorly understood in dogs with chronic inflammatory enteropathy (CIE). Fibrinolytic activity and platelet dynamics have not been evaluated in CIE dogs.
Sara A. Jablonski Wennogle   +2 more
doaj   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási   +14 more
wiley   +1 more source

25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome

open access: yesNature Communications, 2016
The mechanism underlying neuroinflammation in X-linked adrenoleukodystrophy (ALD) is poorly understood. Here authors identify aberrant production of 25-hydroxycholesterol (25-HC) in ALD patient-derived cells, and show that 25-HC mediates ...
Jiho Jang   +13 more
doaj   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters   +17 more
wiley   +1 more source

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