Frontiers in Marine Science, 2020 Our previous studies have shown that ARA regulated the gonadal steroidogenesis and the synthesis of gonadotrophin-releasing hormone (GnRH) in the brain in a gender-dependent manner in Chinese tongue sole, a marine teleost with typical sex dimorphism.
Houguo Xu, Linlin Jia, Yuliang Wei
exaly +3 more sources
Pan-cancer multi-dimensional characterization and biological significance of cholesterol 25-hydroxylase (CH25H) [PDF]
Discover OncologyBackground CH25H encodes an interferon-inducible hydroxylase that converts cholesterol to 25-hydroxycholesterol (25-HC), linking lipid homeostasis to immune regulation. Its pan-cancer relevance remains incompletely defined.
Zhongqi Diao, Yi Chen, Wenjia Guo
doaj +2 more sources
Detection of CH25H gene polymorphism associated with growth traits of Yuexi frizzled chicken [PDF]
Poultry ScienceYuexi frizzled chicken has unique disease resistance and growth performance. Cholesterol 25-hydroxylase (CH25H) and its enzymatic product 25-hydroxycholesterol (25-HC) are recognized as key modulators of inflammatory signaling, immune defense, and viral ...
Yuying Li +6 more
doaj +2 more sources
Silencing of Cholesterol 25-Hydroxylase Attenuates Lipopolysaccharide-Induced Cardiomyocyte Damage In Vitro. [PDF]
J Cell Mol MedABSTRACT The underlying mechanisms of sepsis‐induced myocardial dysfunction (SIMD) remain elusive, and no targeted therapies currently exist. This study aimed to explore the expression features and functional effects of cholesterol 25‐hydroxylase (CH25H) in SIMD in vitro.
Men YJ +8 more
europepmc +2 more sources
Cholesterol 25-hydroxylase inhibits Newcastle disease virus replication by enzyme activity-dependent and direct interaction with nucleocapsid protein [PDF]
Journal of VirologyNewcastle disease virus (NDV) is a significant enveloped virus within the Paramyxoviridae family, posing a major threat to the global poultry industry.
Guangmei Zhu +15 more
doaj +2 more sources
Viruses, 2020 With the frequent outbreaks of emerging infectious diseases in recent years, an effective broad-spectrum antiviral drug is becoming an urgent need for global public health.
Jin Zhao, Minchao Li, Caijun Sun
exaly +3 more sources
Heightened cholesterol 25-hydroxylase expression in aged lung during Streptococcus pneumoniae [PDF]
Frontiers in AgingIntroductionAlveolar macrophages (AM) are critical effectors of the immune response and are essential for host responses to Streptococcus pneumoniae. Changes in lipid metabolism in AM can alter cellular function and biology.
David G. Thomas +5 more
doaj +2 more sources
ImmunobiologyObjective: Chronic obstructive pulmonary disease (COPD) is intricately linked to pulmonary fibrosis, yet the underlying mechanisms remain unclear. This study investigates whether CH25H/25-hydroxycholesterol (25-HC) promotes pulmonary fibrosis in COPD by ...
Guangzhi Xiao +2 more
exaly +3 more sources
Cholesterol 25‐Hydroxylase Enhances Myeloid‐Derived Suppressor Cell (MDSC) Immunosuppression via the Stimulator of Interferon Genes (STING)‐Tank‐Binding Kinase 1 (TBK1)‐Receptor‐Interacting Protein Kinase 3 (RIPK3) Pathway in Colorectal Cancer [PDF]
MedCommMyeloid‐derived suppressor cells (MDSCs) represent a significant immunosuppressive population within the tumor microenvironment of colorectal cancer (CRC).
Dongqin Zhou +14 more
doaj +2 more sources
Cancer MedicineBackground Laryngeal squamous cell carcinoma (LSCC) is a type of cancer of the respiratory tract that often presents with subtle symptoms at the early stage and is susceptible to recurrence and metastasis. Materials and Methods To find out key regulatory
Qun Li, Zhenhua Wu
exaly +2 more sources