Results 21 to 30 of about 2,414 (116)

25-Hydroxycholesterol modulates microglial function and exacerbates Alzheimer’s disease pathology: mechanistic insights and therapeutic potential of cholesterol esterification inhibition [PDF]

Journal of Neuroinflammation
This study investigates the role of 25-hydroxycholesterol (25HC), a metabolite produced by cholesterol hydroxylase encoded by the Ch25h gene, in modulating microglial function and its potential implications in Alzheimer’s disease (AD) pathology.
Hayoung Choi, Haeng Jun Kim, Sang-Eun Lee, Hyun Ho Song, Jieun Kim, Jihui Han, June-Hyun Jeong, Do Yup Lee, Sunghoe Chang, Inhee Mook-Jung   +9 more
doaj   +2 more sources

Hepatic Reduction in Cholesterol 25-Hydroxylase Aggravates Diet-induced SteatosisSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-hydroxycholesterol (25-HC), is critical in modulating cellular lipid metabolism and anti-inflammatory and antiviral activities.
Zeyu Dong, Fangzhou He, Xiaosong Yan, Yuanming Xing, Yuyang Lei, Jie Gao, Ming He, Dongmin Li, Liang Bai, Zuyi Yuan, John Y-J. Shyy   +10 more
doaj   +1 more source

Dual-Role of Cholesterol‐25‐Hydroxylase in Regulating Hepatitis B Virus Infection and Replication

mBio, 2022
Hepatitis B virus (HBV)‐related diseases are among the major diseases that affect millions of people worldwide. These diseases are difficult to eradicate and thus pose a serious global health challenge.
Qi Wei, Hongxiao Song, Yanli Gao, Fengchao Xu, Qingfei Xiao, Fei Wang, Bingxin Lei, Junqi Niu, Pujun Gao, Haichun Ma, Guangyun Tan   +10 more
doaj   +1 more source

Cholesterol 25-Hydroxylase Suppresses Swine Acute Diarrhea Syndrome Coronavirus Infection by Blocking Spike Protein-Mediated Membrane Fusion

Viruses, 2023
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging porcine intestinal coronavirus that can cause acute diarrhea, vomiting, rapid weight loss, and high mortality in newborn piglets.
Dakai Liu, Da Shi, Hongyan Shi, Liaoyuan Zhang, Jiyu Zhang, Miaomiao Zeng, Tingshuai Feng, Xiaoman Yang, Xin Zhang, Jianfei Chen, Zhaoyang Jing, Zhaoyang Ji, Jialin Zhang, Li Feng   +13 more
doaj   +1 more source

Novel CH25H+ and OASL+ microglia subclusters play distinct roles in cerebral ischemic stroke

Journal of Neuroinflammation, 2023
Background Microglial polarization is one of the most promising therapeutic targets for multiple central nervous system (CNS) disorders, including ischemic stroke.
Yueman Zhang, Yunlu Guo, Ruqi Li, Tingting Huang, Yan Li, Wanqin Xie, Chen Chen, Weijie Chen, Jieqing Wan, Weifeng Yu, Peiying Li   +10 more
doaj   +1 more source

Cholesterol 25-hydroxylase suppresses avian reovirus replication by its enzymatic product 25-hydroxycholesterol

Frontiers in Microbiology, 2023
Avian reovirus (ARV) causing viral arthritis/tenosynovitis and viral enteritis in domestic fowl has significantly threatened on the poultry industry worldwide. ARV is a non-enveloped fusogenic virus that belongs to the Reoviridae family.
Yuyang Wang, Yuyang Wang, Wei Zuo, Yangyang Zhang, Zongyi Bo, Zongyi Bo, Chengcheng Zhang, Xiaorong Zhang, Yantao Wu, Yantao Wu   +9 more
doaj   +1 more source

25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism[S]

Journal of Lipid Research, 2018
Cholesterol 25-hydroxylase (CH25H) catalyzes the production of 25-hydroxycholesterol (25-HC), an oxysterol that can play an important role in different biological processes.
Ying Liu, Zhuo Wei, Xingzhe Ma, Xiaoxiao Yang, Yuanli Chen, Lei Sun, Chuanrui Ma, Qing R. Miao, David P. Hajjar, Jihong Han, Yajun Duan   +10 more
doaj   +1 more source

Antiviral Actions of 25-Hydroxycholesterol in Fish Vary With the Virus-Host Combination

Frontiers in Immunology, 2021
Cholesterol is essential for building and maintaining cell membranes and is critical for several steps in the replication cycle of viruses, especially for enveloped viruses. In mammalian cells virus infections lead to the accumulation of the oxysterol 25-
Mikolaj Adamek, Jonathan Davies, Jonathan Davies, Alexander Beck, Lisa Jordan, Anna M. Becker, Miriam Mojzesz, Krzysztof Rakus, Typhaine Rumiac, Bertrand Collet, Graham Brogden, Graham Brogden, Graham Brogden, Keith Way, Sven M. Bergmann, Jun Zou, Jun Zou, Jun Zou, Jun Zou, Dieter Steinhagen   +19 more
doaj   +1 more source

Role of Cholesterol 25-Hydroxylase (Ch25h) in Mediating Innate Immune Responses to Streptococcus pneumoniae Infection

Cells, 2023
Alveolar macrophages (AM) are long-lived tissue-resident innate immune cells of the airways. AM are key effectors of recognition, initiation, and resolution of the host defense against microbes and play an essential role in mediating host responses to ...
Soo Jung Cho, Alexander Pronko, Jianjun Yang, Kassandra Pagan, Heather Stout-Delgado   +4 more
doaj   +1 more source

25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation

mBio, 2016
Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25 ...
Punya Shrivastava-Ranjan, Éric Bergeron, Ayan K. Chakrabarti, César G. Albariño, Mike Flint, Stuart T. Nichol, Christina F. Spiropoulou   +6 more
doaj   +1 more source