Results 1 to 10 of about 713 (104)

Multifaceted Functions of CH25H and 25HC to Modulate the Lipid Metabolism, Immune Responses, and Broadly Antiviral Activities [PDF]

Viruses, 2020
With the frequent outbreaks of emerging infectious diseases in recent years, an effective broad-spectrum antiviral drug is becoming an urgent need for global public health.
Jin Zhao, Minchao Li, Caijun Sun
exaly   +5 more sources

Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol

Journal of Lipid Research, 2023
Neuroinflammation, a major hallmark of Alzheimer’s disease and several other neurological and psychiatric disorders, is often associated with dysregulated cholesterol metabolism.
Anil G Cashikar, Danira Toral-Rios, Michael R Strickland   +2 more
exaly   +3 more sources

25-hydroxycholesterol: an integrator of antiviral ability and signaling [PDF]

Frontiers in Immunology, 2023
Cholesterol, as an important component in mammalian cells, is efficient for viral entry, replication, and assembly. Oxysterols especially hydroxylated cholesterols are recognized as novel regulators of the innate immune response. The antiviral ability of
Jialu Zhang, Jialu Zhang, Yaohong Zhu, Yaohong Zhu, Xiaojia Wang, Xiaojia Wang, Jiufeng Wang, Jiufeng Wang   +7 more
doaj   +2 more sources

Cholesterol 25-Hydroxylase Suppresses Swine Acute Diarrhea Syndrome Coronavirus Infection by Blocking Spike Protein-Mediated Membrane Fusion [PDF]

Viruses, 2023
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is an emerging porcine intestinal coronavirus that can cause acute diarrhea, vomiting, rapid weight loss, and high mortality in newborn piglets.
Dakai Liu, Da Shi, Hongyan Shi, Liaoyuan Zhang, Jiyu Zhang, Miaomiao Zeng, Tingshuai Feng, Xiaoman Yang, Xin Zhang, Jianfei Chen, Zhaoyang Jing, Zhaoyang Ji, Jialin Zhang, Li Feng   +13 more
doaj   +2 more sources

25-Hydroxycholesterol modulates microglial function and exacerbates Alzheimer’s disease pathology: mechanistic insights and therapeutic potential of cholesterol esterification inhibition [PDF]

Journal of Neuroinflammation
This study investigates the role of 25-hydroxycholesterol (25HC), a metabolite produced by cholesterol hydroxylase encoded by the Ch25h gene, in modulating microglial function and its potential implications in Alzheimer’s disease (AD) pathology.
Hayoung Choi, Haeng Jun Kim, Sang-Eun Lee, Hyun Ho Song, Jieun Kim, Jihui Han, June-Hyun Jeong, Do Yup Lee, Sunghoe Chang, Inhee Mook-Jung   +9 more
doaj   +2 more sources

The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation [PDF]

Veterinary Research
25-Hydroxycholesterol (25HC) is a hydroxylated cholesterol with multiple antiviral activities, however, little is known about the mechanisms by which 25HC correlates antiviral ability with lipid droplet (LD) dynamic balance to ensure cholesterol ...
Jia-lu Zhang, Xue-fei Wang, Jia-lin Li, Cong Duan, Jiu-feng Wang   +4 more
doaj   +2 more sources

25HC regulates the polarization of CD163+ macrophages in the immune microenvironment of triple-negative breast cancer through the interferon pathway [PDF]

Frontiers in Immunology
IntroductionTriple-negative breast cancer (TNBC) is a highly aggressive subtype with limited therapeutic options. Reprogramming the tumor immune microenvironment (TIME) has emerged as a promising strategy for breast cancer treatment, and tumor-associated
Hongmei Zheng, Wenqin Huang, Panshi Zhang, Sudhanshu Bhushan, Xinhong Wu, Yalong Yang   +5 more
doaj   +2 more sources

Effects of acute pro-inflammatory stimulation and 25-hydroxycholesterol on hippocampal plasticity and learning involve NLRP3 inflammasome and cellular stress responses [PDF]

Scientific Reports
Neuroinflammation is an increasingly important target for therapeutics in neuropsychiatry and contributes to cognitive dysfunction, disability and death across a range of illnesses.
Yukitoshi Izumi, Kazuko A. O’Dell, Steven Mennerick, Charles F. Zorumski   +3 more
doaj   +2 more sources

Cholesterol 25‐Hydroxylase Enhances Myeloid‐Derived Suppressor Cell (MDSC) Immunosuppression via the Stimulator of Interferon Genes (STING)‐Tank‐Binding Kinase 1 (TBK1)‐Receptor‐Interacting Protein Kinase 3 (RIPK3) Pathway in Colorectal Cancer [PDF]

MedComm
Myeloid‐derived suppressor cells (MDSCs) represent a significant immunosuppressive population within the tumor microenvironment of colorectal cancer (CRC).
Dongqin Zhou, Yu Chen, Xudong Liu, Juan He, Luyao Shen, Yongpeng He, Jiangang Zhang, Yu Zhou, Nan Zhang, Yanquan Xu, Juan Lei, Ran Ren, Huakan Zhao, Xianghua Zeng, Yongsheng Li   +14 more
doaj   +2 more sources

Ch25h/25HC axis orchestrates phagocytosis and lipid metabolism after intracerebral haemorrhage

Abstract Intracerebral haemorrhage (ICH) is a devastating form of stroke for which therapies are lacking. Secondary brain injury driven by erythrocyte lysis contributes to poor outcomes, highlighting the need to enhance endogenous haematoma clearance.
Lawrence CB, Zhou R, Tapia V, Bennington A, Gao R, Elmes M, Lin I, Dai Z, Crilly S, Pot C, Allan S, Kasher P.   +11 more
europepmc   +2 more sources