Results 21 to 30 of about 732 (118)

Late Life Supplementation of 25-Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice. [PDF]

Aging Cell
25‐hydroxycholesterol (25HC) targets senescent cell anti‐apoptotic pathways (SCAPs) to reduce vascular cell senescence, favorably remodel aortic wall components, and reduce aortic stiffening with advancing age. ABSTRACT Stiffening of the aorta is a key antecedent to cardiovascular diseases (CVD) with aging.
Mahoney SA, Darrah MA, Venkatasubramanian R, Ciotlos S, Rossman MJ, Campisi J, Seals DR, Melov S, Clayton ZS.   +8 more
europepmc   +2 more sources

25-Hydroxycholesterol Inhibits Kaposi’s Sarcoma Herpesvirus and Epstein-Barr Virus Infections and Activates Inflammatory Cytokine Responses

mBio, 2021
Oncogenic gammaherpesviruses express viral products during latent and lytic infection that block the innate immune response. Previously, we found that Kaposi’s sarcoma herpesvirus (KSHV/human herpesvirus-8) viral microRNAs (miRNAs) downregulate ...
Anna K. P. Serquiña, Takanobu Tagawa, Daniel Oh, Guruswamy Mahesh, Joseph M. Ziegelbauer   +4 more
doaj   +1 more source

Targeting CH25H/25HC-ferroptosis axis: a novel mechanism of MSC-EVs mediated renoprotection in ischemic AKI

Journal of Nanobiotechnology
Qin Yang, Yi-Lin Zhang, Si-Jie Chen, Jing Song, Qing Yin, Yi Wen, Hong-Bin Yang, Qiu-Li Wu, Yue Zhang, Yu-Qi Fu, Bin Wang, Min Yang, Suo-Fu Qin, Lin-Li Lv, Tao-Tao Tang, Bi-Cheng Liu   +15 more
exaly   +2 more sources

25-Hydroxycholesterol Mediates Cholesterol Metabolism to Restrict Porcine Deltacoronavirus Infection via Suppression of Transforming Growth Factor β1

Microbiology Spectrum, 2022
Porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus in pigs, is one of the major pathogens for lethal watery diarrhea in piglets and poses a threat to public health because of its potential for interspecies transmission to humans ...
Jialu Zhang, Guanghui Yang, Xuefei Wang, Yaohong Zhu, Jiufeng Wang   +4 more
doaj   +1 more source

A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

eLife, 2023
Most of the cholesterol in the plasma membranes (PMs) of animal cells is sequestered through interactions with phospholipids and transmembrane domains of proteins.
David B Heisler, Kristen A Johnson, Duo H Ma, Maikke B Ohlson, Lishu Zhang, Michelle Tran, Chase D Corley, Michael E Abrams, Jeffrey G McDonald, John W Schoggins, Neal M Alto, Arun Radhakrishnan   +11 more
doaj   +1 more source

Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3

Scientific Reports, 2023
A growing body of evidence suggests that oxysterols such as 25-hydroxycholesterol (25HC) are biologically active and involved in many physiological and pathological processes.
Jeevan B. Gc, Justin Chen, Swechha M. Pokharel, Indira Mohanty, Charles Mariasoosai, Peter Obi, Paul Panipinto, Smarajit Bandyopadhyay, Santanu Bose, Senthil Natesan   +9 more
doaj   +1 more source

Tumor Necrosis Factor-alpha utilizes MAPK/NFκB pathways to induce cholesterol-25 hydroxylase for amplifying pro-inflammatory response via 25-hydroxycholesterol-integrin-FAK pathway.

PLoS ONE, 2021
Exaggerated inflammatory response results in pathogenesis of various inflammatory diseases. Tumor Necrosis Factor-alpha (TNF) is a multi-functional pro-inflammatory cytokine regulating a wide spectrum of physiological, biological, and cellular processes.
Swechha M Pokharel, Kim Chiok, Niraj K Shil, Indira Mohanty, Santanu Bose   +4 more
doaj   +1 more source

Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types

iScience, 2022
Summary: Cellular senescence is a driver of many age-related pathologies. There is an active search for pharmaceuticals termed senolytics that can mitigate or remove senescent cells in vivo by targeting genes that promote the survival of senescent cells.
Chandani Limbad, Ryosuke Doi, Julia McGirr, Serban Ciotlos, Kevin Perez, Zachary S. Clayton, Radha Daya, Douglas R. Seals, Judith Campisi, Simon Melov   +9 more
doaj   +1 more source

25-Hydroxycholesterol exacerbates vascular leak during acute lung injury

JCI Insight, 2023
Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung biology is poorly defined.
Jennifer H. Madenspacher, Eric D. Morrell, Jeffrey G. McDonald, Bonne M. Thompson, Yue Li, Konstantin G. Birukov, Anna A. Birukova, Renee D. Stapleton, Aidin Alejo, Peer W. Karmaus, Julie M. Meacham, Prashant Rai, Carmen Mikacenic, Mark M. Wurfel, Michael B. Fessler   +14 more
doaj   +1 more source

Design and Characterization of Model Systems that Promote and Disrupt Transparency of Vertebrate Crystallins In Vitro

Advanced Science, Volume 10, Issue 35, December 15, 2023., 2023
Human vision is enabled through the transmission, refraction, and color‐sensing of light through the eye. Combining analytical and computational methods, the properties and interactions of lens crystallins that enable their organized, dense‐packing into a transparent microstructure are explored.
Michael R. Bergman, Sophia A. Hernandez, Caitlin Deffler, Jingjie Yeo, Leila F. Deravi   +4 more
wiley   +1 more source