Results 41 to 50 of about 732 (118)

25-Hydroxycholesterol and 27-hydroxycholesterol inhibit human rotavirus infection by sequestering viral particles into late endosomes

Redox Biology, 2018
A novel innate immune strategy, involving specific cholesterol oxidation products as effectors, has begun to reveal connections between cholesterol metabolism and immune response against viral infections.
Andrea Civra, Rachele Francese, Paola Gamba, Gabriella Testa, Valeria Cagno, Giuseppe Poli, David Lembo   +6 more
doaj   +1 more source

High Glucose Induces Lipid Accumulation via 25-Hydroxycholesterol DNA-CpG Methylation

iScience, 2020
Summary: This work investigates the relationship between high-glucose (HG) culture, CpG methylation of genes involved in cell signaling pathways, and the regulation of carbohydrate and lipid metabolism in hepatocytes.
Yaping Wang, Lanming Chen, William M. Pandak, Douglas Heuman, Phillip B. Hylemon, Shunlin Ren   +5 more
doaj   +1 more source

Ch25h and 25-HC prevent liver steatosis through regulation of cholesterol metabolism and inflammation

Acta Biochimica et Biophysica Sinica, 2022
Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent metabolic disorder all over the world, and lipid metabolic disorders and inflammation are closely associated and contribute to the pathogenesis of NAFLD. Cholesterol 25-hydroxylase
Wang Yaqiong, Zhang Jin, Chen Jie, Wang Dan, Yu Yang, Qiu Pei, Wang Qiqi, Zhao Wenbao, Li Zhao, Lei Ting   +9 more
doaj   +1 more source

Natural Killer Cell‐Mediated Antitumor Immunity: Molecular Mechanisms and Clinical Applications

MedComm, Volume 6, Issue 9, September 2025.
NK cells eliminate tumors via cytotoxicity and cytokine secretion. Tumor microenvironment‐driven immunosuppression and metabolic reprogramming subvert NK cells’ cytotoxicity. The current clinical strategies to restore NK activity include ex vivo expansion for adoptive transfer, CAR‐NK engineering, TME‐remodeling agents, immune checkpoint blockade ...
Nanzhi Luo, Cong Chen, Wenjing Zhou, Jianqi Hao, Song He, Yu Liu, Yin Ku, Linhua Huang, Chuanfen Zhang, Yueli Shu, Xiaoqing Wu, Yaojia Zhou, Jian Zhang   +12 more
wiley   +1 more source

Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons

Small Science, Volume 5, Issue 9, September 2025.
This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong, Yanyi Peng, Lingyue Zhang, Bo Xiao, Mengqi Zhang   +4 more
wiley   +1 more source

Genetic and Functional Characterization of Novel Brown-Like Adipocytes Around the Lamprey Brain

Frontiers in Cell and Developmental Biology, 2021
During the process of vertebrate evolution, many thermogenic organs and mechanisms have appeared. Mammalian brown adipose tissue (BAT) generates heat through the uncoupling oxidative phosphorylation of mitochondria, acts as a natural defense against ...
XiaoLuan Xu, XiaoLuan Xu, AnQi Ma, AnQi Ma, TieSong Li, TieSong Li, WenXue Cui, WenXue Cui, XueFeng Wang, XueFeng Wang, Jun Li, Jun Li, Qingwei Li, Qingwei Li, Yue Pang, Yue Pang   +15 more
doaj   +1 more source

A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat

Epilepsia, Volume 66, Issue 5, Page 1394-1405, May 2025.
Abstract Soticlestat (TAK‐935) is a potent and selective inhibitor of cholesterol 24‐hydroxylase (CYP46A1), an enzyme primarily expressed in the brain that catabolizes cholesterol to 24S‐hydroxycholesterol (24HC). In the ELEKTRA phase II clinical trial, soticlestat reduced seizure frequency in patients with developmental and epileptic encephalopathies,
Shinichi Kondo, Venkatesha Murthy, Mahnaz Asgharnejad, Arturo Benitez, Kosuke Nakashima, Nicole Hawkins, H. Steve White   +6 more
wiley   +1 more source

The Role of Cholesterol Metabolism and Its Regulation in Tumor Development

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu. Furthermore, cholesterol reprogramming within this microenvironment influences the immune landscape of tumors, facilitating immune evasion and consequently ...
Yongmei Wu, Wenqian Song, Min Su, Jing He, Rong Hu, Youbo Zhao   +5 more
wiley   +1 more source

Viral MicroRNAs Repress the Cholesterol Pathway, and 25-Hydroxycholesterol Inhibits Infection

mBio, 2017
From various screens, we found that Kaposi’s sarcoma-associated herpesvirus (KSHV) viral microRNAs (miRNAs) target several enzymes in the mevalonate/cholesterol pathway.
Anna K. P. Serquiña, Diane M. Kambach, Ontara Sarker, Joseph M. Ziegelbauer   +3 more
doaj   +1 more source

Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT

Journal of Lipid Research, 2020
The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of sterols in 206
Daisuke Yamamuro, Hisataka Yamazaki, Jun-ichi Osuga, Kenta Okada, Tetsuji Wakabayashi, Akihito Takei, Shoko Takei, Manabu Takahashi, Shuichi Nagashima, Adriaan G. Holleboom, Masayuki Kuroda, Hideaki Bujo, Shun Ishibashi   +12 more
doaj   +1 more source